DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and TRIM56

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_112223.1	Gene:	TRIM56 / 81844	HGNCID:	19028	Length:	755	Species:	Homo sapiens

Alignment Length:	497	Identity:	101/497 - (20%)
Similarity:	169/497 - (34%)	Gaps:	156/497 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQ 72
            |.|.:||::.|.||.|||.|::|.: |:..|.|..|  |:|||||....:|..||.:|.||..:.
Human    19 LACKICLEQLRAPKTLPCLHTYCQD-CLAQLADGGR--VRCPECRETVPVPPEGVASFKTNFFVN 80

  Fly    73 RFLEL-HIEITGEL--------------PDPTSGQIMERCGVCSE-------------------- 102
            ..|:| .....|:|              ...|.|....||..|::
Human    81 GLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQTHTHR 145

  Fly   103 -----------------------------KAYLSHCAHCEKKICEDCK-SAHMDILRREITRFNS 137
                                         :|....|..|.:.:|.:|: ..|:|   ........
Human   146 VVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQPCSQLLCRECRLDPHLD---HPCLPLAE 207

  Fly   138 QIRRSLHRLQDSLAIIEKNTMSLQTNAISVTEEIDEIYQRITK----AIKDRSDQLKGEIDRYLA 198
            .:|.....|:..||.::.|.:.|            |..:|:.|    .:::::.::..:::....
Human   208 AVRARRPGLEGLLAGVDNNLVEL------------EAARRVEKEALARLREQAARVGTQVEEAAE 260

  Fly   199 VELRNLTTLKENLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENND 263
            ..||.|...|:.:   :..:.::.:..::...|.:    .||...:::......|
Human   261 GVLRALLAQKQEV---LGQLRAHVEAAEEAARERL----AELEGREQVARAAAAF---------- 308

  Fly   264 YSRRVRFL------VSIDPNQLVMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKS 322
             :|||..|      :|:: ..:...|........||...|.        |.|...|.|||: .|:
Human   309 -ARRVLSLGREAEILSLE-GAIAQRLRQLQGCPWAPGPAPC--------LLPQLELHPGLL-DKN 362

  Fly   323 DHRLATQF-RQQEERSGYNDEPVLGGRKFGERPQ-RSATQANNDRYG------------------ 367
            .|.|...| .||.::.|..|.   .|.:.||..| |...:...:|.|
Human   363 CHLLRLSFEEQQPQKDGGKDG---AGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPKEEKA 424

  Fly   368 ---RSGGDYDYEND-----YDNEG----SSGRAGKSSRFRSR 397
               |..|....|.|     :::.|    ..||..|..:|:.|
Human   425 QTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGR 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	21/44 (48%)
		zf-B_box	94..>122	CDD:279037	8/77 (10%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	13/103 (13%)
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
TRIM56	NP_112223.1	RAD18	8..>214	CDD:333230	45/200 (23%)
		RING-HC_TRIM56_C-V	19..60	CDD:319498	20/43 (47%)
		RING-HC finger (C3HC4-type)	21..59	CDD:319498	18/40 (45%)
		BBOX	169..205	CDD:237988	7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..484		21/99 (21%)
		NHL	521..748	CDD:302697
		WD40 repeat	593..627	CDD:293791
		NHL repeat	598..626	CDD:271320
		NHL repeat	634..674	CDD:271320
		WD40 repeat	635..672	CDD:293791
		WD40 repeat	681..720	CDD:293791
		NHL repeat	681..714	CDD:271320
		NHL repeat	723..748	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920