DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and Trim3

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001347354.1	Gene:	Trim3 / 55992	MGIID:	1860040	Length:	750	Species:	Mus musculus

Alignment Length:	799	Identity:	204/799 - (25%)
Similarity:	298/799 - (37%)	Gaps:	183/799 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 QNAKAPSSSRYS--TARDTTAVPEKKPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSSES 855
            ||...|.|...|  ..|.|:.:||:                  |.:..:.....||..|......
Mouse    47 QNYIPPQSLTLSCPVCRQTSILPEQ------------------GVSALQNNFFISSLMEAMQQAP 93

  Fly   856 ESESEPETKAKSSATSSTTNTKSTPNS--------------AASSTTAASSSTTSGSY------- 899
            |...:||.....||.:.  ...|.||.              ..:..||......:|.:
Mouse    94 EGAHDPEDPHPLSAVAG--RPLSCPNHEGKEPLYHQTMEFYCEACETAMCGECRAGEHREHGTVL 156

  Fly   900 -RDRLEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTG 963
             ||.:|..:|:.........||....:.:.:..|..|.....| :|......::..||
Mouse   157 LRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQER-KAEALAQISAAFED------- 213

  Fly   964 SSYTSRFLNKSKSSAI------------VTQPSLST---------PTASFDEDATGTGDDSDSRY 1007
               ..:.|.:.|.:.:            |.|..|.|         .:.||.|.|.        |.
Mouse   214 ---LEQALQQRKQALVSDLESICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQAL--------RL 267

  Fly  1008 GTGRSRYLAMKERRTRLARSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRS 1072
            |:.....|..|..|.|||.             |.....|.....:|.|.......|...|.|:
Mouse   268 GSAPEVLLVRKHMRERLAA-------------LAAQAFPERPHENAQLELVLEVDGLRRSVLN-- 317

  Fly  1073 RSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSS-----KDS 1132
                                      ||...||.:...|.:::.....:...|..:|     ||.
Mouse   318 --------------------------LGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDK 356

  Fly  1133 AG---SSGSAR--DTHAGSSTSSSAAASSSHAHG-----YGSGTSGSSGRSTASDVSRRLSLGLP 1187
            .|   .:|||.  ....|......|.....|.:|     |.:.|.|....|.       |..|.|
Mouse   357 DGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTYELVYTARTEGDLLLSV-------LLYGQP 414

  Fly  1188 LR---------QANELASSDDDGSKNGLGSPTSPTVAAAVAAAGITGAAGTIPKQVYLR--KRQQ 1241
            :|         :..:|..|.|| .|..:.||..|       .:.:...|...|..:|..  ||:.
Mouse   415 VRGSPFRVRALRPGDLPPSPDD-VKRRVKSPGGP-------GSHVRQKAVRRPSSMYSTGGKRKD 471

  Fly  1242 -------LFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGE 1299
                   :|::|.||.|.|.||..:|::......||||||:|..:|||.:.|.|...||..|...
Mouse   472 NPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSP 536

  Fly  1300 GEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIY 1364
            |:.....||||:..|..|:||..|..:.:..|:|:|....|:     |:...|.||..|..|.|.
Mouse   537 GQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGA-----GRLMGPKGVAVDRNGHII 596

  Fly  1365 VCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKV 1429
            |.|.::..|..||.:|..||:||..|..:.....||::||:|.|.::|:|.:||.::::..:|:.
Mouse   597 VVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEF 661

  Fly  1430 LSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSE-FKGL 1493
            |...|..|..:|||..|.|||||..|.|.|||.||:|||:|:..||||    |:.:..:| ..|.
Mouse   662 LFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFL----SYINTSAEPLYGP 722

  Fly  1494 EGVAIMSNGNILVCDRENH 1512
            :|:|:.|:|:::|.|..||
Mouse   723 QGLALTSDGHVVVADAGNH 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	108/289 (37%)
		YncE	1253..>1517	CDD:225926	100/261 (38%)
		NHL repeat	1258..1297	CDD:271324	15/38 (39%)
		WD40 repeat	1261..1304	CDD:293791	16/42 (38%)
		NHL repeat	1305..1344	CDD:271324	13/38 (34%)
		WD40 repeat	1345..1377	CDD:293791	10/31 (32%)
		NHL repeat	1352..1388	CDD:271324	15/35 (43%)
		NHL repeat	1396..1436	CDD:271324	13/39 (33%)
		WD40 repeat	1402..1439	CDD:293791	12/36 (33%)
		NHL repeat	1445..1475	CDD:271324	17/29 (59%)
		WD40 repeat	1446..1485	CDD:293791	22/38 (58%)
		NHL repeat	1491..1517	CDD:271324	9/22 (41%)
Trim3	NP_001347354.1	RING-HC_TRIM3	19..63	CDD:319682	5/15 (33%)
		RING-HC finger (C3HC4-type)	22..62	CDD:319682	5/14 (36%)
		Bbox_SF	107..159	CDD:381767	7/53 (13%)
		BBC	164..290	CDD:128778	28/157 (18%)
		Filamin	323..424		23/107 (21%)
		IG_FLMN	328..425	CDD:214720	21/103 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..470		12/52 (23%)
		NHL_TRIM2_like	477..750	CDD:271330	105/274 (38%)
		NHL 1	479..522		19/42 (45%)
		NHL repeat	495..534	CDD:271330	15/38 (39%)
		NHL 2	526..569		13/42 (31%)
		NHL repeat	542..581	CDD:271330	14/43 (33%)
		NHL 3	570..611		15/45 (33%)
		NHL repeat	584..621	CDD:271330	16/36 (44%)
		NHL 4	615..658		15/42 (36%)
		NHL repeat	628..669	CDD:271330	13/40 (33%)
		NHL 5	662..705		23/42 (55%)
		NHL repeat	675..717	CDD:271330	23/45 (51%)
		NHL 6	706..749		15/40 (38%)
		NHL repeat	720..746	CDD:271330	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2854
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43444
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	1	1.000	-	-		X1654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.100