Protein Alignment 5-HT1B and adra2c

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001120375.1
• Gene: adra2c / 100145449
• XenbaseID: XB-GENE-5773399
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 144/519 - (27%)
• Similarity: 221/519 - (42%)
• Gaps: 128/519 - (24%)

  Fly    93 MAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWI 157
            :|.::|.:|:.||:|||||:.|::..|.|:...|..:.|||.||:.||.||||.....|:...|.
 Frog    34 LAAIVGFLIIFTIVGNVFVVIAVLTSRALKAPQNLFLVSLASADILVAALVMPFSLANELMGYWY 98

  Fly   158 LGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVS 221
            .|...|||:.:.|||.||:||:||.||:.||||:||. ::||..|||||:..:|..||..:.::|
 Frog    99 FGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGIIVTVWLISAVIS 163

  Fly   222 LAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCC-TFYVPLLVILFLYWKIYIIARKRIQRRA 285
            ..|... .|.|....:..| |.::.|..| |.::|. :|:.|.::::.:|.:||.:|:.|.:..:
 Frog   164 FPPLIS-MDRDTEDDVYPQ-CKLNDDTWY-ILSSCIGSFFAPCIIMILVYIRIYQVAKLRTRTLS 225

  Fly   286 QKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGR 350
            :|                  |..|............|....:.||...|.
 Frog   226 EK------------------KPTRDGSSHTENGFSKGTTVKMPGDKENGH--------------- 257

  Fly   351 NTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRT 415
                         ...|.....|.|...|.:  ||:..|.|.  .:..:..|..|.||  .:.:.
 Frog   258 -------------CPPRPSPPKATDVEDLEL--EESSMSESK--RRKSSSKEDNTDSS--KERKC 303

  Fly   416 SNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVA 480
            |..|.....|.:::..                                 |.|::.
 Frog   304 SKGNSFSKQSSRLSRT---------------------------------SNKSME---------- 325

  Fly   481 GGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVI 545
                                     :.:|.....:....||:|.:| ||::....||::.|.||:
 Frog   326 -------------------------LFSSRKKKKRSSVSRRKLSQA-REKRFTFVLAVVMGVFVV 364

  Fly   546 CWLPFFVMALTMSLCKE-CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL-FGRK 607
            ||.|||.......:|:| ||:...:...|.|:||.||:||||||||||.:|||:||:|: .||:
 Frog   365 CWFPFFFSYSLYGICREACEVPETLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKKIICIGRR 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	11/24 (46%)
		TM helix 2	125..151	CDD:320454	12/25 (48%)
		TM helix 3	163..193	CDD:320454	18/29 (62%)
		TM helix 4	204..226	CDD:320454	7/21 (33%)
		TM helix 5	247..276	CDD:320454	9/29 (31%)
		7tm_GPCRs	<525..599	CDD:475119	36/74 (49%)
		TM helix 6	533..555	CDD:410628	10/21 (48%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	75/195 (38%)
adra2c	NP_001120375.1	7tmA_alpha2C_AR	32..419	CDD:320446	139/508 (27%)
		TM helix 1	33..59	CDD:320446	11/24 (46%)
		TM helix 2	66..92	CDD:320446	12/25 (48%)
		TM helix 3	104..134	CDD:320446	18/29 (62%)
		TM helix 4	146..169	CDD:320446	7/22 (32%)
		TM helix 5	187..216	CDD:320446	9/29 (31%)
		TM helix 6	346..376	CDD:320446	13/30 (43%)
		TM helix 7	387..412	CDD:320446	14/24 (58%)