| Sequence 1: | NP_611388.1 | Gene: | Topors / 37188 | FlyBaseID: | FBgn0267351 | Length: | 1038 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005793.2 | Gene: | TOPORS / 10210 | HGNCID: | 21653 | Length: | 1045 | Species: | Homo sapiens |
| Alignment Length: | 286 | Identity: | 55/286 - (19%) |
|---|---|---|---|
| Similarity: | 106/286 - (37%) | Gaps: | 81/286 - (28%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 697 RSHSRSRSNYKHRSSRRHR------SSRSRRDGSERDRSKPPKEPPEPAEPPLVVGPIGPRSPPE 755
Fly 756 PAPQMPPAA----AQGEPEA-----EVGMVAGGPPPPPEPPNGIGAAMDDEDEEPSMVSESFKKH 811
Fly 812 RIIVRTDTLGAKTTKEIEEEVRERLLRQ------------------QMERELEKRKERELEKQKE 858
Fly 859 RE-----LEKRKERELEKR-KE----------------------------RELEKHQER--ELQK 887
Fly 888 RKERELEKHQERELQKR-KERELQKR 912 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Topors | NP_611388.1 | RING-HC_Topors | 99..144 | CDD:438236 | |
| TOPORS | NP_005793.2 | E3 ubiquitin-protein ligase activity | 1..195 | 33/190 (17%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..35 | 4/21 (19%) | |||
| Required for DNA-binding | 51..374 | 50/248 (20%) | |||
| RING-HC_Topors | 100..145 | CDD:438236 | 6/44 (14%) | ||
| Interaction with SUMO1. /evidence=ECO:0000269|PubMed:14516784 | 437..654 | ||||
| Required for sumoylation and localization to discrete nuclear foci | 437..574 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 442..475 | ||||
| Interaction with TOP1. /evidence=ECO:0000269|PubMed:10352183 | 456..882 | ||||
| Interaction with p53/TP53. /evidence=ECO:0000269|PubMed:10415337 | 456..731 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 511..692 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 713..936 | ||||
| Interaction with UBE2I. /evidence=ECO:0000269|PubMed:14516784 | 854..917 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||