DRSC/TRiP Functional Genomics Resources

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Protein Alignment tn and Nhlrc1

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_780549.1 Gene:Nhlrc1 / 105193 MGIID:2145264 Length:401 Species:Mus musculus


Alignment Length:306 Identity:76/306 - (24%)
Similarity:119/306 - (38%) Gaps:65/306 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1252 PGSFT-------W-----PRGLAVGPDNS-IVVADSSNHRVQVFDSNGIFVKEFGEYGNGEGEFD 1303
            ||:.|       |     |.|||:.|... :||......||::|||.|....:|||.|:...:..
Mouse   113 PGTLTCYHAFGGWGTLVNPTGLALCPKTGRVVVVHDGKRRVKIFDSGGGGAHQFGEKGDAAHDVK 177

  Fly  1304 CLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCDK 1368
            ....|||......::.|..:..::|.|..|:.....|.|      |:.||||.......:.|.|.
Mouse   178 YPLDVAVTNDCHVVVTDAGDCSLKVFDFFGQIKLVVGKQ------FSLPWGVEITPHNGVLVTDA 236

  Fly  1369 ENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVS-NTNRVIV---------SDSNNHRIQIF 1423
            |...:.:.::|.. .|......|.:..|..|..:||| .|..:.|         :..||.|:::|
Mouse   237 EAGTLHLLEADFP-EGVLRRIERLQAHLCSPRGLAVSWLTGAIAVLEHPCAFGRTGCNNTRVKVF 300

  Fly  1424 DVNGKVLSTVGGEGSDDGQFKFP-----RGVAVDDQGYIFVAD-SGNNRIQIFNPDGSFLKTFGS 1482
            :...:::..|...|.:   ..||     ..|..|.||.:.||| ||...:.:..|:         
Mouse   301 NSTMQLIGQVDSFGLN---LLFPSKVTASAVTFDHQGNVIVADTSGPAIVCLGKPE--------- 353

  Fly  1483 WGSGDSEFKGLE-----------GVAIMSNGNILVCDRENHRVQVF 1517
                  ||..|:           .:|.....::||.|..:|.::||
Mouse   354 ------EFPALKPIITHGLSRPVALAFTKENSLLVLDTASHSIKVF 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 74/304 (24%)
YncE 1253..>1517 CDD:225926 73/303 (24%)
NHL repeat 1258..1297 CDD:271324 16/39 (41%)
WD40 repeat 1261..1304 CDD:293791 15/43 (35%)
NHL repeat 1305..1344 CDD:271324 9/38 (24%)
WD40 repeat 1345..1377 CDD:293791 8/31 (26%)
NHL repeat 1352..1388 CDD:271324 9/35 (26%)
NHL repeat 1396..1436 CDD:271324 12/49 (24%)
WD40 repeat 1402..1439 CDD:293791 11/46 (24%)
NHL repeat 1445..1475 CDD:271324 12/35 (34%)
WD40 repeat 1446..1485 CDD:293791 11/44 (25%)
NHL repeat 1491..1517 CDD:271324 6/36 (17%)
Nhlrc1NP_780549.1 zf-RING_5 27..75 CDD:291308
NHL 1 115..159 13/43 (30%)
NHL_TRIM32_like 120..394 CDD:271331 73/299 (24%)
NHL repeat 131..171 CDD:271331 16/39 (41%)
NHL 2 163..206 10/42 (24%)
NHL repeat 179..218 CDD:271331 9/44 (20%)
NHL 3 207..247 11/45 (24%)
NHL repeat 220..261 CDD:271331 10/41 (24%)
NHL 4 250..303 13/52 (25%)
NHL repeat 263..316 CDD:271331 13/52 (25%)
NHL 5 304..352 13/50 (26%)
NHL repeat 324..356 CDD:271331 11/46 (24%)
NHL 6 353..396 10/56 (18%)
NHL repeat 367..393 CDD:271331 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24104
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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