DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sano and GAREM1

DIOPT Version :9

Sequence 1:	NP_001286595.1	Gene:	sano / 37185	FlyBaseID:	FBgn0034408	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001229338.1	Gene:	GAREM1 / 64762	HGNCID:	26136	Length:	876	Species:	Homo sapiens

Alignment Length:	861	Identity:	172/861 - (19%)
Similarity:	275/861 - (31%)	Gaps:	302/861 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LPAVAKIIKGQ-------------HQALGVPTLSAPSLQSTALFLSAGKKYQILAQPIKIKEGRK 215
            ||.:|::..|:             |......|::|.||:                      ||..
Human    32 LPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLE----------------------EGHY 74

  Fly   216 PTNVGAKVLIPETYGGYFELLSED---GRSTRCIDSVLELSRRRNARVLVRE--TF-------RC 268
            .  :|.|:.||..|.|.|:||.:|   ....:..:||.|:::....||.|.|  ||       .|
Human    75 V--IGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGEC 137

  Fly   269 QQ----MNRTIHAGELLTTMND--------------------------------NGKY--LQCRN 295
            .:    .|.|:..|:.||.|..                                .||.  |.|.|
Human   138 NEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMN 202

  Fly   296 IK-DEIINLPLDTKAKF---SPIAREDSISGVHTVKNLLLK-RMPVIVRLVHGSAP--------- 346
            .: :|.|:||...|.:|   ||:..:.. .|.||::|::.| |:||.|.:  .|.|
Human   203 HRTNESISLPFQCKGRFSTRSPLELQMQ-EGEHTIRNIVEKTRLPVNVTV--PSPPPRNPYDLHF 264

  Fly   347 --KGLKQPFVPELRLLGCVEIDRIFALPLQKDTDLVPV--PLNAKI-KLQRAKNM-------EQL 399
              :|.:..||.       ::...:....:.::..::|:  ||:..: |....:::       |.|
Human   265 IREGHRYKFVN-------IQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETL 322

  Fly   400 EH-----------FIEYSRFL----------------------DKAQRLLADARDRLQIVDLKLS 431
            .|           ..||||.:                      :.....|:.|||.|.....:||
Human   323 VHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLS 387

  Fly   432 -----EKEKKDSKFNSRN----GG---RLPVVMLPSAAGMASGLAESGYVLRKSASCDSWSKQQQ 484
                 .....:|:.|...    ||   ..|..:||.   ..||.:.|.|:..::      |::..
Human   388 VCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPY---QDSGDSGSDYLFPEA------SEESA 443

  Fly   485 QALSSSEIAEEYNEIDHIYDYVRGLTPLSKGLARFEPICESPTLRSHHTDSGSGNYCSLIRAPVH 549
            .....||:  .|.|:           .|.:|....:|:..|.:.:         |.|...|..|.
Human   444 GIPGKSEL--PYEEL-----------WLEEGKPSHQPLTRSLSEK---------NRCDQFRGSVR 486

  Fly   550 QQATTSGNNNYSSLESNKHSSSGGGHHPGSHHHHHHHVVNHYHHGHIQEDIKPVPPPIET----- 609
            .:..||......:|.:...||......|                        ||||..|.
Human   487 SKCATSPLPIPGTLGAAVKSSDTALPPP------------------------PVPPKSEAVREEC 527

  Fly   610 -------IPGKKPAEKRQRPTLPKLYIKNAHSAGSSSNGNSTGTTHSTSHSHSHSHSHVHSHSHG 667
                   :|.:........|::|...:|.|..           .|.|.|.:.|:..|.:|:.|..
Human   528 RLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQ-----------QTRSPSPTLSYYSSGLHNISVT 581

  Fly   668 QSQSQQQPPTP----------------NGNTGNAVANAAASAVAAAHHGSHGSHG---SHLHPHP 713
            ::.:.....||                ....|:..|.|.:|.::..:|.|..|..   |.....|
Human   582 KTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDP 646

  Fly   714 HASVHPHPHPHHGKVLTPNNHLPSK------EAL-EPQSPLFHIRYKSLSSLQLTPDNNNC-SSV 770
            ..|   :.:|......||..:.|:.      |.| .|.||:         :.:.:...:.| .|.
Human   647 SRS---YSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPV---------TAEFSSSVSGCPKSA 699

  Fly   771 TPPTISAHGKSSGAGVGSGATASGTPGTPGTPPDVGLKCGSILNVHGYLSSPHPLPLPLPHSRSS 835
            :....|...||..|||...:|:  .|..|...|.        |......|...||||.:
Human   700 SYSLESTDVKSLAAGVTKQSTS--CPALPPRAPK--------LVEEKVASETSPLPLKI------ 748

  Fly   836 SSNNHHNPREGTLDSS 851
             .....:|:.|:.|.|
Human   749 -DGAEEDPKSGSPDLS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sano	NP_001286595.1	CABIT	164..400	CDD:289505	69/324 (21%)
GAREM1	NP_001229338.1	CABIT	12..320		68/321 (21%)
		CABIT	32..323	CDD:315418	69/324 (21%)
		Atrophin-1	<436..760	CDD:331285	77/415 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..572		18/110 (16%)
		Necessary for interaction with GRB2. /evidence=ECO:0000269\|PubMed:19509291	498..550		11/75 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	626..664		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..763		8/31 (26%)
		SAM_GAREM	808..874	CDD:188924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14454
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100