DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1B and htr1a

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_004910432.2	Gene:	htr1a / 100488829	XenbaseID:	XB-GENE-984750	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	542	Identity:	173/542 - (31%)
Similarity:	236/542 - (43%)	Gaps:	172/542 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVA 140
            |.|..|:.:     .|..::.||.:||..|.||..|||||.|||.||.|||||:.||||.||.|:
Frog    21 EPEEVALSY-----QIVTSLFLGTLILCAIFGNACVIAAIALERCLQTVANYLIGSLAVTDLMVS 80

  Fly   141 CLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPR 204
            .||:|:.|..::.|.|.||...|||:.|.||||||:|||||.|||.||||.:|: |||.|.||||
Frog    81 VLVLPMAAHNQVLNKWTLGQVTCDIFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPR 145

  Fly   205 RVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFL 269
            |..::|...|.....:|:.|..||:.|:  .|.:...|.:|:|.||.|::|...||:||:::|.|
Frog   146 RAAVLISITWIVGFSISIPPMLGWRTPE--DRSDPNACKISEDPGYTIYSTFGAFYIPLILMLVL 208

  Fly   270 YWKIYIIARKRIQRRAQKSFNVTLTETDCDS---AVRELKKERSKRRAERKRLEAGERTPVDGDG 331
            |.||:..||.||::..:|:....:.:| |.|   ||.|.|......:..::.:|......|:|
Frog   209 YGKIFKAARFRIRKTVKKAEKKKVADT-CLSVSPAVAERKSNGEPSKNWKRTVEPKPSACVNG-- 270

  Fly   332 TGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNK 396
                                    .:..|.:|||.
Frog   271 ------------------------AIRHGEDGAVL------------------------------ 281

  Fly   397 SHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLI--ASHLN--------AITPLAQSI 451
                                   |||.:         ||.:  .|||:        |:.|
Frog   282 -----------------------EIIEV---------HHYVNSKSHLDLPNHAHDMAVAP----- 309

  Fly   452 AMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQK 516
                  |      |||                                           .|....
Frog   310 ------C------SEK-------------------------------------------RNDRAT 319

  Fly   517 LAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNS 581
            .|||:..|  .||||..:||.||.|.|:.||||||::||.:..|:.|.:...:..:..||||.||
Frog   320 DAKRKVAL--ARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCETCHMPHLLFDVINWLGYSNS 382

  Fly   582 TLNPVIYTIFNPEFRRAFKRIL 603
            .|||:||..||.:|:.|||:|:
Frog   383 LLNPIIYAYFNKDFQSAFKKII 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	92/181 (51%)
htr1a	XP_004910432.2	7tmA_5-HT1A_vertebrates	31..400	CDD:320453	166/521 (32%)
		TM helix 1	33..57	CDD:320453	12/23 (52%)
		TM helix 2	66..88	CDD:320453	13/21 (62%)
		TM helix 3	104..126	CDD:320453	16/21 (76%)
		TM helix 4	149..165	CDD:320453	3/15 (20%)
		TM helix 5	187..210	CDD:320453	10/22 (45%)
		TM helix 6	334..356	CDD:320453	12/21 (57%)
		TM helix 7	368..393	CDD:320453	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2699
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.090