Protein Alignment CG18190 and MAPRE1

DIOPT Version :9

• Sequence 1: NP_611384.2
• Gene: CG18190 / 37179
• FlyBaseID: FBgn0034403
• Length: 248
• Species: Drosophila melanogaster
• Sequence 2: NP_036457.1
• Gene: MAPRE1 / 22919
• HGNCID: 6890
• Length: 268
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 100/269 - (37%)
• Similarity: 146/269 - (54%)
• Gaps: 42/269 - (15%)

  Fly     4 LKLTVALTSVNAENMSRHDMLQWVNNMVHGHFKKIEELCSGAAYCQMMEMIFPNCINLKRVKMTA 68
            :.:.|..|||.::|:||||||.|:|..:..:..|||:|||||||||.|:|:||..|.||:||..|
Human     1 MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQA 65

  Fly    69 KLEHEYLHNLRLFQEAFNRLKLDKTVPIDRLIKGRFQDNFEFLQWFKKFFDSQAPGLEN------ 127
            ||||||:.|.::.|..|.|:.:||.:|:|:|:||:|||||||:||||||||:...|.:.
Human    66 KLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAAR 130

  Fly   128 -------IKSLANAPLAKPIKP---------RQFAKERSP---------------VNANDDALKE 161
                   ..||....|.||.||         |..:.:|:.               |...||...|
Human   131 QGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAE 195

  Fly   162 LIDEMKNLSLKREDIMEASNQIYNKLRLVEDLVNDMINNNQLVELCKRIQAVLYKTIDGEINEE- 225
            |:.::..|.|..||:.:..:..:.|||.:|.:..:  |..:...:.:||..:||.|.:|.:..:
Human   196 LMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQE--NEGENDPVLQRIVDILYATDEGFVIPDE 258

  Fly   226 --PVEVNED 232
              |.|..|:
Human   259 GGPQEEQEE 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18190	NP_611384.2	CH	19..>92	CDD:278723	40/72 (56%)
		EB1	184..216	CDD:281288	8/31 (26%)
MAPRE1	NP_036457.1	BIM1	16..257	CDD:227542	92/242 (38%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000269|PubMed:19543227	124..268		32/146 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..187		7/40 (18%)
		Interaction with CDK5RAP2. /evidence=ECO:0000269|PubMed:19553473	185..268		23/85 (27%)
		DCTN1-binding	208..268		16/62 (26%)
		APC-binding	220..242		5/23 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810