Protein Alignment 5-HT1B and drd1c

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_004915948.1
• Gene: drd1c / 100124855
• XenbaseID: XB-GENE-5919679
• Length: 465
• Species: Xenopus tropicalis
• Alignment Length: 530
• Identity: 121/530 - (22%)
• Similarity: 186/530 - (35%)
• Gaps: 241/530 - (45%)

  Fly    95 VVLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFVACLVMPLGAVYEISNGWIL 158
            ::|.|:||.|::||..|..|:|..|:|:: |.|:.|.||||:|||||.||||..||.|::..|:.
 Frog    33 LLLSLLILSTLLGNTLVCLAVIKFRHLRSKVTNFFVISLAVSDLFVALLVMPWKAVTEVAGYWLF 97

  Fly   159 GPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSL 222
            | :.||.|.:.|::|.|||||:|..|:.||||.:.: ..|....|.|..|:||...|..::::|.
 Frog    98 G-DFCDTWVAFDIMCSTASILNLCIISLDRYWAIASPFRYERKMTQRVAFIMIGVAWTLSILISF 161

  Fly   223 AP-QFGWKDPDYMKRIEE--------QHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIAR 278
            .| |..|..   .:.::|        ::|..|.:..|.|.::..:||:|:::::..|.:||.||:
 Frog   162 IPVQLSWHK---SQEVDEELNAINHTENCDSSLNRTYAISSSLISFYIPVVIMIGTYTRIYRIAQ 223

  Fly   279 KRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKR 343
            .:|:|
 Frog   224 TQIRR------------------------------------------------------------ 228

  Fly   344 MRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSS 408
                                                                             
 Frog   229 ----------------------------------------------------------------- 228

  Fly   409 DADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAG 473
                        |.:|.:.|.||...|...|:.|::.
 Frog   229 ------------ISSLERAVEHAQSGHPDCSNENSLK---------------------------- 253

  Fly   474 TVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAI 538
                                                              ...::|.|..:||:|
 Frog   254 --------------------------------------------------TSFRKETKVLKTLSI 268

  Fly   539 ITGAFVICWLPFFVMALTMSLC-------KECE---IHTAVASLFLWLGYFNSTLNPVIYTIFNP 593
            |.|.||.|||||||:...:..|       .|.|   :.....::|:|.|:.||:||||||. ||.
 Frog   269 IMGVFVFCWLPFFVLNCMIPFCHMSLPGQNEPEPPCVSETTFNIFVWFGWANSSLNPVIYA-FNA 332

  Fly   594 EFRRAFKRIL 603
            :||:||..||
 Frog   333 DFRKAFTTIL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/22 (45%)
		TM helix 2	125..151	CDD:320454	17/25 (68%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	7/22 (32%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	34/83 (41%)
		TM helix 6	533..555	CDD:410628	14/21 (67%)
		TM helix 7	567..592	CDD:410628	11/24 (46%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	75/202 (37%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	111/511 (22%)
		TM helix 2	64..91	CDD:320185	17/26 (65%)
		TM helix 3	101..131	CDD:320185	16/29 (55%)
		TM helix 4	143..163	CDD:320185	6/19 (32%)
		TM helix 5	192..222	CDD:320185	8/29 (28%)
		TM helix 6	257..287	CDD:320185	16/29 (55%)
		TM helix 7	307..332	CDD:320185	12/25 (48%)