DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Topors and Topors

DIOPT Version :9

Sequence 1:	NP_001261083.1	Gene:	Topors / 37188	FlyBaseID:	FBgn0267351	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001102128.1	Gene:	Topors / 362501	RGDID:	1305270	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	245/1040 - (23%)
Similarity:	387/1040 - (37%)	Gaps:	258/1040 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EPVSAGPDNANAIGEPGTS-----ASAAEE---------------NGTVERN-SPPPNCAICLSR 108
            |..|:||      ..|.|:     ||||:|               ..||..: ||...|.|||.|
  Rat    52 ELASSGP------AVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDR 110

  Fly   109 CRRKCFTDSCMHQFCFKCLCEWSKIKPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENP 173
            .....:.|.|:|:|||:|:.||||.|.|||||||||.:|.|:||..||:..|.::     |:.|.
  Rat   111 FDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLR-----PSYNG 170

  Fly   174 SLRYHIVRRPRYTPLVQNQAVIVNDIEAAIAAGAAGEDVLSAAEVAAGRRSYS------RFE--- 229
            |.....|||.||      :..:..:..|::.:.::          ...||:.:      .||
  Rat   171 SFTAPEVRRFRY------RTTMTRERNASLYSPSS----------TVSRRTSTPPDSGVLFEGLG 219

  Fly   230 ----PYRSELMNYYQH----DQDASTSGSLSQL-------WRRYVYDRKLYALPVSDSVTGHFRE 279
                |...::..:.:|    ...|:...||.::       :||.:|...:....:.|.  |.:|:
  Rat   220 ISTRPRDVDIPQFMRHMALRGPTATDERSLRKVQEQDIINFRRTLYRAGVRVRSIEDG--GRYRD 282

  Fly   280 WSARFYRNNPAQIHRLMPWIHRDIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLG 344
            .||.|:|.|||.:|||:||:.|::..|.......||.|..::...:....|....|...|.|:|.
  Rat   283 ISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLL 347

  Fly   345 ERTSHFIHELFNFARSPYDINGYDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDAD 409
            .||.|||||..:|||||:::..:|....|....:.|         |...|:...:.:...:::|.
  Rat   348 NRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSE---------EGSRSDSSVITISPDEAEAQ 403

  Fly   410 AINAGFSPDWSPPRVRPSTSVIVTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSM 474
            .::...|                         ::..|....|.||.|..     .|:.|.:.:|.
  Rat   404 ELDVNVS-------------------------TIRQAPWDDETPGPSYS-----NSEQVHVGVSS 438

  Fly   475 RRPAAVASEEPEVIEIDDGDAAANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDEC 539
            ...::.:|:|    |:..|.||:..:....||..|.                 :|.|||   |.|
  Rat   439 LLNSSDSSDE----ELVSGGAASQIQGVQANDDVNN-----------------DSDSSS---DNC 479

  Fly   540 VFVLELKPPHMRTPEQVSLDSNSDS-------DVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQ 597
            |.|..:||...||||.|.|.|:|:.       :.|...||.::.....::.....||..:..:|:
  Rat   480 VIVGFVKPLAERTPELVELSSDSEELGSYEKMETVKTQEQEQSYSSGDSDASRASSPRSVLGKDE 544

  Fly   598 GLFMGPSTSGAAANRGKNWKLVMAQTRRLDQLRTLRSIRSKKSRRSSMPARSDSGSSPSSCSSSS 662
            .:......|....|..|..|               || .|..:.|.|...|.|...||.:.....
  Rat   545 QMGKSHCDSDTRINSKKEEK---------------RS-TSLSTPRDSSSTRGDRACSPYNHRHRK 593

  Fly   663 FHFSSSSDEDSSDSSTTNSEPPKKKSRKRVANNKRSK-KESIGKRTSRKRKAKDQNMEMLEQQQI 726
            ...|.|||..|...|..:....:|...|:...||||: :||..|..:||
  Rat   594 GGRSRSSDSRSQSRSGHDQRNHRKHHGKKRLKNKRSRSRESSSKPRARK---------------- 642

  Fly   727 SQKKPQRQPESSSDSPSSSDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALR----AT 787
             .||..|..:||....|.:...|.|.:|.|..:.:.:..:.|...:.|...      ||    :.
  Rat   643 -DKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYY------LRNNYGSK 700

  Fly   788 LKAEATLEDRKPVKLELQLPDDDQAGPLHSRMTPS----PREDNEP-----GCSAPKRRRSCSHS 843
            .|.|.|...|.        .|.|.....:.|.|.|    .|:.:.|     ..|.....|..:||
  Rat   701 YKWEYTYYSRN--------KDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARRKNHS 757

  Fly   844 N------QSSQSASLASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTL 902
            .      :..:|.|::|:.:.|:|:.|             |.:....|..:.......|.:.:..
  Rat   758 ERKYYYYERHRSRSVSSNRSRTTSAVP-------------DRMRNEKPGGKRKYKTRHLEDTNEE 809

  Fly   903 TQPVNI---GLFNEHYNSAENSMGMLSNTLCDSPQTLAADDANLENYFDTDADPEAS-------- 956
            .||...   .:...||               ..|..|   |...::..|:.:|...|
  Rat   810 AQPSRAFASRVKESHY---------------QKPSKL---DGGSKDESDSFSDSRPSDRETKHKR 856

  Fly   957 RERDAYSLEAAIDVVGESELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEEEEEEEDDD 1021
            |:|.|.||  ::::|.|.:   |.||:...:::.::.::...:...|...........:.:.|.|
  Rat   857 RKRRARSL--SVEIVYEGK---ATDTSKHHKKKKKKHKKKHRKHHGDNTSRSPVVITIDSDSDGD 916

Fly 1022 1021
Rat 917 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Topors	NP_001261083.1	RING	102..144	CDD:238093	24/41 (59%)
Topors	NP_001102128.1	RING	103..146	CDD:238093	27/42 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339569
Domainoid	1	1.000	129	1.000	Domainoid score	I5170
eggNOG	1	0.900	-	-		E1_KOG4430
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3845
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003652
OrthoInspector	1	1.000	-	-		otm44874
orthoMCL	1	0.900	-	-		OOG6_104232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4653
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.650