DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jheh3 and AgaP_AGAP008684

DIOPT Version :9

Sequence 1:	NP_611387.1	Gene:	Jheh3 / 37182	FlyBaseID:	FBgn0034406	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_314783.2	Gene:	AgaP_AGAP008684 / 1275529	VectorBaseID:	AGAP008684	Length:	458	Species:	Anopheles gambiae

Alignment Length:	460	Identity:	221/460 - (48%)
Similarity:	296/460 - (64%)	Gaps:	28/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FVGYGY---VVFTE---LTKPLPKPEFKDDTYWGPGDAKDFVPDEKIYEFKLQVPQSEIDDLRKE 75
            |||...   |||.:   ||.|:|.|:.....||||||.|.:..|..|..||:....:.|:.||.:
Mosquito     9 FVGISLATAVVFKQYRNLTAPMPVPDLNMKQYWGPGDVKQYREDTSIKPFKVSYDAAVIEKLRGK 73

  Fly    76 LNRTLRLTEPLDGIAFEYGFNTYALEQFVDYWRDNYLTKWDERQELFNSFKQYKTEIQGLNIHYI 140
            |....:||.||||:||||||||..|:..:.|||..||.||.||::..|.|..::|:|||||||||
Mosquito    74 LTDVPKLTPPLDGVAFEYGFNTNRLQDILKYWRTTYLDKWSEREKFLNKFPHFQTQIQGLNIHYI 138

  Fly   141 HEKVSEEAKEKKHVYPLLLLHGWPGSVREFFDFIPMLTKHSNITDYAFEVVAPSLVGYGWSDAAT 205
            |.|....|..|  |.|||||||||||||||:|.||:||..|...|:.|||:.|||.|||||..:.
Mosquito   139 HVKPKVPAGTK--VLPLLLLHGWPGSVREFYDIIPLLTTSSKDKDFVFEVIVPSLPGYGWSQGSA 201

  Fly   206 RPGFNAAEMATVMRNLMLRLGHKKFFIQGGDWGSIIGSNLATLYPENVIGYHSNMCVLHTPLAIL 270
            :.|.:.:|:|.||:|||.|:|.::|:||||||||:||:.:||.:..||:|.|.|||.:.|||:
Mosquito   202 KKGLSPSEVAIVMKNLMSRVGFEQFYIQGGDWGSLIGNYIATYFQSNVLGVHLNMCSIMTPLS-- 264

  Fly   271 KGIYGSFFPEKYL----PSRF----FVDHHFPVWEKWLELLEESGYFHIQATKPDTIGAALTSSP 327
                   :|:.:|    ||.|    :.|.:||:..|:..::||:||.|||:|||||||..|..:|
Mosquito   265 -------YPKMFLAALKPSLFIDEQYTDFYFPLSAKFANIIEETGYMHIQSTKPDTIGTVLQGNP 322

  Fly   328 VGLASYILEKFQTCTNPGLKQ--DFGAIVTVFGLEAVLDNLMVYYLTNSATTAARFYLENVSKTY 390
            ||||:||||||.|.|||..:.  | |.:...|.|:|:|||:|:||||:|.||:.|.|.|..:...
Mosquito   323 VGLAAYILEKFSTWTNPAYRNLAD-GGLEKYFSLDALLDNVMIYYLTDSITTSQRIYAEAFASDE 386

  Fly   391 RDLQLDRVQSPVPMGCARFRFDLASVTDWQLRDKFPNLTHSMYFQQGSHFAALEMPAMLFNDFTA 455
            ...::||:.:.||..||:||.:|....||.|:|.|.||..|.:|:.|.||||:::|.:|:.||.|
Mosquito   387 LKKEIDRIPTAVPAACAKFRHELFQQIDWVLKDHFTNLVQSNHFEDGGHFAAMQLPEVLYKDFVA 451

  Fly   456 FVGKI 460
            |:..|
Mosquito   452 FIASI 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jheh3	NP_611387.1	EHN	60..165	CDD:283978	55/104 (53%)
Jheh3	NP_611387.1	Abhydrolase	135..>251	CDD:304388	67/115 (58%)
AgaP_AGAP008684	XP_314783.2	EHN	57..161	CDD:283978	55/105 (52%)
		Abhydrolase	133..>238	CDD:304388	63/106 (59%)
		Abhydrolase_1	152..392	CDD:278959	124/249 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63273
OrthoDB	1	1.010	-	-		D260574at33208
OrthoFinder	1	1.000	-	-		FOG0002081
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21661
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2023
TreeFam	1	0.960	-	-
	8	7.890