DRSC/TRiP Functional Genomics Resources

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Protein Alignment Jheh3 and Ephx2

DIOPT Version :9

Sequence 1:NP_611387.1 Gene:Jheh3 / 37182 FlyBaseID:FBgn0034406 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_031966.2 Gene:Ephx2 / 13850 MGIID:99500 Length:554 Species:Mus musculus


Alignment Length:364 Identity:74/364 - (20%)
Similarity:131/364 - (35%) Gaps:117/364 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 YKTEIQGLNIHYIHEKVSEEAKEKKHVYPLLLLHGWPGSVREFFDFIPMLTKHSNITDYAFEVVA 192
            |.|...|:.:|:: |..|..|        |.|.||:|.|...:...||.|.:      ..|.|:|
Mouse   239 YVTVKPGIRLHFV-EMGSGPA--------LCLCHGFPESWFSWRYQIPALAQ------AGFRVLA 288

  Fly   193 PSLVGYGWSDAATRPGFNAAEMATVMRNLML---RLGHKKFFIQGGDWGSIIGSNLATLYPENVI 254
            ..:.|||  |:::.|......|..:.:.::.   :||..:....|.||..::..|:|..|||.|.
Mouse   289 IDMKGYG--DSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVR 351

  Fly   255 GYHSNMCVLHT----------PLAILKGI----YGSFFPEKYLPSRFFVDHHFPVWEKWLELLEE 305
            ...|    |:|          |:.:::.|    |..:|.|..:.......:....::.:....:|
Mouse   352 AVAS----LNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDE 412

  Fly   306 SGYFHIQATKPDTIGAALTSSPVGLASYILEKFQTCTNPGLKQDFGAIVTVFGLEAVLDNLMVYY 370
            :|:  |...|...||..|.::|              .:|.|.:    |.|...:|          
Mouse   413 TGF--IAVHKATEIGGILVNTP--------------EDPNLSK----ITTEEEIE---------- 447

  Fly   371 LTNSATTAARFYLENVSKT--------YRDLQLD----------RVQSPVPMGCARFRFDLASVT 417
                      ||::...||        ||:.:.:          ::..|..|        :.:..
Mouse   448 ----------FYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALM--------VTAEK 494

  Fly   418 DWQLRDKFPNLTHSM-----YFQQG-----SHFAALEMP 446
            |..||   |.::.:|     :.::|     .|:..:|.|
Mouse   495 DIVLR---PEMSKNMEKWIPFLKRGHIEDCGHWTQIEKP 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Jheh3NP_611387.1 EHN 60..165 CDD:283978 11/36 (31%)
Abhydrolase 135..>251 CDD:304388 30/118 (25%)
Ephx2NP_031966.2 Phosphatase 1..224
HAD_sEH-N_like 3..214 CDD:319790
Phosphate binding. /evidence=ECO:0000250|UniProtKB:P34913 123..124
Epoxide hydrolase 233..554 74/364 (20%)
Abhydrolase_1 257..530 CDD:395444 67/343 (20%)
Microbody targeting signal. /evidence=ECO:0000255 552..554
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2361
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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