DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and F40G9.12

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_497167.2	Gene:	F40G9.12 / 185559	WormBaseID:	WBGene00018247	Length:	190	Species:	Caenorhabditis elegans

Alignment Length:	157	Identity:	48/157 - (30%)
Similarity:	66/157 - (42%)	Gaps:	42/157 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CCVCLDRY-----RIPKLLPCQHSFCMEPCMEGLVDYVRRQV--KCPECRA------EHRI--PY 59
            |.:|...|     ..|::|.|.|::| |.|::.|.. :|..|  .||.|..      :|.|  .:
Worm    29 CKICYKNYETSGDHCPRVLSCGHTYC-EICIQELAS-LRNNVVIACPYCTKLSIISFKHWILTSF 91

  Fly    60 NGVQAFPTNVTLQRFLELHIEITGELPDPTSGQIMERCGVC-----SEKAYLSHCAHCEKKICED 119
            ....|||||     ||.|.| :.|:..|      |.:||||     |::....| ..|.|.:|||
Worm    92 RVSSAFPTN-----FLVLEI-LNGKAKD------MLQCGVCQLTYSSQRIPRIH-PSCGKSVCED 143

  Fly   120 CKSAHMDILRREITRFNSQIRRSLHRL 146
            ||       ..|.........:||:||
Worm   144 CK-------EHECKACEPPNEQSLYRL 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	16/56 (29%)
		zf-B_box	94..>122	CDD:279037	13/32 (41%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	5/16 (31%)
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
F40G9.12	NP_497167.2	RING_Ubox	28..75	CDD:388418	15/47 (32%)
F40G9.12	NP_497167.2	RING-HC finger (C3HC4-type)	29..75	CDD:319361	15/47 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920