| Sequence 1: | NP_001188974.1 | Gene: | CG18605 / 37189 | FlyBaseID: | FBgn0034411 | Length: | 415 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005793.2 | Gene: | TOPORS / 10210 | HGNCID: | 21653 | Length: | 1045 | Species: | Homo sapiens |
| Alignment Length: | 29 | Identity: | 10/29 - (34%) |
|---|---|---|---|
| Similarity: | 15/29 - (51%) | Gaps: | 4/29 - (13%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 178 ILGLAYKSISVDGVMPVFYNMF----NQG 202 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| CG18605 | NP_001188974.1 | None | |||
| TOPORS | NP_005793.2 | E3 ubiquitin-protein ligase activity | 1..195 | 10/29 (34%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..35 | ||||
| Required for DNA-binding | 51..374 | 10/29 (34%) | |||
| RING-HC_Topors | 100..145 | CDD:438236 | 4/10 (40%) | ||
| Interaction with SUMO1. /evidence=ECO:0000269|PubMed:14516784 | 437..654 | ||||
| Required for sumoylation and localization to discrete nuclear foci | 437..574 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 442..475 | ||||
| Interaction with TOP1. /evidence=ECO:0000269|PubMed:10352183 | 456..882 | ||||
| Interaction with p53/TP53. /evidence=ECO:0000269|PubMed:10415337 | 456..731 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 511..692 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 713..936 | ||||
| Interaction with UBE2I. /evidence=ECO:0000269|PubMed:14516784 | 854..917 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||