Protein Alignment 5-HT1B and adrb2b

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001082940.3
• Gene: adrb2b / 100037315
• ZFINID: ZDB-GENE-070410-32
• Length: 409
• Species: Danio rerio
• Alignment Length: 578
• Identity: 124/578 - (21%)
• Similarity: 198/578 - (34%)
• Gaps: 241/578 - (41%)

  Fly    38 LNGNLTQLVDTTSNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMIL 102
            :.|..|.:.:.||    :..|.|...|.:|.....|.:..:         .:::.:::::|:::|
Zfish     1 MEGENTLITENTS----LYMNISAGLNASSPVSLSVSEYSD---------AEVVLISILIGILVL 52

  Fly   103 VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWT 167
            |.:.||..||:||:..:.||.|.||.::|||.|||.:..:|:|.||.|.:.|.|..|...|:.||
Zfish    53 VIVFGNALVISAIVRFQRLQTVTNYFISSLACADLVMGLMVVPFGACYILLNTWHFGNFFCEFWT 117

  Fly   168 SCDVLCCTASILHLVAIAADRY----WTVTNIDYNNLRTPRRVFLMIFCVWFAALIVSLAP-QFG 227
            :.||||.||||..|..||.|||    |.   :.|.::.|.|:...|:..||..|.::|..| ...
Zfish   118 ATDVLCVTASIETLCVIALDRYIAIMWP---LRYQSMLTKRKACGMVIGVWAVAALISFLPIHME 179

  Fly   228 W---KDPDYMKRIEEQHCM-VSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKS 288
            |   .:|:.:..:||..|. .:.:..|.:.::..:||:||:::.|:|.:::..||:::|:
Zfish   180 WWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLVIMAFVYSRVFQEARRQLQK----- 239

  Fly   289 FNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTN 353
                                                                             
Zfish   240 ----------------------------------------------------------------- 239

  Fly   354 TANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNA 418
                                       |.|.|....|.:..                    |...
Zfish   240 ---------------------------IDRIEGRIRTQSLS--------------------TQEG 257

  Fly   419 NEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGS 483
            |||
Zfish   258 NEI-------------------------------------------------------------- 260

  Fly   484 GSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWL 548
                                               |.|:.....::.||.:||.||.|.|.:|||
Zfish   261 -----------------------------------KNRRTKFCMKDHKALKTLGIIMGTFTLCWL 290

  Fly   549 PFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGR 606
            ||||:.:..::.|...|.... .:..|:||.||..||:|| ..:||||.||:.||..|
Zfish   291 PFFVLNVVAAIWKMDNIMLPF-RILNWIGYANSAFNPLIY-CRSPEFRCAFQEILCWR 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	12/25 (48%)
		TM helix 3	163..193	CDD:320454	18/33 (55%)
		TM helix 4	204..226	CDD:320454	7/22 (32%)
		TM helix 5	247..276	CDD:320454	7/28 (25%)
		7tm_GPCRs	<525..599	CDD:475119	30/73 (41%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	9/24 (38%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	70/204 (34%)
adrb2b	NP_001082940.3	None