DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tn and nhlrc3

DIOPT Version :9

Sequence 1:	NP_001137707.1	Gene:	tn / 37190	FlyBaseID:	FBgn0265356	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_002936773.2	Gene:	nhlrc3 / 100497010	XenbaseID:	XB-GENE-988782	Length:	344	Species:	Xenopus tropicalis

Alignment Length:	257	Identity:	67/257 - (26%)
Similarity:	102/257 - (39%)	Gaps:	75/257 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1257 WPR----------GLAVGPDNSIV-VADSSNH--RVQVFDSNGIFVKEFG------EYGNGEGEF 1302
            ||:          |:||.|.||:| ||....:  :|.||...|.|.:::.      .:|......
Frog    55 WPKNADYFTGVTFGVAVDPTNSLVYVAQRGENVSKVLVFTEEGYFKQQWNTDSIDMPHGIFAVST 119

  Fly  1303 DCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGFIYVCD 1367
            |....:.:..:||    ..:.|.::...|.|:.|:..|:.|.:        |...|.|
Frog   120 DKEHSIWITDVGQ----GNFGHTVKKYSPSGKLLQVLGTAGKS--------GSALDPL------- 165

  Fly  1368 KENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSN---NHRIQIFDVNGKV 1429
                                       |.:.|..|.|.|:..:.:.|.:   |:||..|..:..:
Frog   166 ---------------------------QFDQPAEIFVENSGDLYIVDGDGGLNNRILKFTKDFWL 203

  Fly  1430 LSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSW-GSGDSEF 1490
            |.|:||.|:..|||..|..|.||:.|.::|||.||.|:|.|:      ||.|.| |:..|.|
Frog   204 LWTLGGRGTKPGQFFIPHSVTVDEVGRVWVADRGNKRMQAFD------KTSGEWIGTWSSCF 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tn	NP_001137707.1	RING	9..54	CDD:238093
		zf-B_box	94..>122	CDD:279037
		iSH2_PI3K_IA_R	131..231	CDD:304922
		NHL_TRIM71_like	1234..1517	CDD:271324	67/257 (26%)
		YncE	1253..>1517	CDD:225926	67/257 (26%)
		NHL repeat	1258..1297	CDD:271324	15/57 (26%)
		WD40 repeat	1261..1304	CDD:293791	14/51 (27%)
		NHL repeat	1305..1344	CDD:271324	7/38 (18%)
		WD40 repeat	1345..1377	CDD:293791	3/31 (10%)
		NHL repeat	1352..1388	CDD:271324	3/35 (9%)
		NHL repeat	1396..1436	CDD:271324	12/42 (29%)
		WD40 repeat	1402..1439	CDD:293791	13/39 (33%)
		NHL repeat	1445..1475	CDD:271324	13/29 (45%)
		WD40 repeat	1446..1485	CDD:293791	17/39 (44%)
		NHL repeat	1491..1517	CDD:271324	67/257 (26%)
nhlrc3	XP_002936773.2	NHL	52..340	CDD:302697	67/257 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010