Protein Alignment 5-HT1B and htr1fa

DIOPT Version :9

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017213382.1
• Gene: htr1fa / 100005344
• ZFINID: ZDB-GENE-081105-125
• Length: 363
• Species: Danio rerio
• Alignment Length: 517
• Identity: 141/517 - (27%)
• Similarity: 204/517 - (39%)
• Gaps: 184/517 - (35%)

  Fly    90 MIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISN 154
            ::.:::.|..:.::|...|..||.|||:.|.|.:.:|||:.||||.||.||.||||...:|...:
Zfish    22 VVLLSLTLSFLAILTTAMNCLVITAIIVTRKLHHPSNYLICSLAVTDLLVAILVMPFSIIYIAKD 86

  Fly   155 GWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAAL 218
            .|::|..||..|.|.|:.|||.|||||.|||.|||..:|: ::|:..||..|..:||..||..|:
Zfish    87 TWLIGEALCKFWLSVDITCCTCSILHLAAIAVDRYRAITDAVEYSRKRTSLRAAIMISVVWLLAI 151

  Fly   219 IVSLAPQFGWKDPDYMKRIEEQHC-MVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQ 282
            ::||.|..       ::..||..| :|..::...:::|...||:||::||.||:|||..|:....
Zfish   152 VISLPPIL-------LRNGEENECIIVHTNIASMLYSTFGAFYIPLILILILYYKIYRAAKTLYH 209

  Fly   283 RRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRIC 347
            ||.....|               |.|.:           |...|...|
Zfish   210 RRRTSCLN---------------KSEMN-----------GHMLPKCSD----------------- 231

  Fly   348 FGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADD 412
                                               ||.|
Zfish   232 -----------------------------------REPT-------------------------- 235

  Fly   413 YRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAG 477
                                            ||             .|.:|.||::|...|...
Zfish   236 --------------------------------TP-------------DTLSPPEKSMSEPSTEGD 255

  Fly   478 AVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGA 542
            .|.                         :.|......::.:.||..:...||:|||.||.:|.||
Zfish   256 RVR-------------------------ITARSPKSRRERSLRRHRISNIREKKAATTLGLIIGA 295

  Fly   543 FVICWLPFFVMALTMSLCK-ECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            ||:||||||:..:..::|. .|....||.:...||||.||.:||:||||||.:|:|||::|:
Zfish   296 FVVCWLPFFIHEVIYNICTVSCSRSVAVTNFLTWLGYLNSLINPLIYTIFNEDFKRAFQKII 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	77/182 (42%)
htr1fa	XP_017213382.1	7tm_GPCRs	23..354	CDD:333717	139/511 (27%)
		TM helix 1	25..49	CDD:320095	7/23 (30%)
		TM helix 2	58..80	CDD:320095	15/21 (71%)
		TM helix 3	96..118	CDD:320095	13/21 (62%)
		TM helix 4	141..157	CDD:320095	7/15 (47%)
		TM helix 5	175..198	CDD:320095	8/22 (36%)
		TM helix 6	283..308	CDD:320095	16/24 (67%)
		TM helix 7	321..346	CDD:320095	14/24 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910