DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and ftr51

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_009299323.1	Gene:	ftr51 / 562700	ZFINID:	ZDB-GENE-081104-54	Length:	544	Species:	Danio rerio

Alignment Length:	287	Identity:	63/287 - (21%)
Similarity:	104/287 - (36%)	Gaps:	70/287 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQ--VKCPECRAEHRIPYNGVQAFPTNVTL 71
            ||.||||..:.|..:||.||:| :.|:....|....:  ..||:||....:.    .|...|..|
Zfish    12 TCPVCLDLLKHPAAIPCGHSYC-KSCITDCWDQEEEKGVYSCPQCRQTFSLR----PALAKNTIL 71

  Fly    72 QRFLELHIEITGELPDPTSGQIMERCGVCSEKAY--LSHCAHCEKKICEDCKSAHMDIL---RRE 131
            ...:| .::.|....|..:|.:  .|.||:...|  :..|..|....||.....|..:.   |..
Zfish    72 AEVVE-KLKKTKPPADCCAGDV--PCDVCTGGKYTAVKSCLVCLSSYCESHLEQHESLFKGKRHR 133

  Fly   132 ITRFNSQIRRSLHRLQDSLAII-----------------EKN--TMSLQTNAISVTEEIDEIYQR 177
            :|....:::..:....|.|..:                 .||  |:|.........:::.|...:
Zfish   134 LTEATGRLQEMICHDHDKLLEVFCRTDQKCICLLCTMDEHKNHDTVSAAAQRTESQKQMKETQSK 198

  Fly   178 ITKAIKDRSDQLKGEIDRYLAVELRNLTTLKENLDLEITNITSNCDTVDKYMNETVEWDDCELMD 242
            |.:.|:.|.               |:|..|||.::..            |...:|.      :.|
Zfish   199 IQERIQQRE---------------RDLQQLKEAVESH------------KRSAQTA------VED 230

  Fly   243 TKEIFLKTVEFLRHFEYENNDYSRRVR 269
            ||.||   .|.::|.|...::.:|::|
Zfish   231 TKRIF---TELIQHIERSRSEVTRQIR 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	18/46 (39%)
		zf-B_box	94..>122	CDD:279037	8/29 (28%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	17/118 (14%)
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
ftr51	XP_009299323.1	RING	13..55	CDD:302633	15/42 (36%)
		zf-B_box	142..180	CDD:279037	5/37 (14%)
		NtpH	184..291	CDD:225368	21/107 (20%)
		DUF4200	186..301	CDD:290574	21/105 (20%)
		SPRY_PRY_SNTX	363..544	CDD:294002
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030