DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Topors and Toporsl

DIOPT Version :9

Sequence 1:	NP_001261083.1	Gene:	Topors / 37188	FlyBaseID:	FBgn0267351	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001343222.1	Gene:	Toporsl / 68274	MGIID:	1915524	Length:	683	Species:	Mus musculus

Alignment Length:	792	Identity:	148/792 - (18%)
Similarity:	251/792 - (31%)	Gaps:	257/792 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 RFEPYRSELMNYYQHDQDASTSGSLSQLWRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPAQ 291
            |..|:...|.::..|         :...:||.:|...::...|..|  |..|.:||.:::.||:.
Mouse   116 RLPPHSVSLSHFRDH---------VVVKFRRALYYSGIWVKYVQGS--GLKRFFSAHYFKRNPSS 169

  Fly   292 IHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELFN 356
            :|||:||:.|::..:..:..::|..::|.:...:...:|....|...|.|||.:.|.||:||..:
Mouse   170 LHRLIPWLKRELTAICGDYGYTVKNILTAILHHMTKFNLNSEAFTHLLEPYLFQYTQHFLHEFIS 234

  Fly   357 FARSPYDINGYDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWSP 421
            |..|.|::..||....|...|::                        .......::|   |.:|.
Mouse   235 FVDSSYNMETYDRNAIYQCPVSK------------------------SSKKKSTVSA---PAFSF 272

  Fly   422 PRVRPSTSVIVTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVASEEPE 486
            |:   ..|.:.:..|...|                 ::|.|...|               |.:..
Mouse   273 PQ---ELSFMKSQRGIKQS-----------------KKTWNKTGQ---------------SSDSG 302

  Fly   487 VIEIDDGDAAANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPHMR 551
            :.:...|.::.|.:::                   |.|                    .||
Mouse   303 LKQFPKGHSSKNPQIS-------------------TTH--------------------QKP---- 324

  Fly   552 TPEQVSLDSNSDSDVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNW 616
                             .|::|....|            :..|.|   |.|.    .......||
Mouse   325 -----------------ANKRHVWTKD------------EWGSDD---FRGV----VCTTNSLNW 353

  Fly   617 KLVMAQTRRLDQLRTLRSIRSKKSRRSSMPARSDSGSSPSSCSSSSFHFSSSSDEDSSDSSTTNS 681
            ..:.|  ||||:.......|.|||..:.:|        |........|.:|.:...:...|  |.
Mouse   354 AYLRA--RRLDKEYYRNDNREKKSESTKLP--------PGHVQDLKSHETSPNIFRALVDS--NQ 406

  Fly   682 EPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESS--SDSPSS 744
            .||||.:.:........::....|:.:.::|.::.:::.|          ||.|:..  ..|.|.
Mouse   407 APPKKYNIRETNVLDPGQQVHYQKKETERKKLEESSLKAL----------QRLPKERILIKSKSR 461

  Fly   745 SDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALRATLKAEATLEDRKPVKLELQLPDD 809
            ..:.|....||:|..|..|:...:|.|                         :|.|:.. |....
Mouse   462 ESNHSCLCVSENSTSPTRNDKMLTSIS-------------------------KKMVRCS-QSSQC 500

  Fly   810 DQAGPLHSRMTP---SPREDNEPGCSAPKRRRSCSHSNQSSQSASLASSSTATSSSAPLSSFAWG 871
            .:.|..|||.|.   |||        .|:.:..|....:.|.|...::.|...|..:...:.:.|
Mouse   501 VEVGSHHSRRTQRQYSPR--------TPRSKSWCVRIRKQSMSRGQSNLSLRESHRSKHCALSKG 557

  Fly   872 AAGFSGDPLMRGHPAMEEHDIANSLIELS-------TLTQPVN-----IGLFNEHYNSAENSMGM 924
            :|          |.....:.:|:    ||       .||...|     :|..........:|:..
Mouse   558 SA----------HGCESTYRVAS----LSPVHHDQVCLTAGKNCKCASMGEGESQTGGHCDSLSC 608

  Fly   925 LSNTLCDSPQTLAADDANLENYFDTDADPEASRERDAYSLEAAIDVVGESELQIAEDTATATEEQ 989
            |....|.||..|.....:|..        ..:|.|.....:.....||         |.|..|.:
Mouse   609 LKTEKCHSPSKLGMKGKHLVG--------RVTRIRTHRRKKPKYQCVG---------TQTTAEFR 656

  Fly   990 DE-EDEEDEDQE 1000
            |: .|.||:.|:
Mouse   657 DDLGDLEDKSQK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Topors	NP_001261083.1	RING	102..144	CDD:238093
Toporsl	NP_001343222.1	DUF4553	<357..514	CDD:373549	43/204 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4430
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42808
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.790