DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh3 and W01A11.1

DIOPT Version :9

Sequence 1:	NP_611387.1	Gene:	Jheh3 / 37182	FlyBaseID:	FBgn0034406	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_504650.1	Gene:	W01A11.1 / 179036	WormBaseID:	WBGene00020909	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	460	Identity:	179/460 - (38%)
Similarity:	247/460 - (53%)	Gaps:	69/460 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LPKPEF--KDDTYWGPGDAKDFVPDE-KIYEFKLQVPQSEIDDLRKELNRTLRLTEPL--DGIAF 91
            ||:.|.  :::.|:|.|.||   ||. :|..||:.|.||.||||:..| :..|::..:  |...|
Worm    24 LPEKEINVEENNYYGSGKAK---PDNTEIKPFKVNVEQSVIDDLKHRL-QNARISHSVLEDSDDF 84

  Fly    92 EYGFNTYALEQFVDYWRDNYLTKWDERQELFNSFKQYKTEIQGLNIHYIHEKVSEEAKEKKHVYP 156
            .||||:..|.:..|||.:.|  .|.:::...|.|.|:||||:||.:|::|.|   ..|..|:|.|
Worm    85 YYGFNSKQLLKLRDYWLNKY--DWRKQEATINQFPQFKTEIEGLQVHFLHVK---PPKSYKNVKP 144

  Fly   157 LLLLHGWPGSVREFFDFIPMLT---KHSNITDYAFEVVAPSLVGYGWSDAATRPGFNAAEMATVM 218
            :|:.|||||:|.||:.|||:||   ||...:|:||||:|||:.||||||...:.||:....|.|.
Worm   145 ILVAHGWPGNVFEFYKFIPLLTDPKKHGIDSDFAFEVIAPSIPGYGWSDQPKKTGFSQLACARVF 209

  Fly   219 RNLMLRLGHKKFFIQGGDWGSIIGSNLATLYPENVIGYHSNMCVL---HTPLAILKGIYGSFFPE 280
            |.||||||:.||::||||||:||.|.|..:||:||:..|.||...   ...|.....|.|...|.
Worm   210 RKLMLRLGYNKFYLQGGDWGAIITSLLTKVYPQNVMALHLNMMPAMPGANALGTFYDILGWLIPS 274

  Fly   281 KYLPSRFFVDHHFPVWEKWLELLEESGYFHIQATKPDTIGAALTSSPVGLASYILEKFQTCTN-- 343
            . |.|:.....|.| :.|:..|:.|:||.|:|||||||.|.:|..||:|||:||:|||.|.||
Worm   275 T-LSSKEIQKTHNP-FSKFGLLIVETGYMHLQATKPDTAGTSLNDSPIGLAAYIIEKFSTWTNTE 337

  Fly   344 ----PGLKQDFGAIVTVFGLEAVLDNLMVYYLTNSATTAARFYLENVSKTYRDLQLDR------- 397
                |.     |.:...|..:.:|..:|:|:...:..::.||        ||::.|||
Worm   338 NRALPD-----GGLNKRFTNDELLTIVMIYWTNGNIVSSQRF--------YREMFLDRRCEALGK 389

  Fly   398 --VQSPVPMGCARFRFDLASVTDWQLRDKFP--------NLTHSMYFQQGSHFAALEMPAMLFND 452
              |.:|...         ||..: :|.|:.|        |:||......| ||||.|.|..|...
Worm   390 RYVSTPTAH---------ASGLN-ELYDRTPIEVSRHSYNITHYTEIDMG-HFAAFEAPKPLAQS 443

  Fly   453 FTAFV 457
            ...||
Worm   444 VFKFV 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh3	NP_611387.1	EHN	60..165	CDD:283978	43/106 (41%)
Jheh3	NP_611387.1	Abhydrolase	135..>251	CDD:304388	62/118 (53%)
W01A11.1	NP_504650.1	EHN	51..153	CDD:283978	43/107 (40%)
		MhpC	122..449	CDD:223669	140/356 (39%)
		Abhydrolase	126..>232	CDD:304388	57/108 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162518
Domainoid	1	1.000	223	1.000	Domainoid score	I1459
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I1529
Isobase	1	0.950	-	0	Normalized mean entropy	S2784
OMA	1	1.010	-	-		QHG63273
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	1	1.000	-	-		otm14366
orthoMCL	1	0.900	-	-		OOG6_103115
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2361
SonicParanoid	1	1.000	-	-		X2023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750