DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and Trim25

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_033572.2 Gene:Trim25 / 217069 MGIID:102749 Length:634 Species:Mus musculus


Alignment Length:282 Identity:60/282 - (21%)
Similarity:102/282 - (36%) Gaps:80/282 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LTCCVCLDRYRIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRI----PYNGVQAFPTN 68
            |:|.|||:.::.|...||.|:|||. |::..........:||:||..:::    ..|.|..    
Mouse    11 LSCSVCLELFKEPVTTPCGHNFCMS-CLDETWVVQGPPYRCPQCRKVYQVRPQLQKNTVMC---- 70

  Fly    69 VTLQRFLELHIEIT--GELPDP-----TSGQIMERCGVCSEKAYLSHCAHCEKKICEDCKSAHM- 125
            ..:::||:.....|  .:...|     :|......|..|..:..:..|..|....|::....|. 
Mouse    71 AVVEQFLQAEQARTPVDDWTPPARFSASSAATQVACDHCLTEIAVKTCLVCMASFCQEHLRPHFD 135

  Fly   126 --------------DILRREITRFN------------------------------SQIRRSL-HR 145
                          |:|||:.|:.|                              ||....| ::
Mouse   136 SPAFQDHPLQSPIRDLLRRKCTQHNRLRELFCPEHGECICHICLVEHKTCSPTTLSQASADLEYK 200

  Fly   146 LQDSLAIIEKNTMSLQTNAISVTEEIDEIYQRITKAIKDRSDQLKGE-------IDRYLAVELRN 203
            |::.|.|:..:.    ..|....|::....|.:..::|.:.:||:.|       ||   |.|..:
Mouse   201 LRNKLTIMHSHI----NGATKALEDVRSKQQCVQDSMKRKMEQLRQEYMEMKAVID---AAETSS 258

  Fly   204 LTTLKENLDLEITNITSNCDTV 225
            |..|||    |...:....||:
Mouse   259 LRKLKE----EEKRVYGKFDTI 276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093 16/44 (36%)
zf-B_box 94..>122 CDD:279037 5/27 (19%)
iSH2_PI3K_IA_R 131..231 CDD:304922 26/133 (20%)
NHL_TRIM71_like 1234..1517 CDD:271324
YncE 1253..>1517 CDD:225926
NHL repeat 1258..1297 CDD:271324
WD40 repeat 1261..1304 CDD:293791
NHL repeat 1305..1344 CDD:271324
WD40 repeat 1345..1377 CDD:293791
NHL repeat 1352..1388 CDD:271324
NHL repeat 1396..1436 CDD:271324
WD40 repeat 1402..1439 CDD:293791
NHL repeat 1445..1475 CDD:271324
WD40 repeat 1446..1485 CDD:293791
NHL repeat 1491..1517 CDD:271324
Trim25NP_033572.2 RING 13..53 CDD:302633 14/40 (35%)
PspA 229..>360 CDD:224755 15/55 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..437
SPRY_PRY_TRIM25 464..632 CDD:293971
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2677
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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