DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and Nhlrc3

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_766089.1 Gene:Nhlrc3 / 212114 MGIID:2444520 Length:347 Species:Mus musculus


Alignment Length:354 Identity:97/354 - (27%)
Similarity:146/354 - (41%) Gaps:72/354 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1172 RSTASDVSRRLSLGLPLRQANELASSDDDGSKNGLGSP------TSPTVAAAVAAAG----ITGA 1226
            |...|.|||..|..:..|..:.|...|       ||.|      |..|...||.:..    :...
Mouse    23 RFCGSLVSRTFSFHVSWRMEDPLFRLD-------LGWPKNSEYFTGATFCVAVDSLNGLVYVAQR 80

  Fly  1227 AGTIPKQVYLRKRQQLFQLGGRGSEPGSF--TW------PRGLAVGP---DNSIVVADSSN---- 1276
            ...|||.:..             ||.|.|  .|      |.|:.|..   :.|:.:.|..:    
Mouse    81 GDNIPKVLVF-------------SEDGYFLRAWNYTVDTPHGMFVSGTPFEQSVWITDVGSGPYG 132

  Fly  1277 HRVQVFDSNGIFVKEFGEYG-NGEG----EFDCLAGVAVNRIGQYIIAD---RYNHRIQVLDPQG 1333
            |.|:.::|.|..|:..|..| .|.|    :||..|.:.|:..|:..|.|   ..|:|:..|....
Mouse   133 HTVKKYNSLGDLVQVLGTPGKKGTGLNPLQFDNPAELYVDDTGEMYIVDGDGGLNNRLVKLSQDF 197

  Fly  1334 RFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSD-GSFVGKFGSCGRGEGQLE 1397
            ..|...|..||...|||.|..||.||:|.::|.|:.|.|:|||..| |.::|.:.:|...||   
Mouse   198 MILWLRGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTGEWLGAWDNCFTEEG--- 259

  Fly  1398 HPHYIAVSNTNR-VIVSDSNNHRIQIF--DVNG-----KVLSTVGGEGSDDGQFKFPRGVAVDDQ 1454
             |..:..:...: :||:..|..|:.:.  ..:|     .|:||:  :.:|.   ..|..:.||.:
Mouse   260 -PSAVRFTPDGKYLIVAQLNLSRLSVLLAPPSGSIGDCSVVSTI--QLADQ---VLPHLLEVDRK 318

  Fly  1455 -GYIFVADSGNNRIQIFNPDGSFLKTFGS 1482
             |.::||:.|..:||.:.|..|....||:
Mouse   319 TGAVYVAEIGAKQIQKYIPWHSRTPAFGA 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 78/282 (28%)
YncE 1253..>1517 CDD:225926 76/263 (29%)
NHL repeat 1258..1297 CDD:271324 12/46 (26%)
WD40 repeat 1261..1304 CDD:293791 13/54 (24%)
NHL repeat 1305..1344 CDD:271324 10/41 (24%)
WD40 repeat 1345..1377 CDD:293791 15/31 (48%)
NHL repeat 1352..1388 CDD:271324 16/36 (44%)
NHL repeat 1396..1436 CDD:271324 9/47 (19%)
WD40 repeat 1402..1439 CDD:293791 8/44 (18%)
NHL repeat 1445..1475 CDD:271324 10/30 (33%)
WD40 repeat 1446..1485 CDD:293791 13/38 (34%)
NHL repeat 1491..1517 CDD:271324
Nhlrc3NP_766089.1 NHL 1 47..93 12/65 (18%)
NHL 66..336 CDD:302697 79/291 (27%)
YncE <66..308 CDD:225926 70/263 (27%)
NHL repeat 107..153 CDD:271320 11/45 (24%)
NHL 2 150..196 13/45 (29%)
NHL repeat 166..205 CDD:271320 9/38 (24%)
NHL 3 200..243 20/42 (48%)
NHL repeat 213..250 CDD:271320 17/36 (47%)
NHL repeat 258..299 CDD:271320 8/44 (18%)
NHL 4 294..338 13/48 (27%)
NHL repeat 308..335 CDD:271320 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D489543at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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