DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1B and htr1aa

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001116793.1	Gene:	htr1aa / 100001828	ZFINID:	ZDB-GENE-071203-1	Length:	398	Species:	Danio rerio

Alignment Length:	538	Identity:	168/538 - (31%)
Similarity:	243/538 - (45%)	Gaps:	152/538 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 131
            :||.:..|......:|....|...|..::.|..:||..|:||..|||||.|||:||||||||:.|
Zfish     5 NNTTESQDWSGNATSVSEVALSYQIIGSLFLAALILFAILGNACVIAAIALERSLQNVANYLIGS 69

  Fly   132 LAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-I 195
            |||.||.|:.||:|:.|:|::.|.|.||.|:|||:.|.||||||:|||||.|||.||||.:|: |
Zfish    70 LAVTDLMVSVLVLPMAALYQVLNKWTLGQEMCDIFISLDVLCCTSSILHLCAIALDRYWAITDPI 134

  Fly   196 DYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFY 260
            ||.|.|||||..::|...|.....:|:.|..||:.|:  .|.:...|.:|||.||.|::|...||
Zfish   135 DYVNKRTPRRAAILISLTWLIGFSISIPPMLGWRKPE--DRADPDACTISQDHGYTIYSTFGAFY 197

  Fly   261 VPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERT 325
            :||:::|.||.:|:..||.||:                    :.:||....:.|::....:....
Zfish   198 IPLILMLVLYGRIFRAARFRIR--------------------KTVKKTEKAKIADKCLAVSPALF 242

  Fly   326 PVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFST 390
            |...:|..|:..||                :|...:.||:..|
Zfish   243 PRKANGEVGKTWRR----------------SVEPCANGALKNS---------------------- 269

  Fly   391 SNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGG 455
              .|.:|...||:.::|                         ::||             |:....
Zfish   270 --DDGESFEITEVQSIS-------------------------KNHL-------------SLPNNP 294

  Fly   456 VGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKR 520
            ..|                                                   ..|.::|..:.
Zfish   295 QPC---------------------------------------------------FENRNEKNTEA 308

  Fly   521 RQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNP 585
            ::.:...||||..:||.||.|.|:.||||||::||.:..|::|.:...:.::..||||.||.|||
Zfish   309 KRKVALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCQDCFMPEWLGAVINWLGYSNSLLNP 373

  Fly   586 VIYTIFNPEFRRAFKRIL 603
            |||..||.:|:.|||:||
Zfish   374 VIYAYFNKDFQNAFKKIL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	95/181 (52%)
htr1aa	NP_001116793.1	7tm_4	39..>161	CDD:304433	72/121 (60%)
htr1aa	NP_001116793.1	7tm_1	45..376	CDD:278431	148/481 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595731
Domainoid	1	1.000	279	1.000	Domainoid score	I1659
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2621
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830