DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and emb1974

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_187362.3	Gene:	emb1974 / 819892	AraportID:	AT3G07060	Length:	774	Species:	Arabidopsis thaliana

Alignment Length:	408	Identity:	87/408 - (21%)
Similarity:	150/408 - (36%)	Gaps:	98/408 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1138 SARDTHAGSSTSSSAAASSSHAHG------------YGSGTSGSSGRSTASDVSRRLSLGL-PLR 1189
            |.|..|....:..|:...|.:.||            ......|.....:.:.|.:|.|.|. .:|
plant     2 SNRSLHLKKISWLSSRILSDNVHGRFRRSITTPATCLAPSLDGDMNIGSKTLVEQRFSRGFASVR 66

  Fly  1190 QANELASSDDDGSKNGLGSPTSPTV-AAAVAAAGITGAAGTIPKQVYLRK---RQQLFQ------ 1244
            :.:..:||..       .||:||.| ..:...|.:....|  |...:|.:   .:|||:
plant    67 RVSRASSSSS-------SSPSSPHVDLLSFIKASLDKLEG--PSHHWLNRDFGNKQLFKDKGTYV 122

  Fly  1245 ------LGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSN----GIFVKEFGEYG--N 1297
                  |.|.....|.|...:.|.........:....:.:.::.|..    .:.:||:..:.  .
plant   123 VLAGHLLDGTSDLSGFFEKLKLLQQRSPGVCFMGIHFSDQARIADDRTALAELILKEYLTFPVLL 187

  Fly  1298 GEGEFDCLAGVAVNRIGQYIIADRYNHRI----QVLDPQG--RFLRAFGSQGTADGK----FNYP 1352
            .|.||...:|..     :||:...:.:.:    :.||...  :.|.:..:|.|...|    |...
plant   188 SEKEFPKTSGEV-----RYIVFKDFKNPLIYEEKDLDIASVVKALDSLLTQDTEKSKSVRLFTNT 247

  Fly  1353 WGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNT-NRVIVSDSN 1416
            |....:|:       ||:|....||               :..|..|..|:.... :|:.:||:|
plant   248 WSKQAEAI-------KESHFPSFFQ---------------DLLLYFPGCISADEVGDRLFLSDTN 290

  Fly  1417 NHRIQIFDVNGKVLSTVG-GEGSDDGQFKF-----PRGVAVDD-QGYIFVADSGNNRIQIFNPDG 1474
            :|||.||:.:||::.::| ..|.:||.|:.     |.|...|: :..:::.||.|:.|:..|.:.
plant   291 HHRIIIFENSGKIVDSIGCFPGFEDGDFESAKMLRPTGTLYDEAEDCLYIVDSENHAIRRANINS 355

  Fly  1475 SFL---------KTFGSW 1483
            ..|         ||.|.|
plant   356 RVLETVYPKVIKKTGGLW 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	64/298 (21%)
		YncE	1253..>1517	CDD:225926	58/264 (22%)
		NHL repeat	1258..1297	CDD:271324	4/44 (9%)
		WD40 repeat	1261..1304	CDD:293791	7/48 (15%)
		NHL repeat	1305..1344	CDD:271324	7/44 (16%)
		WD40 repeat	1345..1377	CDD:293791	7/35 (20%)
		NHL repeat	1352..1388	CDD:271324	7/35 (20%)
		NHL repeat	1396..1436	CDD:271324	15/41 (37%)
		WD40 repeat	1402..1439	CDD:293791	14/38 (37%)
		NHL repeat	1445..1475	CDD:271324	8/35 (23%)
		WD40 repeat	1446..1485	CDD:293791	13/48 (27%)
		NHL repeat	1491..1517	CDD:271324
emb1974	NP_187362.3	NHL	<264..>361	CDD:302697	30/111 (27%)
		NHL repeat	272..309	CDD:271320	13/36 (36%)
		NHL repeat	318..361	CDD:271320	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24104
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100