Protein Alignment 5-HT1B and drd7

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001107115.2
• Gene: drd7 / 100002285
• ZFINID: ZDB-GENE-060526-372
• Length: 443
• Species: Danio rerio
• Alignment Length: 530
• Identity: 119/530 - (22%)
• Similarity: 185/530 - (34%)
• Gaps: 231/530 - (43%)

  Fly    87 LVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFVACLVMPLGAVY 150
            |:.....|.:|.:.:|.|.:||..|..|::..|:|:: ||...|.||||:||.||.||||..|..
Zfish    12 LITRSTTACLLFIFVLSTFLGNALVCTAVVRFRHLRSKVAYVFVVSLAVSDLLVATLVMPWKAAA 76

  Fly   151 EISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVW 214
            ||...|..| ..|::|.:.|::|.|||||:|..|:.||||.:. .:.|....|.|..|:||...|
Zfish    77 EIVGFWPFG-SFCEVWIAFDIMCSTASILNLCIISVDRYWAIAIPLSYEQKMTRRVAFVMIGVAW 140

  Fly   215 FAALIVSLAP-QFGW-KDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIA 277
            ..::::|..| |..| |..|.::.:.|: |..|.:..|.|.::..:||:|:.:::..|.:|::||
Zfish   141 TLSVLISFIPVQLSWHKSLDPIEDLAEK-CDASLNRTYAITSSLISFYIPVSIMIVTYSRIFLIA 204

  Fly   278 RKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRK 342
            :::|:|.:.:..::...:: |.|.
Zfish   205 QRQIRRISMQECSIKHVQS-CQSC----------------------------------------- 227

  Fly   343 RMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVS 407
                                                                ||:
Zfish   228 ----------------------------------------------------NKA---------- 230

  Fly   408 SDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGA 472
                                                                    |.||..|
Zfish   231 --------------------------------------------------------PEEKLKS-- 237

  Fly   473 GTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLA 537
                                                                ..:||.|..:||:
Zfish   238 ----------------------------------------------------SFRRETKVLKTLS 250

  Fly   538 IITGAFVICWLPFFVMALTMSLCKECEIHTA---------VASLFLWLGYFNSTLNPVIYTIFNP 593
            :|.|.||.||||||::...:..| :..:|.|         ...:|:|.|:.|||||||:|. ||.
Zfish   251 MIMGVFVCCWLPFFILNCMVPFC-DPGLHNAGQIPCVNKTTFDVFVWCGWANSTLNPVVYA-FNA 313

  Fly   594 EFRRAFKRIL 603
            |||:||..||
Zfish   314 EFRKAFSSIL 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	8/25 (32%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	15/29 (52%)
		TM helix 4	204..226	CDD:320454	7/22 (32%)
		TM helix 5	247..276	CDD:320454	7/28 (25%)
		7tm_GPCRs	<525..599	CDD:475119	34/82 (41%)
		TM helix 6	533..555	CDD:410628	12/21 (57%)
		TM helix 7	567..592	CDD:410628	12/33 (36%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	72/199 (36%)
drd7	NP_001107115.2	None