DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Topors and Topors

DIOPT Version :9

Sequence 1:NP_001261083.1 Gene:Topors / 37188 FlyBaseID:FBgn0267351 Length:1038 Species:Drosophila melanogaster
Sequence 2:NP_598858.2 Gene:Topors / 106021 MGIID:2146189 Length:1033 Species:Mus musculus


Alignment Length:1112 Identity:259/1112 - (23%)
Similarity:406/1112 - (36%) Gaps:301/1112 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ELGASVIVEPGLEGSNAGGRTLPAAAIKFADLTESGSESGDNEAEEPVSAGPDNANAIGEPGTSA 84
            |.|.:..:.|..||.....|.....:.:......|..|...|....|.:|..:         ..|
Mouse    15 EEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSE---------IMA 70

  Fly    85 SAAEE---------------NGTVERN-SPPPNCAICLSRCRRKCFTDSCMHQFCFKCLCEWSKI 133
            |||:|               ..||..: ||...|.|||.|.....:.|.|:|:|||:|:.||||.
Mouse    71 SAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKN 135

  Fly   134 KPECPLCKQPFRTIIHNVRTLDDYDRYPVQTTSPVPTENPSLRYHIVRRPRY-TPLVQNQAVIVN 197
            |.|||||||||.:|.|:||..||:..|.::     |:.|.|.....|||.|| |.:.:.::..:.
Mouse   136 KAECPLCKQPFDSIFHSVRAEDDFKEYVLR-----PSYNGSFTNPEVRRFRYRTTMTRERSASLY 195

  Fly   198 DIEAAIA--------AGAAGE-----------DVLSAAEVAAGR-------RSYSRFEPYRSELM 236
            ...:.::        :|...|           |:.......|.|       ||..:.:  ..:::
Mouse   196 SPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQ--EQDII 258

  Fly   237 NYYQHDQDASTSGSLSQLWRRYVYDRKLYALPVSDSVTGHFREWSARFYRNNPAQIHRLMPWIHR 301
            |:                 ||.:|...:....:.|.  |.:|:.||.|:|.|||.:|||:||:.|
Mouse   259 NF-----------------RRTLYRAGVRVRSIEDG--GRYRDISAEFFRRNPACLHRLVPWLKR 304

  Fly   302 DIMCLLRNAAHSVNTVMTLMSDLLPMTSLLGPTFRRRLSPYLGERTSHFIHELFNFARSPYDING 366
            ::..|.......||.|..::...:....|....|...|.|:|..||.|||||..:|||||:::..
Mouse   305 ELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAA 369

  Fly   367 YDHVVQYSARVAEEVEVDLLDMVETQSSNGDDLNLEVGDSDADAINAGFSPDWSPPRVRPSTSVI 431
            :|....|....:.|                     |...||:..|.  .|||      ...|..:
Mouse   370 FDQHANYDCPPSSE---------------------EGSRSDSSVIT--ISPD------EAETQEL 405

  Fly   432 VTNPGATHSFSVTMASDGSELPGISIRRTTNVGSQTVAINLSMRRPAAVASEEPEVIEIDDGDAA 496
            ..|     :.:|..|....|.||.|..     .|:.|.:.:|....::.:|:|    |:..|...
Mouse   406 DMN-----ASTVRQAPWDDETPGPSYS-----SSEQVHVGVSSLLNSSDSSDE----ELVSGGTT 456

  Fly   497 ANAEVAAINDGSNTSRRHAGATLPVTAHIELESSSSSGDEDECVFVLELKPPHMRTPEQVSLDSN 561
            :..:....||..|.                 :|.|||   |.||.|..:||...||||.|.|.|:
Mouse   457 SQIQGVQTNDDVNN-----------------DSDSSS---DNCVIVGFVKPLAERTPELVELSSD 501

  Fly   562 SDS-------DVVFVNEQHEAAPDAIAENRSTQSPLDLASRDQGLFMGPSTSGAAANRGKNWKLV 619
            |:.       :.|...||.::.....::.....||..:..:|:.:......|             
Mouse   502 SEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDS------------- 553

  Fly   620 MAQTRRLDQLRTLRSIRSKK--SRRSSMPARSDSGSSPSSCSSSSFHF-------SSSSDEDSSD 675
              .||          |.|||  .|.:|:||..||.|:......|.::.       |.|||..|..
Mouse   554 --DTR----------ISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQS 606

  Fly   676 SSTTNSEPPKKKSRKRVANNKRSKKESIGKRTSRKRKAKDQNMEMLEQQQISQKKPQRQPESSSD 740
            .|..:....:|..:||:.|.:...:||    :||.|..||             ||..|..:||..
Mouse   607 RSGHDPRNHRKHGKKRLRNKRSRSRES----SSRPRARKD-------------KKRSRTRDSSWS 654

  Fly   741 SPSSSDDESGGDSSESSGQPNTNNNKSSSDSDDDSAVNMQLSALR----ATLKAEATLEDRKPVK 801
            ..|.:...|.|.:|.|..:.:.:..:.|...:.|...      ||    :..|.|.|...|.   
Mouse   655 RRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYY------LRNNYGSKYKWEYTYYSRN--- 710

  Fly   802 LELQLPDDDQAGPLHSRMTPS----PREDNEP-----GCSAPKRRRSCSHSN------QSSQSAS 851
                 .|.|.....:.|.|.|    .|:.:.|     ..|.....|..:||.      :..:|.|
Mouse   711 -----KDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRS 770

  Fly   852 LASSSTATSSSAPLSSFAWGAAGFSGDPLMRGHPAMEEHDIANSLIELSTLTQPVNIGLFNEHYN 916
            ::|:.:.|:|:.|             |.:....|..:.......|...|...||.     .|..:
Mouse   771 VSSNRSRTTSAGP-------------DRVRNEKPGGKRKYKTRHLEGTSEEAQPA-----REFTS 817

  Fly   917 SAENSMGMLSNTLCDSPQTLAADDANLENYFDTDADPEAS--------RERDAYSLEAAIDVVGE 973
            ..::|....|..           |.:.:|..|:.:|..:|        |.|...||  ::::|.|
Mouse   818 KGKDSHYQKSKL-----------DGSYKNESDSFSDSRSSDRETKHKRRRRRTRSL--SVEIVYE 869

  Fly   974 SELQIAEDTATATEEQDEEDEEDEDQEEDDQEEEKAAEEEEEEEEDDD----------DSDNHDE 1028
            .:   |.||:                 :..::::|..:::.::...|:          |||:..|
Mouse   870 GK---ATDTS-----------------KHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGE 914

  Fly  1029 NDENQGL 1035
            ::...|:
Mouse   915 SEVKAGI 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ToporsNP_001261083.1 RING 102..144 CDD:238093 24/41 (59%)
ToporsNP_598858.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 6/20 (30%)
Required for DNA-binding. /evidence=ECO:0000250 52..376 105/366 (29%)
RING 103..146 CDD:238093 24/42 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..477 11/62 (18%)
Interaction with SUMO1. /evidence=ECO:0000250 438..654 54/224 (24%)
Sumoylation and localization to discrete nuclear foci. /evidence=ECO:0000250 438..574 37/142 (26%)
Interaction with TOP1. /evidence=ECO:0000250 457..879 102/456 (22%)
Interaction with p53/TP53. /evidence=ECO:0000250 457..731 69/289 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..692 52/211 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..934 44/239 (18%)
Interaction with UBE2I. /evidence=ECO:0000250 851..914 10/62 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 970..1033 10/71 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835931
Domainoid 1 1.000 125 1.000 Domainoid score I5486
eggNOG 1 0.900 - - E1_KOG4430
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 182 1.000 Inparanoid score I3957
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003652
OrthoInspector 1 1.000 - - otm42808
orthoMCL 1 0.900 - - OOG6_104232
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9253
SonicParanoid 1 1.000 - - X4653
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.680

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