DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and Trim32

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_001012103.1 Gene:Trim32 / 313264 RGDID:1305238 Length:655 Species:Rattus norvegicus


Alignment Length:575 Identity:133/575 - (23%)
Similarity:213/575 - (37%) Gaps:157/575 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   998 GTGDDSDSRYGTGRSRYLAMKERRTR--LARSRSSHQFGNDDEDLDEPVSPTTVSPSAYL----- 1055
            |...|..:||......| ..:|||.:  |||||   :|........|..:...|...:||     
  Rat   173 GVSRDLQARYKAVLQEY-GHEERRVQEELARSR---KFFTGSLAEVEKSNSQVVEEQSYLLNIAE 233

  Fly  1056 ---ASRCAYSGYGSSDLSRSRSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWA 1117
               .|||.|.      |::      :|..|.:.:.:               |.|.::.|..:|..
  Rat   234 VQAVSRCDYF------LAK------IKQADVALLEE---------------TADEEEPELTASLP 271

  Fly  1118 RYLK------NKYGNKSSKDSAGSSGSARDTHAGSSTSSSAAASSSHAHGYGSGTSGSSGRSTAS 1176
            |.|.      .|.|:........:....|..:...|.:....|:||               ::||
  Rat   272 RELTLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAVEEGAASS---------------ASAS 321

  Fly  1177 DVSRRLSLGLPLRQANELASSDDDGSKNGLGSPTS--PTVAAAVAAAGITGAAGTIPKQVYLRKR 1239
            ...|.:.:                       ||..  |:..|:.|....:.||.:|.:.::|:| 
  Rat   322 VTFREMDM-----------------------SPEEVVPSPRASPAKQRSSEAASSIQQCLFLKK- 362

  Fly  1240 QQLFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDC 1304
                 :|.:||.||.|..|..|.|...:.::|||..|:|:|||:..| |:||.....:|...| .
  Rat   363 -----MGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKG-FLKEIRRSPSGIDSF-V 420

  Fly  1305 LA------------GVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTT 1357
            |:            .||:|..|...:.|.|::.::|....|..:....||      .:.|||:|.
  Rat   421 LSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTLDGHCVACHRSQ------LSKPWGITA 479

  Fly  1358 DALGFIYVCDKENHRVQVFQSD-GSFV-----------GKFGSCGRGEGQLEHPHYIAVSNTNRV 1410
            ...|...|.|.|..::..|..| |:.|           .||.:|. .||.:.....:.::..|| 
  Rat   480 LPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCD-AEGTVYFTQGLGLNVENR- 542

  Fly  1411 IVSDSNNHRIQIFDVNGKVLSTVGGEG----------SDDGQFKFPRGVAVDDQGYIFVADSGNN 1465
                .|.|.::    .|..:.:||.:|          |::..|:...|:.||.:|.:.||||...
  Rat   543 ----QNEHHLE----GGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRK 599

  Fly  1466 RIQIFNPDGSFLKTFGSWGSGDSEFKGLE---GVAIMSNGNILVCDRENHRVQVF 1517
            .|..|...|.:.....         :||.   |:|:...|.:||.|..:|.|:::
  Rat   600 EILHFPKGGGYSVLIR---------EGLTCPVGIALTPKGQLLVLDCWDHCVKIY 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 84/319 (26%)
YncE 1253..>1517 CDD:225926 78/300 (26%)
NHL repeat 1258..1297 CDD:271324 15/38 (39%)
WD40 repeat 1261..1304 CDD:293791 16/42 (38%)
NHL repeat 1305..1344 CDD:271324 11/50 (22%)
WD40 repeat 1345..1377 CDD:293791 8/31 (26%)
NHL repeat 1352..1388 CDD:271324 14/47 (30%)
NHL repeat 1396..1436 CDD:271324 7/39 (18%)
WD40 repeat 1402..1439 CDD:293791 8/46 (17%)
NHL repeat 1445..1475 CDD:271324 10/29 (34%)
WD40 repeat 1446..1485 CDD:293791 11/38 (29%)
NHL repeat 1491..1517 CDD:271324 10/28 (36%)
Trim32NP_001012103.1 RING-HC_TRIM32_C-VII 20..66 CDD:319501
Bbox1_TRIM32_C-VII 99..139 CDD:380864
NHL_TRIM32_like 364..646 CDD:271331 82/309 (27%)
NHL repeat 376..416 CDD:271331 15/40 (38%)
NHL repeat 433..472 CDD:271331 10/44 (23%)
NHL repeat 474..514 CDD:271331 12/39 (31%)
NHL repeat 515..566 CDD:271331 13/60 (22%)
NHL repeat 579..611 CDD:271331 11/31 (35%)
NHL repeat 619..645 CDD:271331 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D489543at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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