DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and nhl-2

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_498026.1 Gene:nhl-2 / 175654 WormBaseID:WBGene00003598 Length:1032 Species:Caenorhabditis elegans


Alignment Length:1324 Identity:242/1324 - (18%)
Similarity:411/1324 - (31%) Gaps:473/1324 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 RKFGERPQRSATQANNDRYGRSGGDYDYENDYDNEGSSGRAGKSSRFRSRFVRSHQND------- 405
            :|..:||    |.|.|   ||........|:..|.|:....|:..      :||..:.       
 Worm     2 KKAADRP----TSAVN---GRHESPATSTNNTQNSGTPSLNGQDP------LRSTSSSPLFGTEP 53

  Fly   406 -DSDSEQQQQQRQQELKERKDRVLD-----SEDVSRGQLS------------------------- 439
             ..|........||:.  ||.||||     .||....||.                         
 Worm    54 LPEDDHASCPYCQQDF--RKPRVLDCLHSMCEDCIIAQLDGHLQAKSAAIEEKKRATAAMLDCEL 116

  Fly   440 ------------GIIRLSDCS---------RVVQ-------RLADIGKEKKE-------KKSDAA 469
                        |:||...||         |.|.       |||::.:.:.|       |...|.
 Worm   117 ETPKVKERPTPPGVIRCPICSQESHVGNDVRYVHAMLLDFVRLAEMKEVEVEKMVAHHRKPCTAC 181

  Fly   470 AAAQAAVQAAIQAQK----------AAMQRQQQKNQQNAADEEELARQKRKNAGSSSTGGAATST 524
            .:.|.|:....|...          ..|...|.......||..:............||.......
 Worm   182 KSEQEAIAFCDQCSSDLCENCTTAHTVMNLFQGHTVTTFADLRQPGAHPELRQVMCSTHNQHMRY 246

  Fly   525 SSGGGDTASDQRVAALKNRGGEESDGSSNQAASPVRNSAASTT-RAEVSVNEANTEEEGVASESS 588
            .....:||:.::...:.:...:..| .:....:.:|....||. |.|...|.:..:...:..:|.
 Worm   247 LCAACETAACKQCLEVDHLNHKIID-INELVINAIREDVTSTVDRVEKKYNNSVADMNSLPDKSQ 310

  Fly   589 DSEEDEEVEDEDEEEEVDEEEEQVEESVEEEEAPRELLNLPEEALQPTSSEVTEEEESSSEYEEV 653
            ...|..|:    .:..||:..|::..|:  |||.::.:|..|||      .:.:|......|.:.
 Worm   311 QLNEQYEI----AKYRVDKHYEELRNSI--EEAYQKSVNDLEEA------RIRQESNIDEMYRKS 363

  Fly   654 TATESE-------EEQEEVEGRVIEIESQDLPVI-------NVLPPENDIAHKVE-------ESP 697
            ...|:.       ..:...:|..:|:......||       :.:|..   .|:||       :..
 Worm   364 QVNEARVHDAINFTRRLLTKGNGLELVVSRKKVIQQFGNLSHAIPSH---GHQVELEFYTPSKKQ 425

  Fly   698 VDHISNQ-------ELMEETDKSTDESPEEEEEEEYTEEEIESKPPVSAQVAAVKKTQRSGSSDS 755
            :||..:|       .:::.|.|...                      :|..|:..:::|.||...
 Worm   426 IDHFVHQLTGTVIGRVIQPTVKDVG----------------------NATAASTDRSERGGSQPG 468

  Fly   756 SASTESSASSAAAAAVAATSTSATAAAPATSSSNSTSQNAKAPSSSRYSTARDTTAVPEKKPFVS 820
            .                  ..|::||.|:..........::.|........|       ||    
 Worm   469 G------------------GRSSSAANPSQQDEWGRPVYSQNPQLGAIGGER-------KK---- 504

  Fly   821 RFLPQHSTASTTNGSADKKKA----ESSSSSEEETSSESESESEPETKAKSSATSSTTNT----- 876
                  :|.:.|||:.....|    ..||...|.|:      ..|.|..::..|.:.|.|     
 Worm   505 ------NTQNGTNGTRGDSNAFGGWPPSSHPPESTT------PPPVTGPQTMITGAPTQTAAPIV 557

  Fly   877 -----KSTPNSAASSTTAASSSTTSGSYRDRLEARRASRDDSSSTAAGRSSYATPSSSGYGSGSG 936
                 .:.||:||.:..||                 ..|.|..:.||.....|..:       :|
 Worm   558 SQQQLSNLPNAAAMAAAAA-----------------GMRPDLVALAANHMDLAALT-------NG 598

  Fly   937 TTGGRTRAVPAPHHTSESEDRYGSGTGSSYTSRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGD 1001
            :|.|....:|.....:....|.|                      .|:::|||      .||...
 Worm   599 STNGSQTPLPESIFPAMWNARQG----------------------LPAVATPT------TTGLST 635

  Fly  1002 DSDSRYGTGRSRYLAMKERRTRLARSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGS 1066
            ::.       :.|:..|....:| ::.:||:           ::|..:|                
 Worm   636 NAS-------AAYMQQKLAAAQL-QALASHR-----------LNPQIMS---------------- 665

  Fly  1067 SDLSRSRSSHALKSRDNSPITDRGAGSSRSSGLGGSSTTDSKDGEALSSWARYLKNKYGNKSSKD 1131
              ::..|::..::                               |.|:      .|..||.|...
 Worm   666 --MNNLRTNQTIQ-------------------------------EFLA------MNAMGNLSLNP 691

  Fly  1132 SAGSSGSARDTHAGSSTSSSAAASSSHAHGYGSGTSGSSGRSTASDVSRRLSLGLPLRQANELAS 1196
            ..              ||::|||.::.|      .:.|:..:|||||      |.....||....
 Worm   692 QL--------------TSAAAAALAATA------AANSAVTTTASDV------GQSQNSANAQRV 730

  Fly  1197 SDDDGSKNGLGSPTSPTVAAAVAAAGITGAAGTIPKQVYLRKRQQLFQLGGRGSEPGSFTWPRGL 1261
            ||                                      .|...:|....:||.......|.|.
 Worm   731 SD--------------------------------------LKVHSVFGTSQQGSTIRELHCPSGF 757

  Fly  1262 AVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDC-------LAGVAVNRIGQYIIA 1319
            .:...:.|::||::||||.|......:  :.|..|..:|:. |       |.|.||    :|::.
 Worm   758 CLSDTDDILIADTNNHRVVVCGPPHPW--KIGRPGTDDGQL-CFPRKVIALRGEAV----RYVVL 815

  Fly  1320 DRYNH---RIQVLDPQGRFLRAF--------------GSQGTADGKFNYPWGVTTDALGFIYVCD 1367
            |:...   |.|:.:.:|.|::..              .:..|.:|:.     :..|..||:|..|
 Worm   816 DKGGDGKTRAQIFEARGEFVKRLNMMALVPRGGIEVSAAAATPNGQL-----LLVDTAGFVYSID 875

  Fly  1368 KENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLST 1432
            .:..|| .|..|.|            .||.....:|:.: |.:.::|..:|.:|::...||.:..
 Worm   876 VDAPRV-TFWFDAS------------TQLGEASDVAMFD-NLIYITDFKHHCVQVYTSEGKFIRK 926

  Fly  1433 VGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQ--IFNPDGSFLKTFGSWGSGDSEFK--GL 1493
            :|    :..|..:|.|:.|...|.:.|||:..|.:.  :|:|:|..:.:|     ..:||:  ..
 Worm   927 MG----EPSQTPYPIGIDVSKAGEVLVADTHGNHLHVVVFSPEGQHIHSF-----THNEFRLSRC 982

  Fly  1494 EGVAIMSNGNILVCDRENHRVQVF 1517
            .|:.|..:|:|:...:.||.:.||
 Worm   983 VGLRIAKSGHIVTLCKHNHTLFVF 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 71/310 (23%)
YncE 1253..>1517 CDD:225926 67/291 (23%)
NHL repeat 1258..1297 CDD:271324 11/38 (29%)
WD40 repeat 1261..1304 CDD:293791 11/42 (26%)
NHL repeat 1305..1344 CDD:271324 10/55 (18%)
WD40 repeat 1345..1377 CDD:293791 8/31 (26%)
NHL repeat 1352..1388 CDD:271324 10/35 (29%)
NHL repeat 1396..1436 CDD:271324 9/39 (23%)
WD40 repeat 1402..1439 CDD:293791 8/36 (22%)
NHL repeat 1445..1475 CDD:271324 10/31 (32%)
WD40 repeat 1446..1485 CDD:293791 12/40 (30%)
NHL repeat 1491..1517 CDD:271324 6/27 (22%)
nhl-2NP_498026.1 RING 62..>86 CDD:214546 10/25 (40%)
BBOX 173..217 CDD:197662 7/43 (16%)
BBOX 233..272 CDD:197662 5/39 (13%)
BBC 280..406 CDD:128778 27/137 (20%)
NHL_brat_like 729..1009 CDD:271329 75/351 (21%)
NHL repeat 754..788 CDD:271329 10/35 (29%)
NHL repeat 799..843 CDD:271329 10/47 (21%)
NHL repeat 846..887 CDD:271329 10/46 (22%)
NHL repeat 891..930 CDD:271329 9/43 (21%)
NHL repeat 935..974 CDD:271329 12/43 (28%)
NHL repeat 980..1006 CDD:271329 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133242at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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