DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tn and trim2a

DIOPT Version :9

Sequence 1:NP_001137707.1 Gene:tn / 37190 FlyBaseID:FBgn0265356 Length:1517 Species:Drosophila melanogaster
Sequence 2:NP_001014393.1 Gene:trim2a / 100003782 ZFINID:ZDB-GENE-050327-99 Length:744 Species:Danio rerio


Alignment Length:805 Identity:210/805 - (26%)
Similarity:311/805 - (38%) Gaps:192/805 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   793 QNAKAPSSSRYS--TARDTTAVPEK--KPFVSRFLPQHSTASTTNGSADKKKAESSSSSEEETSS 853
            ||...|.|...|  ..|.|:.:|||  ....|.|.       .||.....||:.:|:.||:.|.:
Zfish    48 QNYIPPHSLTLSCPVCRQTSILPEKGVAALQSNFF-------ITNLMEVLKKSPNSNLSEDYTDA 105

  Fly   854 ESESESEPETKAKSSATSSTTNTKSTPNSAAS--------STTAASSSTTSGSY--------RDR 902
            .:              ..:|....|.||...:        ..||.....|||.:        :|.
Zfish   106 IN--------------GVATGQPLSCPNHGGNVMEFYCPPCETAMCEECTSGEHAEHATVPLKDV 156

  Fly   903 LEARRASRDDSSSTAAGR----------------------SSYATPSSSGYGSGSGTTGGRTRAV 945
            ||..:||..:.......|                      ||......:.:.....|...|...:
Zfish   157 LEQHKASLQEQLDAVKNRLPEIESALEVLSEILQQLSSQKSSIEEMIHATFEELQKTLNVRKSVL 221

  Fly   946 PAPHHTSESEDRYGSGTGSSYTSRFLNKSKSSAIVTQPSLSTPTASFDEDATGTGDDSDSRYGTG 1010
                 ..|.|..||      ...:.|.....|.:..|..:.: :.||.|.|...|.:::      
Zfish   222 -----LMELEVNYG------LKQKVLQTQLESLLQGQDGIRS-SCSFTEQALNHGSEAE------ 268

  Fly  1011 RSRYLAMKERRTRLARSRSSHQFGNDDEDLDEPVSPTTVSPSAYLASRCAYSGYGSSDLSRSRSS 1075
               .|.:|::.:               |.|||            ||::                .
Zfish   269 ---VLLVKKQMS---------------ERLDE------------LANQ----------------E 287

  Fly  1076 HALKSRDNSPI-----TDRGAGSSRS-SGLGGSSTTDSKDGEALSSWARYLKNKYGNKSS----- 1129
            ..|:..:|:.:     ||   |..:| ..||...||::...|.:::.........|..:|     
Zfish   288 LPLRPEENNQLDFLVETD---GLRKSIHNLGAIVTTNAVAAETVATGEGLRHCIVGQLTSVTVTT 349

  Fly  1130 KDSAGSSGSARDTHAGSSTSSSAAASSSHAHG----YGSGT------SGSSGRSTASDVSRRLSL 1184
            ||..|  |..|..:|......||...|....|    :.:||      ....||.|.:     |.|
Zfish   350 KDRDG--GLCRTGNALLIADLSAIDGSIVGEGKVTDHKNGTYEFVYSVPCEGRFTLT-----LKL 407

  Fly  1185 ------GLPLR-QANELA--SSDDDGSKNGLGSPTSPTVAAAVAAAGITGAAGTIPKQVY-LRKR 1239
                  |.|.. :||:..  |...|..|..|.||.:..|.......         |..:| ..||
Zfish   408 YDQHIRGSPFSIRANKPTDISLTADVDKKRLKSPGNSHVKQRAIKR---------PASMYSTGKR 463

  Fly  1240 QQ-------LFQLGGRGSEPGSFTWPRGLAVGPDNSIVVADSSNHRVQVFDSNGIFVKEFGEYGN 1297
            ::       :|::|.:|...|.||..:|:|......:::|||:|..||:|.::|.|...||..|.
Zfish   464 KENPIEDDLIFRIGTKGRNKGEFTNLQGVAASSVGKVLIADSNNQCVQIFLNDGQFKGRFGIRGR 528

  Fly  1298 GEGEFDCLAGVAVNRIGQYIIADRYNHRIQVLDPQGRFLRAFGSQGTADGKFNYPWGVTTDALGF 1362
            ..|:.....||||:..|..||||..|..:.:....|:|....||     ||...|.||:.|..|.
Zfish   529 SPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKSKIGS-----GKLMGPKGVSVDRNGH 588

  Fly  1363 IYVCDKENHRVQVFQSDGSFVGKFGSCGRGEGQLEHPHYIAVSNTNRVIVSDSNNHRIQIFDVNG 1427
            |.|.|.::..|.:||.:|..|.|||:.|..:.|...||:.||:..|.|||:|.:||.:::|...|
Zfish   589 IIVVDNKSCCVFIFQPNGKLVSKFGNRGNSDKQFAGPHFAAVNQNNEVIVTDFHNHSVKVFSPEG 653

  Fly  1428 KVLSTVGGEGSDDGQFKFPRGVAVDDQGYIFVADSGNNRIQIFNPDGSFLKTFGSWGSGDSEFKG 1492
            :.:...|..|..:|||..|.|||||..|.|.|||.||:|||:|:..||||....:  |.|..: |
Zfish   654 EFILKFGSNGEGNGQFNAPTGVAVDANGNIIVADWGNSRIQVFDSSGSFLSYINT--SADPLY-G 715

  Fly  1493 LEGVAIMSNGNILVCDRENHRVQVF 1517
            .:|:|:.|:|:::|.|..||..:|:
Zfish   716 PQGLALTSDGHVVVADSGNHCFKVY 740

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnNP_001137707.1 RING 9..54 CDD:238093
zf-B_box 94..>122 CDD:279037
iSH2_PI3K_IA_R 131..231 CDD:304922
NHL_TRIM71_like 1234..1517 CDD:271324 108/290 (37%)
YncE 1253..>1517 CDD:225926 102/263 (39%)
NHL repeat 1258..1297 CDD:271324 13/38 (34%)
WD40 repeat 1261..1304 CDD:293791 14/42 (33%)
NHL repeat 1305..1344 CDD:271324 14/38 (37%)
WD40 repeat 1345..1377 CDD:293791 11/31 (35%)
NHL repeat 1352..1388 CDD:271324 15/35 (43%)
NHL repeat 1396..1436 CDD:271324 14/39 (36%)
WD40 repeat 1402..1439 CDD:293791 13/36 (36%)
NHL repeat 1445..1475 CDD:271324 17/29 (59%)
WD40 repeat 1446..1485 CDD:293791 21/38 (55%)
NHL repeat 1491..1517 CDD:271324 9/25 (36%)
trim2aNP_001014393.1 RING 23..66 CDD:238093 6/17 (35%)
BBOX 112..153 CDD:197662 8/40 (20%)
BBC 160..286 CDD:128778 27/173 (16%)
IG_FLMN 324..421 CDD:214720 22/103 (21%)
Filamin 324..417 CDD:279024 21/99 (21%)
NHL_TRIM2_like 471..744 CDD:271330 106/278 (38%)
YncE 486..>735 CDD:225926 99/256 (39%)
NHL repeat 489..528 CDD:271330 13/38 (34%)
NHL repeat 536..575 CDD:271330 15/43 (35%)
NHL repeat 578..615 CDD:271330 16/36 (44%)
NHL repeat 622..663 CDD:271330 14/40 (35%)
NHL repeat 669..711 CDD:271330 23/43 (53%)
NHL repeat 714..740 CDD:271330 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 282 1.000 Inparanoid score I2861
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133242at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm25398
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24104
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2677
SonicParanoid 1 1.000 - - X1654
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
88.100

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