DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and Trim32

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001155254.1	Gene:	Trim32 / 69807	MGIID:	1917057	Length:	655	Species:	Mus musculus

Alignment Length:	577	Identity:	132/577 - (22%)
Similarity:	214/577 - (37%)	Gaps:	161/577 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   998 GTGDDSDSRYGTGRSRYLAMKERRTR--LARSRSSHQFGNDDEDLDEPVSPTTVSPSAYL----- 1055
            |...|..:||......| ..:|||.:  |||||   :|........|..:...|...:||
Mouse   173 GVSRDLQARYKAVLQEY-GHEERRIQEELARSR---KFFTGSLAEVEKSNSQVVEEQSYLLNIAE 233

  Fly  1056 ---ASRCAYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWA 1117
               .|||.|.      |::      :|..|.:.:.:               |.|.::.|..:|..
Mouse   234 VQAVSRCDYF------LAK------IKQADVALLEE---------------TADEEEPELTASLP 271

  Fly  1118 RYLKNKYGNKSSKDSAGSSGSARDT------HAGSSTSSSAAAS--SSHAHGYGSGTSGSSGRST 1174
            |.|                 :.:|.      |.|......|...  :.:.....:|..|::..::
Mouse   272 REL-----------------TLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAGEEGAASSAS 319

  Fly  1175 ASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSP--TSPTVAAAVAAAGITGAAGTIPKQVYLR 1237
            ||...|.:.:                       ||  .:|:..|:.|....:.||..|.:.::|:
Mouse   320 ASVTFREMDM-----------------------SPEEVAPSPRASPAKQRSSEAASGIQQCLFLK 361

  Fly  1238 KRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEF 1302
            |      :|.:||.||.|..|..|.|...:.::|||..|:|:|||:..| |:||.....:|...|
Mouse   362 K------MGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKG-FLKEIRRSPSGIDSF 419

  Fly  1303 DCLA------------GVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGV 1355
             .|:            .||:|..|...:.|.|::.::|....|..:....||      .:.|||:
Mouse   420 -VLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTMDGHCVACHRSQ------LSKPWGI 477

  Fly  1356 TTDALGFIYVCDKENHRVQVFQSD-GSFV-----------GKFGSCGRGEGQLEHPHYIAVSNTN 1408
            |....|...|.|.|..::..|..| |:.|           .||.:|. .||.:.....:.::..|
Mouse   478 TALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCD-AEGTVYFTQGLGLNVEN 541

  Fly  1409 RVIVSDSNNHRIQIFDVNGKVLSTVGGEG----------SDDGQFKFPRGVAVDDQGYIFVADSG 1463
            |     .|.|.::    .|..:.:||.:|          |::..|:...|:.||.:|.:.||||.
Mouse   542 R-----QNEHHLE----GGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSS 597

  Fly  1464 NNRIQIFNPDGSFLKTFGSWGSGDSEFKGLE---GVAIMSNGNILVCDRENHRVQVF 1517
            ...|..|...|.:.....         :||.   |:|:...|.:||.|..:|.|:::
Mouse   598 RKEILHFPKGGGYSVLIR---------EGLTCPVGIALTPKGQLLVLDCWDHCVKIY 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	84/319 (26%)
		YncE	1253..>1517	CDD:225926	78/300 (26%)
		NHL repeat	1258..1297	CDD:271324	15/38 (39%)
		WD40 repeat	1261..1304	CDD:293791	16/42 (38%)
		NHL repeat	1305..1344	CDD:271324	11/50 (22%)
		WD40 repeat	1345..1377	CDD:293791	8/31 (26%)
		NHL repeat	1352..1388	CDD:271324	14/47 (30%)
		NHL repeat	1396..1436	CDD:271324	7/39 (18%)
		WD40 repeat	1402..1439	CDD:293791	8/46 (17%)
		NHL repeat	1445..1475	CDD:271324	10/29 (34%)
		WD40 repeat	1446..1485	CDD:293791	11/38 (29%)
		NHL repeat	1491..1517	CDD:271324	10/28 (36%)
Trim32	NP_001155254.1	RING-HC_TRIM32_C-VII	20..66	CDD:319501
		RING-HC finger (C3HC4-type)	21..65	CDD:319501
		Bbox1_TRIM32_C-VII	99..139	CDD:380864
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..347		5/42 (12%)
		NHL 1	360..403		19/48 (40%)
		NHL_TRIM32_like	364..646	CDD:271331	82/309 (27%)
		NHL repeat	376..416	CDD:271331	15/40 (38%)
		NHL 2	417..460		9/43 (21%)
		NHL repeat	433..472	CDD:271331	10/44 (23%)
		NHL 3	461..501		12/45 (27%)
		NHL repeat	474..514	CDD:271331	12/39 (31%)
		NHL repeat	515..566	CDD:271331	13/60 (22%)
		NHL 4	564..607		12/42 (29%)
		NHL repeat	579..611	CDD:271331	11/31 (35%)
		NHL 5	608..648		11/47 (23%)
		NHL repeat	619..645	CDD:271331	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920