DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1B and or92a1

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_009293550.2	Gene:	or92a1 / 100147882	ZFINID:	ZDB-GENE-070806-47	Length:	358	Species:	Danio rerio

Alignment Length:	243	Identity:	49/243 - (20%)
Similarity:	93/243 - (38%)	Gaps:	67/243 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 AMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGW 156
            |:||:..|.....   |..:|:.:..:|.......|::....:.:..|..||..:  :|.::
Zfish    67 AVAVLTSLFFFSV---NCVMISVLKSKRMFYETPRYILFGHMLMNDSVLLLVTTV--MYTLA--- 123

  Fly   157 ILGPELCDI---WTSCDVLC----CT--ASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIF 211
                 ||.:   .:.|.:|.    ||  .:.|.|..::.:||..:. .:.:..:.||:|..:.|.
Zfish   124 -----LCFLPIHKSICTLLVLISYCTFFNAPLTLALMSLERYVAICFPLRHCTIATPKRTGIAIG 183

  Fly   212 CVWFAA-------LIVSLAPQFGWKDPDYMKRIEEQHC----------MVSQDVGYQIFATCCTF 259
            .:||.:       :|::|.     .:|.|:..|  ..|          .:.:..|:.:.     :
Zfish   184 IIWFLSSVNVVIDIIIALI-----NNPSYLAEI--AFCTLEKLFIAKWQIDKSQGFDVL-----Y 236

  Fly   260 YVPLLV-ILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELK 306
            :|.:.| |:|.|..|.|.||.              ...|.:||.:.||
Zfish   237 FVSVAVTIIFTYIMIMITARS--------------VSADKESAKKALK 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	40/208 (19%)
or92a1	XP_009293550.2	7tm_classA_rhodopsin-like	68..332	CDD:320086	48/242 (20%)
		TM helix 1	68..89	CDD:320086	5/23 (22%)
		TM helix 2	98..122	CDD:320086	5/25 (20%)
		TM helix 3	134..164	CDD:320086	8/29 (28%)
		TM helix 4	177..196	CDD:320086	4/18 (22%)
		TM helix 5	221..250	CDD:320086	6/33 (18%)
		TM helix 6	263..296	CDD:320086	4/8 (50%)
		TM helix 7	307..332	CDD:320086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100