DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and trim2b

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_009304581.1	Gene:	trim2b / 558046	ZFINID:	ZDB-GENE-090312-70	Length:	669	Species:	Danio rerio

Alignment Length:	827	Identity:	197/827 - (23%)
Similarity:	304/827 - (36%)	Gaps:	223/827 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 QRSGSSDSSASTESSASSAAAAAVAATSTSATAAA-------PATSSSNSTSQNAKAPSSS-RYS 804
            |.|..|.|...|...|......|:..:......:|       .|........::|:.|:.| ..:
Zfish     5 QASPDSSSEECTVLEALPGKGTALICSQHKGKVSALYCLVCENAVCEDCMNGEHAEHPTDSLEKA 69

  Fly   805 TARDTTAVPEKKPFVSRFLPQ-HSTASTTNGSADKKKAESSSSSEEETSSESESESEPETK---- 864
            ..:...|:.:|.......||| ............:..::.||..|:..||.||.....:|:
Zfish    70 VDQQLAALQDKVDSAKNRLPQIREAVQYLREILQQLNSQRSSIEEDIHSSFSELHKTLDTRKSVL 134

  Fly   865 ---------AKSSATSSTTNTKSTPNSAAS-STTAASSSTTSGSYRDRLEARRASRDDSSSTAAG 919
                     .|.....:..:|.....||.: :.:..|.:...||....|:|.:    ::......
Zfish   135 LMELEVTYGLKQKVLQAQLDTLLQEESAINYNCSLTSEALDGGSKASVLQAHK----EAGERLGD 195

  Fly   920 RSSYATP------------------SSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSS- 965
            .||...|                  ..|.:..|:..|   |.||     .|::|   .||.|..
Zfish   196 LSSQGLPLQPEENDQLDLMMEIEGLRKSIHNLGTIVT---TNAV-----ASQTE---ASGDGLEQ 249

  Fly   966 ----------YTSRFLNKS----KSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTGRSRYLA 1016
                      .|:|  :|:    |:...:....:.||..|..:     |:..|.:.||...:|..
Zfish   250 CIVGQPASVIITTR--DKAGGLCKTGNAIISAEVYTPDGSIAD-----GEIVDMKNGTYEFQYTV 307

  Fly  1017 MKERRTRLA-RSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRSRSSHALKS 1080
            .||....|| |....|..|          ||..:..|:                          |
Zfish   308 KKEGNFSLALRLYDQHIKG----------SPFQLKVSS--------------------------S 336

  Fly  1081 RDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHAG 1145
            .|:||.|...|         .:::|.|.||.|             .|.|..|.||....:....|
Zfish   337 PDDSPTTTTAA---------NAASTGSSDGGA-------------RKRSAKSPGSRSRQKGVRRG 379

  Fly  1146 SSTSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSPT 1210
            .|..|:                                   |.::.|.:   :||
Zfish   380 GSLFST-----------------------------------PKKRVNPI---EDD---------- 396

  Fly  1211 SPTVAAAVAAAGITGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSS 1275
                                          .:|::|.:|...|.||..:|:|...:..|::|||:
Zfish   397 ------------------------------LIFRIGTKGRNKGEFTNLQGVAACSEGRILIADSN 431

  Fly  1276 NHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFG 1340
            |..||:|.:.|.|...||..|...|:.....||||:..|..||||..|..:.:...:|::....|
Zfish   432 NQCVQIFSNTGEFQSRFGVRGRSPGQLQRPTGVAVHPNGDIIIADYDNKWVSIFSSEGKYKAKLG 496

  Fly  1341 SQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVS 1405
            |     |:...|.||:.|..|.:.|.|.:...|.:||..|..:.||||.|.|:.|...||:.||:
Zfish   497 S-----GRLMGPKGVSVDQNGHVIVVDNKACTVFIFQPSGKLITKFGSRGNGDRQFAGPHFAAVN 556

  Fly  1406 NTNRVIVSDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIF 1470
            |.|.:|::|.:||.:::|:.:|:.|...|..|..:|||..|.|||||..|.|.|||.||:|||:|
Zfish   557 NNNEIIITDFHNHSVKVFNADGEFLLKFGSNGEGNGQFNAPTGVAVDVNGNIIVADWGNSRIQVF 621

  Fly  1471 NPDGSFLKTFGSWGSGDSEFKGLEGVAIMSNGNILVCDRENHRVQVF 1517
            :..||||....:  :.|..: |.:|:|:.|:|:::|.|..||..:|:
Zfish   622 DGSGSFLSYINT--AADPLY-GPQGLALTSDGHVVVADSGNHCFKVY 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	103/282 (37%)
		YncE	1253..>1517	CDD:225926	100/263 (38%)
		NHL repeat	1258..1297	CDD:271324	14/38 (37%)
		WD40 repeat	1261..1304	CDD:293791	15/42 (36%)
		NHL repeat	1305..1344	CDD:271324	13/38 (34%)
		WD40 repeat	1345..1377	CDD:293791	9/31 (29%)
		NHL repeat	1352..1388	CDD:271324	13/35 (37%)
		NHL repeat	1396..1436	CDD:271324	14/39 (36%)
		WD40 repeat	1402..1439	CDD:293791	13/36 (36%)
		NHL repeat	1445..1475	CDD:271324	17/29 (59%)
		WD40 repeat	1446..1485	CDD:293791	21/38 (55%)
		NHL repeat	1491..1517	CDD:271324	9/25 (36%)
trim2b	XP_009304581.1	zf-B_box	29..66	CDD:279037	4/36 (11%)
		iSH2_PI3K_IA_R	73..199	CDD:304922	23/129 (18%)
		IG_FLMN	237..334	CDD:214720	26/116 (22%)
		Filamin	237..329	CDD:279024	25/111 (23%)
		NHL_TRIM2_like	396..669	CDD:271330	105/318 (33%)
		NHL repeat	414..453	CDD:271330	14/38 (37%)
		YncE	415..>660	CDD:225926	95/252 (38%)
		NHL repeat	461..500	CDD:271330	14/43 (33%)
		NHL repeat	503..540	CDD:271330	14/36 (39%)
		NHL repeat	547..588	CDD:271330	14/40 (35%)
		NHL repeat	594..636	CDD:271330	22/43 (51%)
		NHL repeat	639..665	CDD:271330	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2861
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.070