DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tn and TRIM3

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001234935.1	Gene:	TRIM3 / 10612	HGNCID:	10064	Length:	744	Species:	Homo sapiens

Alignment Length:	448	Identity:	143/448 - (31%)
Similarity:	211/448 - (47%)	Gaps:	58/448 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 LGGSSTTDSKDGEALSSWARYLKNKYGNKSS-----KDSAG---SSGSA--RDTHAGSSTSSSAA 1153
            ||...||.:...|.:::.....:...|..:|     ||..|   .:|||  |....|...:....
Human   312 LGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPV 376

  Fly  1154 ASSSHAHG-----YGSGTSGSSGRSTASDVSRRLSLGLPLR---------QANELASSDDDGSKN 1204
            ....|.:|     |.:.|.|....|.       |..|.|:|         :..:|..|.|| .|.
Human   377 PVVDHKNGTYELVYTARTEGELLLSV-------LLYGQPVRGSPFRVRALRPGDLPPSPDD-VKR 433

  Fly  1205 GLGSPTSPTVAAAVAAAGITGAAGTIPKQVYLR--KRQQ-------LFQLGGRGSEPGSFTWPRG 1260
            .:.||..|       .:.:...|...|..:|..  ||:.       :|::|.||.|.|.||..:|
Human   434 RVKSPGGP-------GSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQG 491

  Fly  1261 LAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFDCLAGVAVNRIGQYIIADRYNHR 1325
            ::......||||||:|..:|||.:.|.|...||..|...|:.....||||:..|..|:||..|..
Human   492 VSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRW 556

  Fly  1326 IQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDKENHRVQVFQSDGSFVGKFGSCG 1390
            :.:..|:|:|....|:     |:...|.||..|..|.|.|.|.::..|..||.:|..||:||..|
Human   557 VSIFSPEGKFKTKIGA-----GRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRG 616

  Fly  1391 RGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNGKVLSTVGGEGSDDGQFKFPRGVAVDDQG 1455
            ..:.....||::||:|.|.::|:|.:||.::::..:|:.|...|..|..:|||..|.|||||..|
Human   617 ATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNG 681

  Fly  1456 YIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSE-FKGLEGVAIMSNGNILVCDRENH 1512
            .|.|||.||:|||:|:..||||    |:.:..:| ..|.:|:|:.|:|:::|.|..||
Human   682 NIIVADWGNSRIQVFDSSGSFL----SYINTSAEPLYGPQGLALTSDGHVVVADAGNH 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	108/289 (37%)
		YncE	1253..>1517	CDD:225926	100/261 (38%)
		NHL repeat	1258..1297	CDD:271324	15/38 (39%)
		WD40 repeat	1261..1304	CDD:293791	16/42 (38%)
		NHL repeat	1305..1344	CDD:271324	13/38 (34%)
		WD40 repeat	1345..1377	CDD:293791	10/31 (32%)
		NHL repeat	1352..1388	CDD:271324	15/35 (43%)
		NHL repeat	1396..1436	CDD:271324	13/39 (33%)
		WD40 repeat	1402..1439	CDD:293791	12/36 (33%)
		NHL repeat	1445..1475	CDD:271324	17/29 (59%)
		WD40 repeat	1446..1485	CDD:293791	22/38 (58%)
		NHL repeat	1491..1517	CDD:271324	9/22 (41%)
TRIM3	NP_001234935.1	Interaction with KIF21B. /evidence=ECO:0000250\|UniProtKB:Q9R1R2	2..290
		RING-HC_TRIM3	19..63	CDD:319682
		RING-HC finger (C3HC4-type)	22..62	CDD:319682
		BBOX	110..151	CDD:197662
		BBC	158..284	CDD:128778
		Filamin	317..418		23/107 (21%)
		IG_FLMN	322..419	CDD:214720	21/103 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..464		12/52 (23%)
		NHL_TRIM2_like	471..744	CDD:271330	105/274 (38%)
		NHL 1	473..516		19/42 (45%)
		NHL repeat	489..528	CDD:271330	15/38 (39%)
		NHL 2	520..563		13/42 (31%)
		NHL repeat	536..575	CDD:271330	14/43 (33%)
		NHL 3	564..605		15/45 (33%)
		NHL repeat	578..615	CDD:271330	16/36 (44%)
		NHL 4	609..652		15/42 (36%)
		NHL repeat	622..663	CDD:271330	13/40 (33%)
		NHL 5	656..699		23/42 (55%)
		NHL repeat	669..711	CDD:271330	23/45 (51%)
		NHL 6	700..743		15/40 (38%)
		NHL repeat	714..740	CDD:271330	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2896
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41389
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	1	1.000	-	-		X1654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.100