DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tn and mei-P26

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_001356936.1 Gene:mei-P26 / 45775 FlyBaseID:FBgn0026206 Length:1310 Species:Drosophila melanogaster


Alignment Length:1606 Identity:273/1606 - (16%)
Similarity:470/1606 - (29%) Gaps:683/1606 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 CCVCLDRYRIPKLLPCQHSFCMEPCMEGLV------------------DYVRRQ-------VKCP 49
            |.:|..|..:|::|.|.|.|| |.|::.:|                  |....|       ::||
  Fly   161 CKLCSLRLVMPRILSCLHVFC-EDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECP 224

  Fly    50 ECRAEHRIPYNGVQAFPTNVTLQRFLEL-HIEITGELPDPTSGQIMERCGVC-SEKAYLSHCAHC 112
            .|:.|..:...|::|.|.:..:...|:| ::|         |..|:  |..| |::..:|.|..|
  Fly   225 VCKQET
PLGPKGIKALPCDYIVTNILDLSNLE---------SEHIV--CTSCKSKEEAISRCNDC 278

  Fly   113 EKKICEDCKSAHM--------DILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAISVTE 169
            ...:|..|.:||.        .::|.|      .:.:::|   |.| ||.|.....|    .|:|
  Fly   279 ANFLCNGCDNAHKYMRCFENHHVVRIE------DLTKNVH---DKL-IIHKPVFCPQ----HVSE 329

  Fly   170 EI-----------------------DEIYQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLKE-- 209
            .:                       |..|:..|.|    ...::.:::..|:..|:......:  
  Fly   330 NLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVA----EQAVRADLEETLSDTLKKADYCNDAG 390

  Fly   210 -NLDLEITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLKTVEFLRHFEYENNDYSRRVRFLVS 273
             ||...:|.:.|..|||.:.:.:..:.....|...|:..|..:..|      ::|...::..|:.
  Fly   391 SNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRL------HSDRELKIMDLMQ 449

  Fly   274 IDPNQL--VMNLATFGDLNIAPHSTPSGGSVSSSHLAPPSALQPGLMRSKSDHRLATQFRQQEER 336
            ...|.:  :.:.|.||.     .:.....|:....|.|..:.|            .....:|..:
  Fly   450 SMENTMGKLQHAAQFGQ-----RAVDKANSIEFLLLKPIISAQ------------CLNLMEQTPK 497

  Fly   337 SGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRS 401
            ...|.:     .:|..:|: ...|...:.:|:      ::.|: .:.|..:.|.:.:.       
  Fly   498 CDINYQ-----LQFDSKPE-MFEQFAREMFGK------FQTDH-IDSSPKKLGMTQQL------- 542

  Fly   402 HQNDDSDSEQQQQQRQQELKERKDRVLDSEDVSRGQLSGIIRLSDCSRVVQRLADIGKEKKEKKS 466
                     |||||:||:|::::.:                    ....||:.....::::::|.
  Fly   543 ---------QQQQQQQQQLQQQQHQ--------------------HQHQVQQQQHHHQQQQQQKQ 578

  Fly   467 DAAAAAQAAVQAAIQAQKAAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATST------- 524
            .        ||...|.||..:| |||::|.|:   ..|....|   ||||..|..||.       
  Fly   579 Q--------VQHQQQQQKLQLQ-QQQQHQHNS---NNLIVGHR---GSSSVQGRLTSAVFSPISL 628

  Fly   525 -----SSGGGDTASDQRVAALKNRGGEESDGSSNQAASPVRNSAASTTRAEVSVNEANTEEEGVA 584
                 ||..|||                             ||..|......|..:.::::: :.
  Fly   629 PSSLQSSFDGDT-----------------------------NSVMSNFSMMDSPPQPSSQQQ-LP 663

  Fly   585 SESSDSEEDEEVEDEDEE---EEVDEEEEQVEESVEEEEAPRELLNLPEEALQPTSSEVTEEEES 646
            |....|::.::.:.:.:.   ::|.::::..:..|:::: .:::|:      ||||:        
  Fly   664 SAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQ-QQQVLH------QPTSA-------- 713

  Fly   647 SSEYEEVTATESEEEQEEVEGRVIEIESQDLPVINVLPPENDIAHKVEESPVDHISNQELMEETD 711
                                                                             
  Fly   714 ----------------------------------------------------------------- 713

  Fly   712 KSTDESPEEEEEEEYTEEEIESKPPVSAQVAAVKK-TQRSGSSDSSASTESSASSAAAAAVAATS 775
                                :|.|....|:.|.:. .|::|..:.:                   
  Fly   714 --------------------QSMPQQLGQLVAPQGIVQQAGHVNLN------------------- 739

  Fly   776 TSATAAAPATS-SSNSTSQNAKAPSSS--RYSTARDTTAVPEKKPFVSRFLPQHSTASTTNGSAD 837
                 |.|..: |.|........||.|  .|:.:|                    .||.|     
  Fly   740 -----AGPGPNISINGLGAGGPPPSFSMLEYNISR--------------------LASLT----- 774

  Fly   838 KKKAESSSSSEEETSSESESESEPETKAKSSATSSTTNTKSTPNSAASSTTAASSSTTSGSYRDR 902
                                |:.|:|                                       
  Fly   775 --------------------ETMPDT--------------------------------------- 780

  Fly   903 LEARRASRDDSSSTAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESEDRYGSGTGSSYT 967
                   .:|:.:...|.:.......:....||..||.   ||....|..:.:            
  Fly   781 -------LNDALAVGGGAAGPVPNVVAQVPGGSAVTGA---AVVGASHAHQQQ------------ 823

  Fly   968 SRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTGRSRYLAMKERRTRLARSRSSHQ 1032
                     |..|...|..|||.........:||                   :..|...::..:
  Fly   824 ---------SQAVMPASAVTPTQPITLADILSGD-------------------QRALNNLQALAK 860

  Fly  1033 FGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSS 1097
            .|.::.|...|  |.| |||                                             
  Fly   861 LGLNNNDFCMP--PAT-SPS--------------------------------------------- 877

  Fly  1098 GLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHAGSSTSSSAAASSSHAHGY 1162
                                                                             
  Fly   878 ----------------------------------------------------------------- 877

  Fly  1163 GSGTSGSSGRSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSPTSPTVAAAVAAAG----I 1223
                                     |:..|.:....:|...|..         .||||.|    :
  Fly   878 -------------------------LQSLNPIVGGVEDMGLNNF---------HAVAAPGTTSVV 908

  Fly  1224 TGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIF 1288
            ||.....|.|:..:       .|..|:..|.|..|.|..:|.|..|:|||::|||::|||..|..
  Fly   909 TGRNKATPMQIRCK-------FGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGAL 966

  Fly  1289 VKEFGEYGNGEGEFDCLAGVAV-NRIGQYIIADRYNH--RIQVLDPQGRFLRAFGSQGTADGKFN 1350
            ..:||..|..||:......||| :..|::::.||.|.  |:|:....|.|:|..     |....:
  Fly   967 KFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKI-----AIRYID 1026

  Fly  1351 YPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDS 1415
            ...|:...|.|.|...|..:..|.|...:|..|..| .|   ...:..|..||:.: |...|.|.
  Fly  1027 IVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF-DC---SDYMREPSDIAIRD-NDFYVCDF 1086

  Fly  1416 NNHRIQIFDVNGKVLSTVGGEGSDDGQFK---FPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFL 1477
            ..|.:.:|..:|..|..:|.|       |   ||.|:.:.:.|.:.:.||..||..:        
  Fly  1087 KGHCVAVFQDDGTFLYRIGNE-------KVTCFPNGIDISNAGDVLIGDSHGNRFHV-------- 1136

  Fly  1478 KTFGSWGSGDSEFKGLE-------GVAIMSNGNILVCDRENHRVQV 1516
            ..:...|:..|||:...       |:.|.|.|.::...:.||.|.|
  Fly  1137 ACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLV 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093 17/68 (25%)
zf-B_box 94..>122 CDD:279037 8/28 (29%)
iSH2_PI3K_IA_R 131..231 CDD:304922 23/125 (18%)
NHL_TRIM71_like 1234..1517 CDD:271324 81/296 (27%)
YncE 1253..>1517 CDD:225926 79/277 (29%)
NHL repeat 1258..1297 CDD:271324 17/38 (45%)
WD40 repeat 1261..1304 CDD:293791 18/42 (43%)
NHL repeat 1305..1344 CDD:271324 12/41 (29%)
WD40 repeat 1345..1377 CDD:293791 8/31 (26%)
NHL repeat 1352..1388 CDD:271324 10/35 (29%)
NHL repeat 1396..1436 CDD:271324 11/39 (28%)
WD40 repeat 1402..1439 CDD:293791 11/36 (31%)
NHL repeat 1445..1475 CDD:271324 8/29 (28%)
WD40 repeat 1446..1485 CDD:293791 7/38 (18%)
NHL repeat 1491..1517 CDD:271324 8/33 (24%)
mei-P26NP_001356936.1 RING_Ubox 158..230 CDD:354325 17/69 (25%)
BBOX 321..360 CDD:237988 5/42 (12%)
BBC 369..494 CDD:128778 23/147 (16%)
NHL_brat_like 913..1186 CDD:271329 83/302 (27%)
NHL repeat 936..972 CDD:271329 16/35 (46%)
NHL repeat 983..1025 CDD:271329 13/46 (28%)
NHL repeat 1028..1064 CDD:271329 10/36 (28%)
NHL repeat 1068..1107 CDD:271329 11/39 (28%)
NHL repeat 1112..1151 CDD:271329 12/46 (26%)
NHL repeat 1157..1183 CDD:271329 8/26 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45447041
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133242at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.