Protein Alignment Jheh3 and EPHX1

DIOPT Version :10

• Sequence 1: NP_611387.1
• Gene: Jheh3 / 37182
• FlyBaseID: FBgn0034406
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_000111.1
• Gene: EPHX1 / 2052
• HGNCID: 3401
• Length: 455
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 177/455 - (38%)
• Similarity: 268/455 - (58%)
• Gaps: 35/455 - (7%)

  Fly    21 GYVVF------TELTKPLPKPEFKDDTYWGPGDAKDFVPDEKIYEFKLQVPQSEIDDLRKELNRT 79
            |:.::      .|.|.||      :|.:||||.......|:.|..||::....||.||.:.:::
Human    12 GFAIYWFISRDKEETLPL------EDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDK- 69

  Fly    80 LRLTEPLDGIAFEYGFNTYALEQFVDYWRDNYLTKWDERQELFNSFKQYKTEIQGLNIHYIHEKV 144
            .|.|.||:...|.||||:..|::.:.|||:.:  .|.::.|:.|.:..:||:|:||:||:||.|.
Human    70 FRFTPPLEDSCFHYGFNSNYLKKVISYWRNEF--DWKKQVEILNRYPHFKTKIEGLDIHFIHVKP 132

  Fly   145 SEEAKEKKHV-YPLLLLHGWPGSVREFFDFIPMLT--KHSNITD-YAFEVVAPSLVGYGWSDAAT 205
            .:  ....|. .|||::||||||..||:..||:||  |:..::| :.|||:.||:.|||:|:|::
Human   133 PQ--LPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASS 195

  Fly   206 RPGFNAAEMATVMRNLMLRLGHKKFFIQGGDWGSIIGSNLATLYPENVIGYHSNMCVLHTPLAIL 270
            :.|||:...|.:...||||||.::|:||||||||:|.:|:|.|.|.:|.|.|.||.::.:..:.|
Human   196 KKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTL 260

  Fly   271 KGIYGSFFPEKYLPSRFF------VDHHFPVWEK-WLELLEESGYFHIQATKPDTIGAALTSSPV 328
            ..:.|..|      .||.      |:..:||.|| :..|:.||||.|||.|||||:|:||..|||
Human   261 TLLLGQRF------GRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPV 319

  Fly   329 GLASYILEKFQTCTNPGLKQ-DFGAIVTVFGLEAVLDNLMVYYLTNSATTAARFYLENVSKTYRD 392
            |||:||||||.|.||...:. :.|.:...|.|:.:|.|:|:|:.|.:..::.|||.||:.:.:..
Human   320 GLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMT 384

  Fly   393 LQLDRVQSPVPMGCARFRFDLASVTDWQLRDKFPNLTHSMYFQQGSHFAALEMPAMLFNDFTAFV 457
            .:.:|::..||.|.:.|.|:|....:..:|.|:|.|....|..:|.||||.|.|.:|..|...|:
Human   385 QKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFL 449

  Fly   458  457
            Human   450  449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jheh3	NP_611387.1	EHN	57..170	CDD:461913	43/113 (38%)
		MenH	131..>255	CDD:440361	61/127 (48%)
EPHX1	NP_000111.1	EHN	48..157	CDD:461913	43/113 (38%)
		Abhydrolase_1	142..404	CDD:395444	115/267 (43%)