DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and adra2b

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:XP_002932610.1 Gene:adra2b / 100485811 XenbaseID:XB-GENE-999343 Length:410 Species:Xenopus tropicalis


Alignment Length:521 Identity:145/521 - (27%)
Similarity:234/521 - (44%) Gaps:144/521 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 MAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWI 157
            :|.::..::|.||.|||.||.|::..|:|:...|..:.|||.||:.||.|::|.....|:...|.
 Frog    15 IAAIITFLVLFTIFGNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPFSLANELMGYWY 79

  Fly   158 LGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVS 221
            .|...|:::.:.|||.||:||:||.||:.||||:|:. |:||:.|||:|:..:|..||..|.::|
 Frog    80 FGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCIILIVWTLAALIS 144

  Fly   222 LAPQFGWKDPDYMKRIEEQH----CMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ 282
            |.|..      |..:.::|:    |.::::..|.:.::.|:|:.|.|:::.:|.:||:||::|.:
 Frog   145 LPPLI------YKGKSKDQNAKPECKLNEEPWYILSSSICSFFAPCLIMILVYLRIYLIAKRRNR 203

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC 347
            :.:          ||     ::|||           :..|             |..||.|.    
 Frog   204 KNS----------TD-----KKLKK-----------MAPG-------------LFSRTNKH---- 225

  Fly   348 FGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADD 412
                                          ||               |.||..|:...:||..  
 Frog   226 ------------------------------SL---------------NSSHTQTQCGIISSQE-- 243

  Fly   413 YRTSNANEIITLSQQVAHATQH----HLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAG 473
             :|..|.:.:.....|..:|:.    |   |....:.|..:::.... ||      ....:....
 Frog   244 -KTGLALDDLHCGVPVLSSTREERNGH---SESFGLQPQGENLKHTN-GC------EPAVMDTVA 297

  Fly   474 TVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAI 538
            ||.|.:....|:...:                 |:|        ||::..:  .||::....||:
 Frog   298 TVKGVMLMPKGAKDSD-----------------LSS--------AKKKSYI--NREKRFTFVLAV 335

  Fly   539 ITGAFVICWLPFFVMALTMSLCKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRI 602
            :.|.||:||.|||......::|.| |.|..:|...|.|:||.||:||||||||||.:||:||:||
 Frog   336 VIGVFVLCWFPFFFTYSLGAICTELCYIPDSVFQFFFWIGYCNSSLNPVIYTIFNQDFRKAFRRI 400

  Fly   603 L 603
            |
 Frog   401 L 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/24 (42%)
TM helix 2 125..151 CDD:320454 10/25 (40%)
TM helix 3 163..193 CDD:320454 16/29 (55%)
TM helix 4 204..226 CDD:320454 8/21 (38%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 35/74 (47%)
TM helix 6 533..555 CDD:410628 10/21 (48%)
TM helix 7 567..592 CDD:410628 15/24 (63%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 70/198 (35%)
adra2bXP_002932610.1 7tmA_alpha2B_AR 7..397 CDD:320444 140/515 (27%)
TM helix 1 14..40 CDD:320444 10/24 (42%)
TM helix 2 47..73 CDD:320444 10/25 (40%)
TM helix 3 85..115 CDD:320444 16/29 (55%)
TM helix 4 127..150 CDD:320444 8/28 (29%)
TM helix 5 168..197 CDD:320444 8/28 (29%)
TM helix 6 324..354 CDD:320444 12/29 (41%)
TM helix 7 365..390 CDD:320444 15/24 (63%)

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