Protein Alignment 5-HT1B and taar12a

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001076578.1
• Gene: taar12a / 100034659
• ZFINID: ZDB-GENE-041014-99
• Length: 343
• Species: Danio rerio
• Alignment Length: 539
• Identity: 103/539 - (19%)
• Similarity: 159/539 - (29%)
• Gaps: 264/539 - (48%)

  Fly    86 LLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVY 150
            |.|..:.:.|.|.||||.|:.||:.:|.:|...::||:..:.:|.|||..|..:..||||...|.
Zfish    38 LAVVQVGLYVFLLLMILTTVFGNLMIIISISHFKHLQSPTHLIVQSLAACDCLMGSLVMPYSMVR 102

  Fly   151 EISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVW 214
            .:...|.||..:|.:..|.||..|.:|:|||..|:.|||..:.: :.|....|...:.:.|..:|
Zfish   103 SVEGCWYLGDVVCKVHFSFDVTFCISSLLHLCLISVDRYLAICDPLRYKIRVTNTTMTVFIIFIW 167

  Fly   215 FAALIVSLAPQF-GWKDPDYMKRIEEQHCMVSQDVGYQIFATC-------------CTFYVPLLV 265
            ..:::.|.:..| |.........|.:.:|:          .:|             .||::...:
Zfish   168 LFSVVYSFSIVFSGITAVGLEMLILQTYCV----------GSCVLFFNKEWAVYPFLTFFITGAI 222

  Fly   266 ILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGD 330
            :..||.||:.:|||                             .:|..:||.:
Zfish   223 MSSLYMKIFHVARK-----------------------------HAKVMSERVK------------ 246

  Fly   331 GTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDN 395
              ||...:|:
Zfish   247 --GGLKSQRS------------------------------------------------------- 254

  Fly   396 KSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLT 460
                                                                             
Zfish   255 ----------------------------------------------------------------- 254

  Fly   461 TTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLE 525
                                                                             
Zfish   255 ----------------------------------------------------------------- 254

  Fly   526 AKRERKAAQTLAIITGAFVICWLPFFVMALT-----MSLCKECEIHTAVASLFLWLGYFNSTLNP 585
            |:||||||:||||:.|.|:.||||:  .|.|     .:.....|    |..:..|..||||:.||
Zfish   255 AQRERKAAKTLAIVMGVFMFCWLPY--CAFTALYPFFTFLNSAE----VFDVLFWFAYFNSSCNP 313

  Fly   586 VIYTIFNPEFRRAFKRILF 604
            :||..|.|.|::|||.::|
Zfish   314 LIYGFFYPCFQKAFKILIF 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	11/25 (44%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	13/29 (45%)
		TM helix 4	204..226	CDD:320454	3/21 (14%)
		TM helix 5	247..276	CDD:320454	7/41 (17%)
		7tm_GPCRs	<525..599	CDD:475119	33/78 (42%)
		TM helix 6	533..555	CDD:410628	11/21 (52%)
		TM helix 7	567..592	CDD:410628	10/24 (42%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	58/210 (28%)
taar12a	NP_001076578.1	7tm_GPCRs	43..327	CDD:475119	97/527 (18%)
		TM helix 1	45..69	CDD:410628	11/23 (48%)
		TM helix 2	78..100	CDD:410628	9/21 (43%)
		TM helix 3	116..138	CDD:410628	9/21 (43%)
		TM helix 4	161..177	CDD:410628	3/15 (20%)
		TM helix 5	206..228	CDD:410628	3/21 (14%)
		TM helix 6	262..284	CDD:410628	12/23 (52%)
		TM helix 7	295..320	CDD:410628	11/28 (39%)