DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and si:dkey-106l3.6

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_003199368.2	Gene:	si:dkey-106l3.6 / 100526811	ZFINID:	ZDB-GENE-091204-159	Length:	261	Species:	Danio rerio

Alignment Length:	126	Identity:	30/126 - (23%)
Similarity:	52/126 - (41%)	Gaps:	26/126 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTCCVCLDRYRI----PKLLPCQHSFCMEPCMEGLVDYVRRQ--VKCPECRAEHRI--PYNGVQA 64
            |.|..|...|..    |::|.|.||.| |.|::.|.:...:.  :.||.||.|..:  .| |:.|
Zfish   144 LDCPTCGHTYNFAGKRPRILSCLHSVC-EECLQILYESCPKYKFISCPTCRRETVLFTDY-GLAA 206

  Fly    65 FPTNVTLQRFLELHIEITGELPDPTSGQIMERCGVCSEKAYLSHCAHCEKKICEDCKSAHM 125
                      |.::..|...||...:|.:  :.|...:::    |....::.|:...:.|:
Zfish   207 ----------LAINTSILSRLPPDPAGTV--QWGSDGDRS----CYQTVRQYCQSACTCHI 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093	16/50 (32%)
		zf-B_box	94..>122	CDD:279037	3/27 (11%)
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324
		YncE	1253..>1517	CDD:225926
		NHL repeat	1258..1297	CDD:271324
		WD40 repeat	1261..1304	CDD:293791
		NHL repeat	1305..1344	CDD:271324
		WD40 repeat	1345..1377	CDD:293791
		NHL repeat	1352..1388	CDD:271324
		NHL repeat	1396..1436	CDD:271324
		WD40 repeat	1402..1439	CDD:293791
		NHL repeat	1445..1475	CDD:271324
		WD40 repeat	1446..1485	CDD:293791
		NHL repeat	1491..1517	CDD:271324
si:dkey-106l3.6	XP_003199368.2	RING-HC_RNF208	143..196	CDD:319473	17/52 (33%)
si:dkey-106l3.6	XP_003199368.2	RING-HC finger (C3HC4-type)	146..192	CDD:319473	14/46 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920