Protein Alignment 5-HT1B and drd1

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017947694.2
• Gene: drd1 / 100485463
• XenbaseID: XB-GENE-6035431
• Length: 451
• Species: Xenopus tropicalis
• Alignment Length: 532
• Identity: 127/532 - (23%)
• Similarity: 186/532 - (34%)
• Gaps: 237/532 - (44%)

  Fly    97 LGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFVACLVMPLGAVYEISNGWILGP 160
            |.::||.|::||..|.||:|..|:|:: |.|:.|.||||:||.||.||||..||.||:..|..|
 Frog    29 LSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG- 92

  Fly   161 ELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAP 224
            ..|:||.:.|::|.|||||:|..|:.||||.::: ..|....||:..|:||...|..::::|..|
 Frog    93 TFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSILISFIP 157

  Fly   225 -QFGW---KDPDYMKRIEEQH------CMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARK 279
             |..|   |...:.......|      |..|.:..|.|.::..:||:|:.:::..|.:||.||.|
 Frog   158 VQLNWHKAKTTSFFDLNITLHGRTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAAK 222

  Fly   280 RIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDG----DGTGGQLQRRT 340
            :|                                   :|:.|.||..|..    :.||
 Frog   223 QI-----------------------------------RRISALERAAVHAKNCQNSTG------- 245

  Fly   341 RKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTT 405
                      |.|                        ||...:.|:...||
 Frog   246 ----------NRN------------------------SLDCQQPESSLKTS-------------- 262

  Fly   406 VSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALS 470
                                                                             
 Frog   263 ----------------------------------------------------------------- 262

  Fly   471 GAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQT 535
                                                                   .|||.|..:|
 Frog   263 -------------------------------------------------------FKRETKVLKT 272

  Fly   536 LAIITGAFVICWLPFFVM---------ALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIF 591
            |::|.|.||.||||||::         :||.|..:...|.:....:|:|.|:.||:|||:||. |
 Frog   273 LSVIMGVFVCCWLPFFILNCIVPFCDPSLTTSGTEPFCISSTTFDVFVWFGWANSSLNPIIYA-F 336

  Fly   592 NPEFRRAFKRIL 603
            |.:||:||..:|
 Frog   337 NADFRKAFSNLL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/20 (50%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	6/22 (27%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	34/82 (41%)
		TM helix 6	533..555	CDD:410628	12/30 (40%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	76/201 (38%)
drd1	XP_017947694.2	7tmA_D1A_dopamine_R	22..344	CDD:320443	124/526 (24%)
		TM helix 1	24..50	CDD:320443	10/20 (50%)
		TM helix 2	58..85	CDD:320443	16/26 (62%)
		TM helix 3	95..125	CDD:320443	16/29 (55%)
		TM helix 4	137..160	CDD:320443	6/22 (27%)
		TM helix 5	190..220	CDD:320443	8/29 (28%)
		TM helix 6	264..294	CDD:320443	16/29 (55%)
		TM helix 7	313..338	CDD:320443	11/25 (44%)