DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and Trim56

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_958761.1	Gene:	Trim56 / 384309	MGIID:	2685298	Length:	734	Species:	Mus musculus

Alignment Length:	526	Identity:	108/526 - (20%)
Similarity:	177/526 - (33%)	Gaps:	176/526 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFPTNVTLQ 72
            |.|.:||::...||.|||.|::|.: |:..|  .:..||:|||||....:|..||.||.||..:.
Mouse    19 LACKICLEQLHTPKTLPCLHTYCQD-CLAQL--DIGGQVRCPECREIVPVPAEGVAAFKTNFFVN 80

  Fly    73 RFLELHIEITGELP------DPT------------SGQIMERCGVCSE----------------- 102
            ..|:|   :....|      .||            .|....||..|::
Mouse    81 GLLDL---VKARAPGDVHSGKPTCALCPLVGGKSSGGPATARCLDCADDLCQACADGHRCSRQTH 142

  Fly   103 --------------------------------KAYLSHCAHCEKKICEDCK-SAHMDILRREITR 134
                                            :|....|..|.:.:|:||: ..|:|   .....
Mouse   143 KHRVVDLVGYRAGWYDEEARERQASQCPQHPGEALCFLCQPCSQLLCKDCRLGPHID---HPCLP 204

  Fly   135 FNSQIRRSLHRLQDSLAIIEKNTMSLQT--------------NAISVTEEIDEIYQRITKAIKDR 185
            ....:|.....|::.||.::.|.:.|:.              .|.||..:::|..:||.|::..:
Mouse   205 LAEAVRSRKPGLEELLAGVDSNLVELEATRVAEKEALALLREQAASVGTQVEEAAERILKSLLAQ 269

  Fly   186 SDQLKGEIDRYLAVELRNLTTLKENLDLE-ITNITSNCDTVDKYMNETVEWDDCELMDTKEIFLK 249
            ..::.|        :||.|....|....| :|.|                       :.:|...|
Mouse   270 KQEVLG--------QLRALVEAAEEATRERLTKI-----------------------ERQEQVAK 303

  Fly   250 TVEFLRHFEYENNDYSRRVRFLVSIDPNQLVMNL-----ATFGDLNIAPHSTPSGGSVSSSHLAP 309
            ...          .::|||   :|:.....:::|     .....|..||.:     |..:..:.|
Mouse   304 AAA----------AFARRV---LSLGLEAEILSLEGAITQRLRQLQDAPWT-----SGPTRCVLP 350

  Fly   310 PSALQPGLMRSKSDHRLATQFRQQEERSGYNDEPVLGGRKFGERPQRSATQANNDRYGRSGGDYD 374
            ...|.||| ..|:.|.|...|                     |.|::|...:.....|..||| :
Mouse   351 QLELHPGL-EDKNCHLLRLIF---------------------EEPKQSPKDSGKGGAGTQGGD-E 392

  Fly   375 YENDYDNEGSSGRAGKSSRFRSRFVRSHQNDDSDSEQ--QQQQRQQELKERKDRVLDSEDVSRGQ 437
            .:...|:....|:.|.:.....:..:. ||...|...  ::..|..:.|:.|.|   .:.||| :
Mouse   393 AQGQGDDRTKIGKQGGAQPLTPKEGKD-QNPQEDDGVFIERGNRPNKKKKCKGR---GKSVSR-E 452

  Fly   438 LSGIIR 443
            .|.|:|
Mouse   453 PSPILR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	19/44 (43%)
		zf-B_box	94..>122	CDD:279037	9/77 (12%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	21/114 (18%)
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
Trim56	NP_958761.1	RING_Ubox	19..60	CDD:388418	18/43 (42%)
		Bbox1_TRIM56_C-V	99..149	CDD:380868	6/49 (12%)
		Bbox_SF	165..209	CDD:381767	8/46 (17%)
		SMC_prok_B	<205..>336	CDD:274008	28/174 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..463		22/93 (24%)
		NHL	500..727	CDD:302697
		NHL repeat	531..569	CDD:271320
		WD40 repeat	540..568	CDD:293791
		NHL repeat	577..608	CDD:271320
		NHL repeat	616..653	CDD:271320
		WD40 repeat	660..699	CDD:293791
		NHL repeat	660..693	CDD:271320
		NHL repeat	702..727	CDD:271320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920