DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh3 and Ephx2

DIOPT Version :9

Sequence 1:	NP_611387.1	Gene:	Jheh3 / 37182	FlyBaseID:	FBgn0034406	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_075225.1	Gene:	Ephx2 / 65030	RGDID:	620732	Length:	554	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	80/369 - (21%)
Similarity:	129/369 - (34%)	Gaps:	125/369 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 YKTEIQGLNIHYIHEKVSEEAKEKKHVYPLLLLHGWPGSVREFFDFIPMLTKHSNITDYAFEVVA 192
            |.|...|:.:|:: |..|..|        :.|.||:|.|...:...||.|.:      ..|.|:|
  Rat   239 YVTVKPGIRLHFV-EMGSGPA--------ICLCHGFPESWFSWRYQIPALAQ------AGFRVLA 288

  Fly   193 PSLVGYGWSDAATRPGFN-------AAEMATVMRNLMLRLGHKKFFIQGGDWGSIIGSNLATLYP 250
            ..:.|||  |:::.|...       ..||.|.:.    :||..:....|.||..::..|:|..:|
  Rat   289 IDMKGYG--DSSSPPEIEEYAMELLCEEMVTFLN----KLGIPQAVFIGHDWAGVLVWNMALFHP 347

  Fly   251 ENVIGYHSNMCVLHTPLAILKGIYGSFFPEKYLPSRFFVDHHFPVWEKWLELLEESGYFHIQATK 315
            |.|....|    |:|||          .|.....|...|....||:...|       ||.    :
  Rat   348 ERVRAVAS----LNTPL----------MPPNPEVSPMEVIRSIPVFNYQL-------YFQ----E 387

  Fly   316 PDTIGAALTSSPVGLASYILEK---------FQTCTNPGL-----KQDFGAIVTVFGLEAVLDNL 366
            |            |:|...|||         |:|..:.||     ..:.|.|     |....::.
  Rat   388 P------------GVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGI-----LVGTPEDP 435

  Fly   367 MVYYLTNSATTAARFYLENVSKT--------YRDLQLD----------RVQSPVPMGCARFRFDL 413
            .|..:|..  ....:|::...|:        ||:.:.:          ::..|..|        :
  Rat   436 KVSKITTE--EEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALGRKILVPALM--------V 490

  Fly   414 ASVTDWQLRDKFPNLTHSM-----YFQQG-----SHFAALEMPA 447
            .:..|..||   |.::.:|     :.::|     .|:..:|.||
  Rat   491 TAEKDIVLR---PEMSKNMENWIPFLKRGHIEDCGHWTQIEKPA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh3	NP_611387.1	EHN	60..165	CDD:283978	10/36 (28%)
Jheh3	NP_611387.1	Abhydrolase	135..>251	CDD:304388	30/122 (25%)
Ephx2	NP_075225.1	Phosphatase	1..224
		HAD-SF-IA-v3	5..203	CDD:273662
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		HAD_like	<142..205	CDD:304363
		Epoxide hydrolase	233..554		80/369 (22%)
		Abhydrolase	239..>379	CDD:304388	45/174 (26%)
		Abhydrolase_1	257..530	CDD:278959	72/347 (21%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910