DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and F43C11.8

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_494244.2	Gene:	F43C11.8 / 173590	WormBaseID:	WBGene00018385	Length:	323	Species:	Caenorhabditis elegans

Alignment Length:	294	Identity:	62/294 - (21%)
Similarity:	104/294 - (35%)	Gaps:	67/294 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTCCVCLDRY------RIPKLLPCQHSFCMEPCMEGLVDYVRRQVKCPECRAEHRIPYNGVQAFP 66
            :.|.:|.:.:      .||::|.|.|:.| ..|.|.|:.  ...:.||.||....:  :.|:...
Worm     4 IECEICNEDFSSATDENIPRILRCGHTIC-HGCAEKLLQ--NSMILCPFCREATNV--STVKDLQ 63

  Fly    67 TNVTLQRFLELHIEITGELPDPTSGQIMERCG---------VCSEKAYLSHCAHCEKKICEDCK- 121
            .|..|.:.:| |.:...|..||....  .:|.         ||.|..    |:..:|.:|..|:
Worm    64 KNFALLQAVE-HAKTRTEEKDPIDSP--PKCASHQYNFAEFVCIEPT----CSSSDKLMCRTCEE 121

  Fly   122 -SAH----MDILRREITRFNSQIRRSLHRLQDSLAIIEKNTMSLQTNAI---------------- 165
             .||    ..:|:.|..:....:...|.|.:|..:.|:.|...:.|..:
Worm   122 FGAHAGHNRGLLQSEAAKLRQFLSGKLSRSEDLASKIDANIEKIGTAQLTNLDDGEVFQEKKVSI 186

  Fly   166 -----SVTEEIDEI-------YQRITKAIKDRSDQLKGEIDRYLAVELRNLTTLK-----ENLDL 213
                 |:.|.:|.:       .|.|.:.....:|.|..|:...|..:.|....||     .|.||
Worm   187 IAFYASIRETLDALENDALATLQNIAETNFFTNDLLIAELSESLNRQKRKSAELKLFMKMSNADL 251

  Fly   214 EITNITSNCDTVDKYMNETVEWDDCELMDTKEIF 247
            ...|......:.::...|..:.:. |:.|...||
Worm   252 LAVNSALEVSSENELWTEFADVEP-EVFDAALIF 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	15/50 (30%)
		zf-B_box	94..>122	CDD:279037	8/38 (21%)
		iSH2_PI3K_IA_R	131..231	CDD:304922	23/132 (17%)
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
F43C11.8	NP_494244.2	RING_Ubox	5..52	CDD:388418	14/49 (29%)
		modified RING-HC finger (C3HC3D-type)	6..50	CDD:319361	13/46 (28%)
		Bbox2_TRIM23_C-IX_rpt2	88..137	CDD:380832	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920