DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1B and htr5a

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_002932543.2	Gene:	htr5a / 100487444	XenbaseID:	XB-GENE-981825	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	149/562 - (26%)
Similarity:	218/562 - (38%)	Gaps:	225/562 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SQIVWNRSINGNGNSNTFDLVDDEQERAAVEFW----LLVKMIAMAVVLGLMILVTIIGNVFVIA 113
            |::.||.:::.||:             |..:.|    ..|..:.:..:|.::::.|.:.||.|:.
Frog     7 SRMEWNITVSANGS-------------AGADSWGKHRFSVFSVLILTLLAMLVIATFLWNVLVLV 58

  Fly   114 AIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISN-GWILGPELCDIWTSCDVLCCTAS 177
            .|:..|....|.:.||||:|::|:.||.|||||..|:|::: .|.||..||.||.|.||||||||
Frog    59 TILRVRTFHRVPHNLVASMAISDVMVAALVMPLSLVHELNDRRWRLGRVLCHIWISFDVLCCTAS 123

  Fly   178 ILHLVAIAADRYWTVT-NIDYNNLRTPRRVF-LMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQ 240
            |.::.|||.||||::| :::| .|:|.:|:. :||...|..:.::||:|.|||.: .|.:..||
Frog   124 IWNVTAIALDRYWSITRHLEY-TLKTRKRISNIMILLTWLLSAVISLSPLFGWGE-TYSEVNEE- 185

  Fly   241 HCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVREL 305
             |.|||:..|.||:|...||:||.|:||:|||||..|:.||.
Frog   186 -CQVSQEPSYTIFSTFGAFYLPLCVVLFVYWKIYKAAKFRIG----------------------- 226

  Fly   306 KKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMA 370
                                                       .:.|||          :.....
Frog   227 -------------------------------------------SKKTNT----------ITPMPE 238

  Fly   371 AIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHH 435
            .|.|..||   .:.:..|:.      .||   ..|..:|.|.:|
Frog   239 VIEVKEAS---HQPQMVFTV------RHA---TVTFQTDGDTWR--------------------- 270

  Fly   436 LIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAG 500

Frog   271 ----------------------------------------------------------------- 270

  Fly   501 VGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEI 565
                                     .::|:|||..:.|:.|.||:||:|||:..|...|| .|:|
Frog   271 -------------------------EQKEKKAALMVGILIGVFVLCWIPFFITELINPLC-SCDI 309

  Fly   566 HTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRK 607
            .....|:||||||.||..||:|||.||..:..|| |.||.|:
Frog   310 PPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF-RNLFSRQ 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	85/183 (46%)
htr5a	XP_002932543.2	7tmA_5-HT5	36..343	CDD:320451	135/510 (26%)
		TM helix 1	37..63	CDD:320451	6/25 (24%)
		TM helix 2	70..96	CDD:320451	14/25 (56%)
		TM helix 3	109..139	CDD:320451	20/29 (69%)
		TM helix 4	151..172	CDD:320451	6/20 (30%)
		TM helix 5	191..220	CDD:320451	16/28 (57%)
		TM helix 6	272..302	CDD:320451	14/29 (48%)
		TM helix 7	311..336	CDD:320451	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5850
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010