DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and trim3a

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_686295.4	Gene:	trim3a / 562489	ZFINID:	ZDB-GENE-080522-4	Length:	774	Species:	Danio rerio

Alignment Length:	800	Identity:	204/800 - (25%)
Similarity:	318/800 - (39%)	Gaps:	156/800 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 QNAKAPSSSRYS--TARDTTAVPEKKPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSSES 855
            ||...|.|...|  ..|.|:.:|||           ..|:..|........|.....::.|.||:
Zfish    52 QNYIPPQSLTLSCPVCRQTSILPEK-----------GVAALQNNFFITNLMEVLQREQDCTRSEA 105

  Fly   856 ESESEPETKAKSSATSSTTNTKSTPNS--------AASSTTAASSSTTSGSY--------RDRLE 904
            .|..|      |:..::.....|.||.        ..|..||.....|.|.:        ||.||
Zfish   106 SSGLE------SAGAATYAPPLSCPNHEGKVMEFYCESCETAMCLECTEGEHREHVTVPLRDVLE 164

  Fly   905 ARRASRDDSSSTAAGRSSYATPSSSGYGS-GSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSYTS 968
            ..:|:..:.......|....|.:...... ....|..:..||....:|.|..::......::..:
Zfish   165 QHKAALKNQLDAIRNRLPQLTAAIELVNEISKQLTDRKNEAVTEISNTFEELEKALHQRKTTLIT 229

  Fly   969 RFLNKSKSSAIVTQPSLST---------PTASFDEDATGTGDDSDSRYGTGRSRYLAMK---ERR 1021
            ...|...:...|.|..|:.         .:.||.|.|...|..::.        .|..|   ||.
Zfish   230 DLENICSTKQKVLQGQLAALMQGKENIQSSCSFTEQALNHGSPTEV--------LLVQKQMGERM 286

  Fly  1022 TRLAR---SRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRSRS-SHALKSRD 1082
            ..|||   ....|:.|:.|..::......::.....|.:.   |..|.:.::.... .||:..:
Zfish   287 GALARHAFPEQPHENGHLDCQVETEGLRRSIQNLGVLLTT---SSVGHTSVATGEGLRHAVVGQ- 347

  Fly  1083 NSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSSK-DSAGSSGSARDTHAGS 1146
            |:.:|               .||..||||.:         |.||.:.: ..:|:.|...:|....
Zfish   348 NTTVT---------------VTTKDKDGELV---------KTGNAALRAQISGADGGVTETDVTD 388

  Fly  1147 STSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSLGLPLR----QANELASSDDDGSKNGLG 1207
            :      .:.::..||...:.|....|..  :..|...|.|.|    :|.:...|.|| .|..:.
Zfish   389 N------KNGTYEIGYTLRSEGEFSFSVL--LYGRHVRGSPFRLRAVKACDAPQSPDD-VKRRVK 444

  Fly  1208 SPTSPTVAAAVAAAGITGAAGTI-------PKQVY--LRKRQQ------LFQLGGRGSEPGSFTW 1257
            ||           .|..||.|.:       |..:|  .:|::.      :|::|.||.|.|.|:.
Zfish   445 SP-----------GGGGGAGGHVRQKAVRRPSSMYSTTKKKENPIEDELIFRVGTRGRERGEFSN 498

  Fly  1258 PRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRY 1322
            .:|::......||||||:|..:|||.::|.|..:||..|...|:.....||||:..|..|:||..
Zfish   499 LQGISTTSSGRIVVADSNNQCIQVFSNDGQFKLKFGVRGRSPGQLQRPTGVAVDMNGDIIVADYD 563

  Fly  1323 NHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFG 1387
            |..:.:..|.|:|....|:     |:...|.||..|..|.|...|.:...|.:|||:|..|.|||
Zfish   564 NRWLSIFSPDGKFKNKIGA-----GRLMGPKGVAVDKNGHIITADNKACCVFIFQSNGKLVTKFG 623

  Fly  1388 SCGRGEGQLE--------------------HPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLST 1432
            :.|..|.|..                    .||::|::|.|.::|:|.:||.:::::.:|:.|..
Zfish   624 AKGTSERQFADKSAPNTPTEPKQSKSGPAFSPHFVAINNKNEIVVTDFHNHSVKVYNADGEFLFK 688

  Fly  1433 VGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSEFKGLEGVA 1497
            .|..|..:|||..|.|||||..|.|.|||.||:|||:|:..||||....:  :.|..: |.:|:|
Zfish   689 FGSHGEGNGQFNAPTGVAVDGNGNIIVADWGNSRIQVFDSSGSFLSYINT--TADPLY-GPQGLA 750

  Fly  1498 IMSNGNILVCDRENHRVQVF 1517
            :.|:|::.|.|..||..:|:
Zfish   751 LTSDGHVAVADSGNHCFKVY 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	106/310 (34%)
		YncE	1253..>1517	CDD:225926	99/283 (35%)
		NHL repeat	1258..1297	CDD:271324	15/38 (39%)
		WD40 repeat	1261..1304	CDD:293791	16/42 (38%)
		NHL repeat	1305..1344	CDD:271324	13/38 (34%)
		WD40 repeat	1345..1377	CDD:293791	9/31 (29%)
		NHL repeat	1352..1388	CDD:271324	15/35 (43%)
		NHL repeat	1396..1436	CDD:271324	12/59 (20%)
		WD40 repeat	1402..1439	CDD:293791	11/36 (31%)
		NHL repeat	1445..1475	CDD:271324	17/29 (59%)
		WD40 repeat	1446..1485	CDD:293791	21/38 (55%)
		NHL repeat	1491..1517	CDD:271324	9/25 (36%)
trim3a	XP_686295.4	RING	27..70	CDD:238093	6/17 (35%)
		BBOX	118..159	CDD:197662	8/40 (20%)
		BBC	166..291	CDD:128778	22/132 (17%)
		IG_FLMN	333..429	CDD:214720	24/128 (19%)
		Filamin	333..423	CDD:279024	23/122 (19%)
		NHL_TRIM2_like	481..774	CDD:271330	105/297 (35%)
		YncE	496..>765	CDD:225926	96/276 (35%)
		NHL repeat	499..538	CDD:271330	15/38 (39%)
		NHL repeat	546..585	CDD:271330	14/43 (33%)
		NHL repeat	588..625	CDD:271330	16/36 (44%)
		NHL repeat	632..693	CDD:271330	12/60 (20%)
		NHL repeat	699..741	CDD:271330	22/43 (51%)
		NHL repeat	744..770	CDD:271330	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2861
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.070