DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh3 and C45B11.6

DIOPT Version :9

Sequence 1:	NP_611387.1	Gene:	Jheh3 / 37182	FlyBaseID:	FBgn0034406	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001122878.1	Gene:	C45B11.6 / 6418708	WormBaseID:	WBGene00045379	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	140/511 - (27%)
Similarity:	224/511 - (43%)	Gaps:	123/511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VFGLIVALFGAFVGYGYVVFTELTKP-LPKPEFKDDTYWGPGD-AKDFVPDEKIYEFKLQVPQSE 68
            :|.::::::             :.|| .|..|...|.||...| .||   |:.||.|.:.:.:||
Worm    14 IFSILLSIY-------------IHKPDFPPLEIDPDDYWKLDDPEKD---DDTIYSFTIDIKESE 62

  Fly    69 IDDLRKELNRTLRLTEPLDGIAFEYGFNTYALEQFV----DYWRDNYLTK---------WDERQE 120
            :.:.:::|..                      |:|:    |...||||.:         |.:.|.
Worm    63 VSNFKEKLES----------------------ERFLPTLYDTNYDNYLNELKQVLLGFNWKQHQH 105

  Fly   121 LFNSFKQYKTEIQGLNIHYIHEKVSEEAKEKK-HVYPLLLLHGWPGSVREFFDFIPMLTKHS-NI 183
            ..|:||||||||:||.||::  :||...|:|| .|.|||:.||:|||..:||..||:||..| :.
Worm   106 FLNTFKQYKTEIEGLKIHFL--RVSTPPKDKKSRVVPLLIFHGFPGSFWDFFKIIPILTNPSRHG 168

  Fly   184 TDYA------FEVVAPSLVGYGWSDAATRPGFNAAEMATVMRNLMLRLGHKKFFIQGGD-WGSII 241
            .|:.      |||:.|||.|:.:||..|:.||||...|.::..||.||....:|:.|.: :||.:
Worm   169 FDFGVEEAIQFEVIVPSLPGFIFSDKPTKQGFNAIATARIIAKLMYRLNLNNYFVHGTEGYGSDV 233

  Fly   242 GSNLATLYPENVIGYH-SNMCVLHTPLAILKGIYGSFFPEKYL--------PSRFFVDHHFPVWE 297
            .:.|::|||..:.|.| ||..|..|        :.:|...||.        ..|...::.....:
Worm   234 ATLLSSLYPTRIAGLHLSNPFVNPT--------FSTFTLAKYALKAMGQKDEDRENQENRETGKD 290

  Fly   298 KWLELLEESGYF----HIQATKPDTIGAALTSSPVGLASYI------LEKFQTCTNPGLKQDFGA 352
            ...::.:.:.||    ....|.....|||..:||.|.|.||      |..|...||
Worm   291 NRDQMTDLADYFKQDKFAYPTNSQAFGAAFLNSPSGTAKYIESRWKQLSTFFAETN--------- 346

  Fly   353 IVTVFGLEAVLDNLMVYYLTNSATTA-----ARFYLENVSKTYRDLQLDRVQSPVPMGCARFRFD 412
            :..:|.::.:...:.:|:||::..:|     :.|..|:|..:      .:|:.|..:..::
Worm   347 LNELFTMDEIATEIYLYWLTDTLPSALTILDSSFNFESVWLS------SQVRIPTAVSYSK---- 401

  Fly   413 LASVTDWQ-----LRDKFPNLTHSMYFQQGSHFAALEMPAMLFNDFTAFVGKIGLH 463
               .|.|:     |.|::.|||......:|..|..|:....:..|..:||....||
Worm   402 ---QTPWRCSKDILEDRYLNLTRISELPKGGMFHHLQDGHKIAEDIFSFVELQLLH 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh3	NP_611387.1	EHN	60..165	CDD:283978	37/118 (31%)
Jheh3	NP_611387.1	Abhydrolase	135..>251	CDD:304388	51/124 (41%)
C45B11.6	NP_001122878.1	EHN	53..149	CDD:283978	37/119 (31%)
		Abhydrolase	120..>199	CDD:304388	35/80 (44%)
		Abhydrolase_1	140..378	CDD:278959	74/254 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2361
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.910