DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and Nhlrc1

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_954706.1 Gene:Nhlrc1 / 364682 RGDID:735081 Length:396 Species:Rattus norvegicus


Alignment Length:340 Identity:84/340 - (24%)
Similarity:130/340 - (38%) Gaps:69/340 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1206 LGSPTSPTVAAAVAAAGITGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGLAVGPDNS-I 1269
            |||....:.||..||:...||...            ....||.    |:...|.|||:.|... :
  Rat    90 LGSTLHASPAALSAASCAPGALTC------------YHAFGGW----GTLVNPTGLALCPKTGRV 138

  Fly  1270 VVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGR 1334
            ||......||::|||.|....:|||.|:...:......|||......::.|..:..::|.|..|:
  Rat   139 VVVHDGKRRVKIFDSGGGGAHQFGEKGDAAHDVKYPLDVAVTNDCHVVVTDAGDCSLKVFDFFGQ 203

  Fly  1335 FLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHP 1399
            .....|.|      |:.||||.......:.|.|.|...:.:.::|.. .|......|.:..|.:|
  Rat   204 IKLVVGKQ------FSLPWGVEITPHNGVLVTDAEAGTLHLLEADFP-EGVLRRIERLQAHLCNP 261

  Fly  1400 HYIAVS-NTNRVIV---------SDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFP-----RGV 1449
            ..:||| .|..:.|         |..||.|:::|:.:.:::..|...|.:   ..||     ..|
  Rat   262 RGVAVSWLTGAIAVLEHPCALGTSSGNNTRVKVFNSSMQLIGQVDSFGLN---LLFPSKITASAV 323

  Fly  1450 AVDDQGYIFVAD-SGNNRIQIFNPDGSFLKTFGSWGSGDSEFKGLE-----------GVAIMSNG 1502
            ..|.||.:.||| ||...:.:..|:               ||..|:           .:......
  Rat   324 TFDHQGNVIVADTSGPAIVCLGKPE---------------EFPALKPMVTHGLSRPVALVFTKEN 373

  Fly  1503 NILVCDRENHRVQVF 1517
            ::||.|..:|.::||
  Rat   374 SLLVLDSASHSIKVF 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 73/310 (24%)
YncE 1253..>1517 CDD:225926 71/291 (24%)
NHL repeat 1258..1297 CDD:271324 16/39 (41%)
WD40 repeat 1261..1304 CDD:293791 15/43 (35%)
NHL repeat 1305..1344 CDD:271324 9/38 (24%)
WD40 repeat 1345..1377 CDD:293791 8/31 (26%)
NHL repeat 1352..1388 CDD:271324 9/35 (26%)
NHL repeat 1396..1436 CDD:271324 13/49 (27%)
WD40 repeat 1402..1439 CDD:293791 12/46 (26%)
NHL repeat 1445..1475 CDD:271324 12/35 (34%)
WD40 repeat 1446..1485 CDD:293791 11/44 (25%)
NHL repeat 1491..1517 CDD:271324 5/36 (14%)
Nhlrc1NP_954706.1 zf-RING_5 22..70 CDD:291308
NHL 1 110..154 15/59 (25%)
NHL_TRIM32_like 115..389 CDD:271331 75/303 (25%)
NHL repeat 126..166 CDD:271331 16/39 (41%)
NHL 2 158..201 10/42 (24%)
NHL repeat 174..213 CDD:271331 9/44 (20%)
NHL 3 202..242 11/45 (24%)
NHL repeat 215..256 CDD:271331 10/41 (24%)
NHL 4 245..298 14/52 (27%)
NHL repeat 258..311 CDD:271331 14/52 (27%)
NHL 5 299..347 13/50 (26%)
NHL repeat 319..351 CDD:271331 11/46 (24%)
NHL 6 348..391 9/56 (16%)
NHL repeat 362..388 CDD:271331 4/25 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24104
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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