Protein Alignment 5-HT1B and taar1

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_002935857.1
• Gene: taar1 / 100487786
• XenbaseID: XB-GENE-961114
• Length: 339
• Species: Xenopus tropicalis
• Alignment Length: 566
• Identity: 125/566 - (22%)
• Similarity: 171/566 - (30%)
• Gaps: 268/566 - (47%)

  Fly    58 NRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQ 122
            |||...||.||..                   .|.|.|.:...||.|::||:.||.:|...:.|.
 Frog    11 NRSCEKNGWSNNI-------------------RIPMYVFMVSTILATVVGNLAVIISIAHFKQLH 56

  Fly   123 NVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAAD 187
            ...|||:.|::..|..:...|||...|..:.|.|..|...|.:.||.|::..|:||.||..|:.|
 Frog    57 TPTNYLILSMSTVDFLLGSCVMPYSMVRSVENCWYFGDLFCKVHTSTDIMLSTSSIFHLSFISVD 121

  Fly   188 RYWTVTNIDYNNLRTPRRVF---LMIFCVW-----FAALIVSLAPQFGWKDPDYMKRIEEQHC-- 242
            ||:.|  .|....:|...||   |||...|     ||..:|.|.......:..|..::.   |
 Frog   122 RYFAV--CDPLRYKTKMNVFSVSLMIVTSWVVPTIFAFTMVFLELNIKGTESYYYNQVS---CFG 181

  Fly   243 ----MVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVR 303
                ..||..|  :.|:..:||:|..|:|.:|.|||:|||::
 Frog   182 GCAVFFSQTSG--LVASMVSFYIPGFVMLCVYGKIYVIARRQ----------------------- 221

  Fly   304 ELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARS 368
                                                                          |||
 Frog   222 --------------------------------------------------------------ARS 224

  Fly   369 MAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEI---ITLSQQVAH 430
            :                                             ..:||::   |||
 Frog   225 I---------------------------------------------KDSANQMPFQITL------ 238

  Fly   431 ATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTE 495
                                                                             
 Frog   239 ----------------------------------------------------------------- 238

  Fly   496 GKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLC 560
                     ||     |.|         :...|:||||:||.||.|.|:|||.|||....|....
 Frog   239 ---------GV-----NQH---------VSRSRDRKAAKTLGIIMGVFLICWTPFFFCTATDGFI 280

  Fly   561 KECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGR 606
            ... |...|...|:|:||.|||.||::|..|...|:||.:.||||:
 Frog   281 NYV-IPPIVIDAFVWIGYLNSTFNPMVYAFFYLWFQRALRMILFGK 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	9/25 (36%)
		TM helix 3	163..193	CDD:320454	13/29 (45%)
		TM helix 4	204..226	CDD:320454	10/29 (34%)
		TM helix 5	247..276	CDD:320454	11/28 (39%)
		7tm_GPCRs	<525..599	CDD:475119	33/73 (45%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	11/24 (46%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	68/209 (33%)
taar1	XP_002935857.1	7tmA_TAAR1	25..318	CDD:320438	113/524 (22%)
		TM helix 1	26..52	CDD:320438	10/25 (40%)
		TM helix 2	59..85	CDD:320438	9/25 (36%)
		TM helix 3	97..127	CDD:320438	14/31 (45%)
		TM helix 4	139..162	CDD:320438	8/22 (36%)
		TM helix 5	188..217	CDD:320438	13/30 (43%)
		TM helix 6	247..277	CDD:320438	17/29 (59%)
		TM helix 7	286..311	CDD:320438	11/24 (46%)