DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Topors and topors

DIOPT Version :9

Sequence 1:	NP_001261083.1	Gene:	Topors / 37188	FlyBaseID:	FBgn0267351	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	XP_002940310.1	Gene:	topors / 734040	XenbaseID:	XB-GENE-994244	Length:	1018	Species:	Xenopus tropicalis

Alignment Length:	1085	Identity:	255/1085 - (23%)
Similarity:	398/1085 - (36%)	Gaps:	252/1085 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EAEEPVSAGPDNANAIG---EPGTSASAAEENGTVERNSPPPNCAICLSRCRRKCFTDSCMHQFC 123
            ||.:.:.|...|..::.   .|....|..:.:||....||...|.|||.|.......|.|:|:||
Frog    16 EANDTMMASSSNNYSLDGSFSPQAGTSKLQNHGTATDASPDSKCPICLDRFDNVSHLDRCLHRFC 80

  Fly   124 FKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENPSLRYHIVRRPRY-TP 187
            |:|:.||:|.|.|||||||||.:|.|:|:..||:..|.::     ||.|.|.......|.|| |.
Frog    81 FRCIQEWAKNKAECPLCKQPFYSIFHSVKAEDDFKEYVLR-----PTMNGSFASPDGHRFRYRTT 140

  Fly   188 LVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYS------RFEPYRSELMNYYQHDQD-- 244
            :.::..|.:..:.:                 ::.:|::|      .||.:.::  |.:|..::
Frog   141 MSRDNHVAIRTLRS-----------------SSTQRTFSPPDNGILFEGFSNQ--NLHQRGEEIH 186

  Fly   245 -----------ASTSG-SLSQL-------WRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPA 290
                       ||..| |:.|:       :||.:|...:....:.|.  |.:|:.||.|:|.|||
Frog   187 QMIRRLASRRQASAEGRSMRQIQEQELINFRRALYRSGIRVRNIQDG--GRYRDISAEFFRRNPA 249

  Fly   291 QIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELF 355
            .:|||:||:.|::..|..:....||.|..::...:....:....|...|.|:|..||.|||||..
Frog   250 CLHRLVPWLKRELTVLFGSHGSLVNIVQHIIMSNVTRYDMESQAFVEDLRPFLLHRTDHFIHEFV 314

  Fly   356 NFARSPYDINGYDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWS 420
            ||||.||:|..||....|                               |..|.:...|
Frog   315 NFARCPYNIEAYDQHANY-------------------------------DCPAPSYEEG------ 342

  Fly   421 PPRVRPSTSVIVTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVA-SEE 484
               .|..:|||..:|....:....:.|.|   ||:.   .|....:|...:.|....|:|| |..
Frog   343 ---SRSESSVITISPDEADTRDPIIPSAG---PGVG---QTAWDDETPGPSYSTLEQASVAVSTT 398

  Fly   485 PEVIEIDDGDAAANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPH 549
            .::.|..|.:..:..:.:.....|..:......:.|.               |:||.|..:||..
Frog   399 LDISESSDDEPPSIRQTSQEVSNSEPTENLQDQSFPT---------------DDCVIVGYVKPLA 448

  Fly   550 MRTPEQVSLDSNSDSDVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGK 614
            .||||.|.|.|:|:|.:..|..:....|.......|..|.|..:|  ..|:.......:...:||
Frog   449 ERTPELVELSSDSESSLSEVKTEDAKKPTIKPFFLSDSSELSRSS--SSLYTPAKEKRSRKTKGK 511

  Fly   615 NWKLVMAQTRRLDQLRTLRSIRSKKSRRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTT 679
            ......:.:|:          :.|...|..:.:|.|.|...|:.:.|.:...|.|.:..|.||..
Frog   512 TTSSKHSHSRK----------KEKGKCRLDLTSRKDKGDLNSNYALSRWRDRSRSSDCYSRSSRN 566

  Fly   680 NSEPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESSS--DSP 742
            .|.    .||:|..:....|..|..|...:.||.:              ||...:..|.|  ...
Frog   567 KSH----NSRRRHCSKNNLKPRSPEKSRHKSRKGR--------------KKSSSRDRSLSWRSRT 613

  Fly   743 SSSDDESGGDSSESSGQP-NTNNNKS-SSDSDDDSAVNMQLSALRATLKAEATLEDRKPVKLELQ 805
            .|...||..:..|||.:. |.:..:| |.|||:|.:.|    ..|::.:.|.|...|.
Frog   614 VSLTSESSRERCESSSRSRNRSRGRSRSHDSDNDFSSN----NYRSSYQWEYTYYSRN------- 667

  Fly   806 LPDDD-------------------QAGPLHSRMTPSPRED--NEPGCSAPKRRRSCSHSNQSSQS 849
             .|.|                   .|.|.:...:.|.::|  .|.|..|.|:.|...:.::|..|
Frog   668 -RDRDGYEQSYRRRTCGRGRYSRPSASPEYKIQSYSEKKDTRKERGYIASKQYRRERYRSRSRSS 731

  Fly   850 ASLASSSTA-TSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTLTQPVNIGLFNE 913
            :.:.:|.|. |.|..|           ||....:.| .:|:.:...:..|:.:..:  ..|....
Frog   732 SQMNTSGTEHTRSDKP-----------SGKRKYKTH-HLEKQEREGNNREVPSAKE--KEGGLQA 782

  Fly   914 HYNSAENSMGMLSNTLCDS----PQTL--AADDANLENYFDTDADPEA-------------SRER 959
            ...|..|..|.|.|.|..|    .|.|  .|...::|..::..|...|             .|.|
Frog   783 GKTSLGNHTGSLKNDLMGSSSEPKQKLRKKARSPSVEIVYEGKAVEGAKHHKKKKKKKHKKKRRR 847

  Fly   960 DAYSLEAA----IDVVGESELQIAED------TATATEEQDEEDEED--EDQEEDDQEEEKAAEE 1012
            :..:..||    |.:..:|:..:.||      ::...|.:...|..:  ..|...........|.
Frog   848 EHTNSPAASPIIITIDSDSDTPMVEDLPCNDHSSLVPENKTSIDSTNFMHSQSPPTSTTVSTTEV 912

  Fly  1013 EEEEEEDDD-------DSDNH-------------DENDENQGLLP 1037
            ...|..|.|       .|:.|             |::.:.|.|||
Frog   913 LSGERADSDSKASDLCSSNRHLDAATGILDGLHFDDSSDEQNLLP 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Topors	NP_001261083.1	RING	102..144	CDD:238093	23/41 (56%)
topors	XP_002940310.1	RING-HC_Topors	59..98	CDD:319488	20/38 (53%)
topors	XP_002940310.1	RING-HC finger (C3HC4-type)	59..97	CDD:319488	19/37 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5390
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3780
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003652
OrthoInspector	1	1.000	-	-		oto102904
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9253
SonicParanoid	1	1.000	-	-		X4653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.080