DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and Trim2

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_038958566.1	Gene:	Trim2 / 361970	RGDID:	1310981	Length:	809	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	218/914 - (23%)
Similarity:	342/914 - (37%)	Gaps:	220/914 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 TDESPEEEEEEEYTEEEIESKPPVSAQVAAVKK----------TQRSGSSDSSASTESSASSAAA 768
            :|.:.:...:....|.|...:|.:..:|.::..          .||:||
  Rat     2 SDPASQSYHKTLVAETEAFIRPAIKVKVGSLHSWLSQLRFNQWKQRAGS---------------- 50

  Fly   769 AAVAATSTSATAAAPATSSSNSTSQNAKAPSS----------------SRYSTARDTTAVPEKKP 817
                      ..|.|....|...|:.|..||.                .||   ::...:|....
  Rat    51 ----------RTAGPTCQWSRMASEGASIPSPVVRQIDKQFLICSICLERY---KNPKVLPCLHT 102

  Fly   818 FVSR----FLPQHS------TASTTNGSADKKKAESSSS---------SEEETSSESESESEPET 863
            |..|    ::|.||      ....|:...:|..|...::         .:....|..|..|..:|
  Rat   103 FCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDPSILQT 167

  Fly   864 KAKSSATSSTTNTKSTPNS--------AASSTTAASSSTTSGSY--------RDRLEARRASRD- 911
            ....:|....    |.||.        ..|..||.....|.|.:        :|.:|..:||..
  Rat   168 VTAVAAGKPL----SCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQV 228

  Fly   912 ------------DSS---------STAAGRSSYATPSSSGYGSGSGTTGGRTRAVPAPHHTSESE 955
                        ||:         .....::|......|.:.....|...|...:     ..|.|
  Rat   229 QLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVL-----LMELE 288

  Fly   956 DRYGSGTGSSYTSRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTGRSRYLAMKER 1020
            ..||      ...:.|.....:.:..|.|:.: .::|...|.        .:||.....|..|:.
  Rat   289 VNYG------LKHKVLQSQLDTLLQGQESIKS-CSNFTAQAL--------NHGTETEVLLVKKQM 338

  Fly  1021 RTRLARSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSS--DLSRSRSSHALKSRDN 1083
            ..:|          |:..|.|.|:.|.......::...   .|...|  :|....:::|:.|  .
  Rat   339 SEKL----------NELADQDFPLHPRENDQLDFIVET---EGLKKSIHNLGTILTTNAVAS--E 388

  Fly  1084 SPITDRGAGSSRSSGLGG----SSTTDSKDGEALSSWARYLKNKYGNKSSKDSAGSSGSARDTHA 1144
            :..|..|.   |.:.:|.    :.||..||||...:...||.   ...|:.|.:.:.|...|...
  Rat   389 TVATGEGL---RQTIIGQPMSVTITTKDKDGELCKTGNAYLT---AELSTPDGSVADGEILDNKN 447

  Fly  1145 GSSTSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSL------GLPLRQANELASSDDDGSK 1203
            |           ::...|.....|        |.:..|.|      |.|.: ...:.|:|
  Rat   448 G-----------TYEFLYTVQKEG--------DFTLSLRLYDQHIRGSPFK-LKVIRSAD----- 487

  Fly  1204 NGLGSPTSPTVAAAVAAAG---ITGAAGTIPKQVY-LRKRQQ-------LFQLGGRGSEPGSFTW 1257
               .|||:..|...|.:.|   :...|...|..:| ..||::       :|::|.:|...|.||.
  Rat   488 ---VSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTN 549

  Fly  1258 PRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRY 1322
            .:|:|......|::|||:|..||:|.::|.|...||..|...|:.....||||:..|..||||..
  Rat   550 LQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYD 614

  Fly  1323 NHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFG 1387
            |..:.:....|:|....||     ||...|.||:.|..|.|.|.|.:...|.:||.:|..|.:||
  Rat   615 NKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFG 674

  Fly  1388 SCGRGE----GQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFPRG 1448
            |.|.|:    |.|:.||:.||:::|.:|::|.:||.:::|:..|:.:...|..|..:|||..|.|
  Rat   675 SRGNGDRQFAGTLDGPHFAAVNSSNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTG 739

  Fly  1449 VAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSEFKGLEGVAIMSNGNILVCDRENHR 1513
            ||||..|.|.|||.||:|||:|:..||||....:  |.|..: |.:|:|:.|:|:::|.|..||.
  Rat   740 VAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINT--SADPLY-GPQGLALTSDGHVVVADSGNHC 801

  Fly  1514 VQVF 1517
            .:|:
  Rat   802 FKVY 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	109/294 (37%)
		YncE	1253..>1517	CDD:225926	103/267 (39%)
		NHL repeat	1258..1297	CDD:271324	14/38 (37%)
		WD40 repeat	1261..1304	CDD:293791	15/42 (36%)
		NHL repeat	1305..1344	CDD:271324	14/38 (37%)
		WD40 repeat	1345..1377	CDD:293791	11/31 (35%)
		NHL repeat	1352..1388	CDD:271324	14/35 (40%)
		NHL repeat	1396..1436	CDD:271324	13/39 (33%)
		WD40 repeat	1402..1439	CDD:293791	11/36 (31%)
		NHL repeat	1445..1475	CDD:271324	17/29 (59%)
		WD40 repeat	1446..1485	CDD:293791	21/38 (55%)
		NHL repeat	1491..1517	CDD:271324	9/25 (36%)
Trim2	XP_038958566.1	RAD18	68..>170	CDD:227719	17/104 (16%)
		RING-HC_TRIM2	81..126	CDD:319681	8/47 (17%)
		Bbox2_TRIM2_C-VII	176..217	CDD:380882	8/44 (18%)
		BBC	222..348	CDD:128778	23/155 (15%)
		IG_FLMN	386..482	CDD:214720	25/123 (20%)
		NHL_TRIM2_like	532..809	CDD:271330	107/282 (38%)
		NHL repeat	550..589	CDD:271330	14/38 (37%)
		NHL repeat	597..636	CDD:271330	15/43 (35%)
		NHL repeat	639..675	CDD:271330	14/35 (40%)
		NHL repeat	683..727	CDD:271330	14/43 (33%)
		NHL repeat	736..776	CDD:271330	22/41 (54%)
		NHL repeat	779..805	CDD:271330	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2816
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45506
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.070