DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sano and Garem2

DIOPT Version :9

Sequence 1:	NP_001286595.1	Gene:	sano / 37185	FlyBaseID:	FBgn0034408	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001178803.1	Gene:	Garem2 / 362801	RGDID:	1597138	Length:	879	Species:	Rattus norvegicus

Alignment Length:	860	Identity:	184/860 - (21%)
Similarity:	276/860 - (32%)	Gaps:	298/860 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SKQPLPAVAKIIKGQHQALGVPTLSAPSLQSTALFLSAGKKYQILAQPIKIKEGRKPTNVGAKVL 224
            |:..||.:|.:..|:: |.||      |.:...|..|..:...:.|.  .::||...  :|.|:.
  Rat    25 SRCRLPTLACLGPGEY-AEGV------SERDILLIHSCRQWTTVTAH--TLEEGHYV--IGPKID 78

  Fly   225 IPETYGGYFELLSE--DGRS-TRCIDSVLELSRRRNARVLVRE--TFRCQQM-----------NR 273
            ||..|.|.|:||.:  |.|. .|...||.|::.....|:.|.|  ||..:.:           |.
  Rat    79 IPLQYPGKFKLLEQARDVREPVRYFSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNF 143

  Fly   274 TIHAGELLTTMND--------------------------------------------------NG 288
            |:|||:.||.|..                                                  .|
  Rat   144 TLHAGDELTLMGQAEILCAKTTKERSRFTTLLRKLGRAGALAGIGGPGSMGATGGGGGAARPVRG 208

  Fly   289 KY--LQCRNIK-DEIINLPLDTKAKF---SPIAREDSISGVHTVKNLLLK-RMPVIVRLVHGSAP 346
            |.  |.|.|.: :|.::||...:.:|   ||:..:.. .|.|||:.::.: |:||.| ||....|
  Rat   209 KMPCLICMNHRTNESLSLPFQCQGRFSTRSPLELQMQ-EGEHTVRAIIERVRLPVNV-LVPSRPP 271

  Fly   347 KGLKQPF----VPE---LRLLGCVEIDRIFALPLQKDTDLVPVPLNAKIKLQRAKNMEQLEHFI- 403
               :.|:    |.|   .:|:..:....:..|.|:::.   |.||                ||:
  Rat   272 ---RNPYDLHPVREGHCYKLVSIISKTVVLGLALRREG---PAPL----------------HFLL 314

  Fly   404 --EYSRFL---------DKAQRLLADA----RDRLQIVDLKLSEKE-----KKDSKFNSRNGGRL 448
              :..||.         .:.:||:.|:    |:|....:...:.:|     ..|.....|....|
  Rat   315 LTDTPRFTLPQGLLAGDPRVERLVRDSASYCRERFDPDEYSTAVREAPAELADDCASPRRARLCL 379

  Fly   449 PVVMLPSAAGMASGLAESGYVLRKSASCD------SWSKQQQQALSSSEIAEEYNEIDHIYDYV- 506
            |...:|.:..:.......|..|...:..|      .|:...:.|.:.:||  .|.|:     :|
  Rat   380 PAPRVPGSVRVPGPPGRLGPALPAPSDSDQEYVSPDWAGAPEPAAACAEI--PYEEL-----WVH 437

  Fly   507 RGLTPLSKGLARFEPICESPTLRSHHT------------------DSGSGNYCSLIRAPVHQQAT 553
            :|  |.|...||..|: ..|.|.|..|                  .......|.|:.||
  Rat   438 QG--PESLADARARPL-TGPDLISFGTVGPPQHEPEAPPPPVPPKSEAVKEECRLLHAP------ 493

  Fly   554 TSGNNNYSSLESNKHSSSGGGHHPGSHHHHHHHVVNHYHHGHIQEDIKPVPP----PIETIPGKK 614
                                                            ||||    ....:.|..
  Rat   494 ------------------------------------------------PVPPRGGSSCSRLTGSP 510

  Fly   615 PAEKRQRPTLPKLYIKNAHSAGSSSNGNSTGTTHST-SHSHSHSHS------HVHSHSHG----Q 668
            |..    |..|||  ::.||..||.:..|:|..... |.|.|.|.|      :.:..:.|    .
  Rat   511 PVP----PRFPKL--QSVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDAYSLYCYPCTWGDCKAS 569

  Fly   669 SQSQQQPPTPNGNTGNAVANAAASAVAAAHHGSHGSHGSHLHPHPHASVHPHPHPHHGKVLTPNN 733
            ..|.:.||.|..:|.....:.|:.|:|   ....|...|.|.....|..:.|..|...|...|..
  Rat   570 ESSSRPPPGPLPSTTTQPPSQASRALA---EPLSGRTASLLGADTPAVKNYHSCPPLFKPSRPQK 631

  Fly   734 HLPSKEALEPQSPLFHIRYKSLSSLQLTPDNNNCSSVTPPTISAHGKSSGAGVGSGATASGTP-G 797
            .|....||.|.|...|                       |:.:....|||:...|||.|:.:| .
  Rat   632 SLAPFGALNPFSGPAH-----------------------PSGAPAASSSGSTSTSGALATSSPTH 673

  Fly   798 TPGTPPDVGLKCGSILNVHGYLSSPHPLPLPLPHSRSSSSNNHHNPREGTLDSSRSGGRTSGDSN 862
            :||..|          ...||.::|         |.|.||:....|....||....|..:.
  Rat   674 SPGPGP----------QGQGYSAAP---------SSSLSSSEWQEPALEPLDPFELGQASP---- 715

  Fly   863 KLPEKKTRRLSRPRS 877
              ||.:..|...||:
  Rat   716 --PELELLRCQEPRA 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sano	NP_001286595.1	CABIT	164..400	CDD:289505	72/315 (23%)
Garem2	NP_001178803.1	CABIT	29..338	CDD:403824	77/343 (22%)
Garem2	NP_001178803.1	SAM_GAREM	811..877	CDD:188924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14454
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100